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Research Article Free access | 10.1172/JCI109270

The cellular basis of the impaired autologous mixed lymphocyte reaction in patients with systemic lupus erythematosus.

M M Kuntz, J B Innes, and M E Weksler

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Published January 1, 1979 - More info

Published in Volume 63, Issue 1 on January 1, 1979
J Clin Invest. 1979;63(1):151–153. https://doi.org/10.1172/JCI109270.
© 1979 The American Society for Clinical Investigation
Published January 1, 1979 - Version history
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Abstract

The autologous mixed lymphocyte reaction is impaired in patients with systemic lupus erythematosus. This is because nonthymus-derived (T)-lymphocyte preparations from such patients do not stimulate autologous T-lymphocyte proliferation normally. This defect may explain the impaired generation of suppressor activity in systemic lupus erythematosus and thereby the occurrence of autoantibodies in this disease.

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