Advertisement

Research Article Free access | 10.1172/JCI109084

Alteration of the growth of cytomegalovirus and herpes simplex virus type 1 by epidermal growth factor, a contaminant of crude human chorionic gonadotropin preparations.

G E Knox, D W Reynolds, S Cohen, and C A Alford

Find articles by Knox, G. in: JCI | PubMed | Google Scholar

Find articles by Reynolds, D. in: JCI | PubMed | Google Scholar

Find articles by Cohen, S. in: JCI | PubMed | Google Scholar

Find articles by Alford, C. in: JCI | PubMed | Google Scholar

Published June 1, 1978 - More info

Published in Volume 61, Issue 6 on June 1, 1978
J Clin Invest. 1978;61(6):1635–1644. https://doi.org/10.1172/JCI109084.
© 1978 The American Society for Clinical Investigation
Published June 1, 1978 - Version history
View PDF
Abstract

Pretreatment (12-48 h) of human fibroblasts with crude, human chorionic gonadotropin (HCG) was found to suppress cytomegalovirus infection and enhance productive herpes simplex type 1 (HSV) infection in vitro. Maximal effect on virus replication occurred at the time of maximal infectivity of control cultures (48 h and 6 days after viral innoculation for HSV and cytomegalovirus, respectively). The alteration in viral growth was not due to the HCG itself, but rather to epidermal growth factor, a contaminant of crude HCG. The effect of epidermal growth factor on viral infectivity was shown to be a cell-mediated event requiring protein synthesis.

Images.

Browse pages

Click on an image below to see the page. View PDF of the complete article

Version history
  • Version 1 (June 1, 1978): No description
Advertisement
Advertisement