Circulating Immune Complexes after Renal Transplantation: CORRELATION OF INCREASED ¹²⁵I-C1_q BINDING ACTIVITY WITH ACUTE REJECTION CHARACTERIZED BY FIBRIN DEPOSITION IN THE KIDNEY

• Text
• PDF

Abstract

To assess the role of circulating immune complexes in the pathogenesis of acute rejection, sera were measured for such complexes by the 125I-C1q binding assay in 45 normal subjects, 24 allografted patients undergoing acute rejection, and in 11 allografted patients in a quiescent phase. Increased C1q-binding activity (C1q-BA) was detected in 14 patients with acute rejection, 9 of whom had renal biopsies showing fibrin deposition in the vasculature together with cellular infiltrates in the tubulo-interstitial structures; renal histology was not available in the other 5 patients. The other 10 patients with acute rejection, whose biopsies showed only cellular infiltrates, and the 11 patients in a quiescent phase posttransplantation did not have increased levels of serum C1q-BA.

Authors

Yuet M. Ooi, Boon S. Ooi, Enrique H. Vallota, Martin R. First, Victor E. Pollak