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Citations to this article

The activation of plasminogen by Hageman factor (Factor XII) and Hageman factor fragments.
G H Goldsmith Jr, … , H Saito, O S Ratnoff
G H Goldsmith Jr, … , H Saito, O S Ratnoff
Published July 1, 1978
Citation Information: J Clin Invest. 1978;62(1):54-60. https://doi.org/10.1172/JCI109113.
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The activation of plasminogen by Hageman factor (Factor XII) and Hageman factor fragments.

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Abstract

Activation of plasminogen through surface-mediated reactions is well recognized. In the presence of kaolin, purified Hageman factor (Factor XII) changed plasminogen to plasmin, as assayed upon a synthetic amide substrate and by fibrinolysis. Kinetic studies suggested an enzymatic action of Hageman factor upon its substrate, plasminogen. Hageman factor fragments, at a protein concentration equivalent to whole Hageman factor, activated plasminogen to a lesser extent. These protein preparations were not contaminated with other agents implicated in surface-mediated fibrinolysis. Diisopropyl fluorophosphate treatment of plasminogen did not inhibit its activation by Hageman factor. These studies indicate that Hageman factor has a hitherto unsuspected function, the direct activation of plasminogen.

Authors

G H Goldsmith Jr, H Saito, O S Ratnoff

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Year: 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 1985 1984 1983 1982 1981 1980 1976 Total
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