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Regulation of cytoplasmic dihydrotestosterone binding in dog prostate by 17 beta-estradiol.
R J Moore, … , J M Gazak, J D Wilson
R J Moore, … , J M Gazak, J D Wilson
Published March 1, 1979
Citation Information: J Clin Invest. 1979;63(3):351-357. https://doi.org/10.1172/JCI109310.
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Research Article

Regulation of cytoplasmic dihydrotestosterone binding in dog prostate by 17 beta-estradiol.

Abstract

17 beta-estradiol enchances androgen-induced prostate growth in the castrate dog to a degree comparable to that seen in spontaneous prostatic hypertrophy. To investigate the mechanism of this synergism, cytosol androgen binding was measured by a density gradient technique in prostates of control and 17 beta-estradiol-treated castrate dogs. [3H]Dihydrotestosterone was bound principally to a moiety that averaged 8.6S in size. Approximately twofold enhancement of this binding by 17 beta-estradiol was demonstrable after 1 wk of treatment with 750 microgram/wk and after 3 wk with 75 microgram/wk. Under conditions in which binding in the 8S region was demonstrable with dihydrotestosterone and testosterone no binding of 3 alpha-androstanediol or progesterone was detectable. Thus, enhancement by 17 beta-estradiol of a prostate cytosol androgen-binding protein occurs under circumstances in which 17 beta-estradiol enhances androgen-mediated prostatic growth.

Authors

R J Moore, J M Gazak, J D Wilson

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