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Clinical Relevance of Circulating Immune Complexes in Human Leukemia: ASSOCIATION IN ACUTE LEUKEMIA OF THE PRESENCE OF IMMUNE COMPLEXES WITH UNFAVORABLE PROGNOSIS
Nicole A. Carpentier, … , Paul-Henri Lambert, Peter A. Miescher
Nicole A. Carpentier, … , Paul-Henri Lambert, Peter A. Miescher
Published October 1, 1977
Citation Information: J Clin Invest. 1977;60(4):874-884. https://doi.org/10.1172/JCI108842.
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Clinical Relevance of Circulating Immune Complexes in Human Leukemia: ASSOCIATION IN ACUTE LEUKEMIA OF THE PRESENCE OF IMMUNE COMPLEXES WITH UNFAVORABLE PROGNOSIS

Abstract

The occurrence of circulating immune complexes was investigated in 467 serum samples from 230 leukemia patients using the [125I]Clq-binding test. There was an increased serum [125I]Clq-binding activity in 40% of patients with acute myeloid leukemia, 23% with acute lymphatic leukemia, 46% in blastic crisis of chronic myeloid leukemia, 12% with chronic lymphatic leukemia, and 13% with chronic myeloid leukemia. In 48 patients, serum was also tested for soluble immune complexes by the Raji cell radioassay; the correlation between results of the two tests was significant. The Clq-binding material had properties identical with those of immune complexes. It sedimented as 14-28s material on sucrose density gradient. It contained IgG which could be dissociated at acid pH. Its Clq-binding properties could be removed after passage through anti-IgG immuno-absorbant or after a mild reduction-alkylation treatment, but were not sensitive to deoxyribonuclease treatment. Circulating immune complexes were found most commonly during the blastic stage of leukemia.

Authors

Nicole A. Carpentier, Ghislaine T. Lange, Denis M. Fiere, Gilbert J. Fournie, Paul-Henri Lambert, Peter A. Miescher

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