Respiratory and arterial baroreceptor reflex interactions were studied in six healthy young adults. Carotid baroreceptors were stimulated with two intensities of neck suction during early inspiration or expiration at 100 or 150% of each subject's normal tidal volume. Sinus node responses to moderate baroreflex stimuli were inhibited by inspiration, but responses to intense stimuli were not influenced by the phase of respiration. Supranormal tidal volume did not diminish responses to inspiratory baroreflex stimuli, but significantly reduced responses to expiratory stimuli. These results provide evidence for a central respiratory baroreceptor reflex interaction in man whose quality is dependent upon the level of afferent baroreceptor activity and the depth of inspiration.
D L Eckberg, C R Orshan
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Title and authors | Publication | Year |
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Inspiratory and expiratory sinus arrhythmia in healthy human
Calabrese P, Lambert\u2010Lacroix S |
Physiological Reports | 2025 |
Publication guidelines for human heart rate and heart rate variability studies in psychophysiology—Part 1: Physiological underpinnings and foundations of measurement
Quigley KS, Gianaros PJ, Norman GJ, Jennings JR, Berntson GG, de Geus EJ |
Psychophysiology | 2024 |
PIEZO ion channels: force sensors of the interoceptive nervous system
Hamed YM, Ghosh B, Marshall KL |
The Journal of physiology | 2024 |
Respiratory patterns and baroreflex function in heart failure
Radaelli A, Mancia G, Balestri G, Bonfanti D, Castiglioni P |
Scientific Reports | 2023 |
Fur seals do, but sea lions don't — cross taxa insights into exhalation during ascent from dives
SK Hooker, RD Andrews, JP Arnould, MN Bester, RW Davis, SJ Insley, NJ Gales, SD Goldsworthy, JC McKnight |
Philosophical Transactions of the Royal Society B: Biological Sciences | 2021 |
Transient effects of carotid baroreflex stimulation via the neck chamber device on central venous pressure.
Quarti-Trevano F, Seravalle G, Spaziani D, Vanoli J, Mancia G, Grassi G |
Journal of clinical hypertension (Greenwich, Conn.) | 2021 |
Cardiovagal baroreflex gain relates to sensory loss after spinal cord injury
AE Draghici, JA Taylor |
Autonomic neuroscience : basic & clinical | 2020 |
Potential Deep Brain Stimulation Targets for the Management of Refractory Hypertension
R Ems, A Garg, TA Ostergard, JP Miller |
Frontiers in neuroscience | 2019 |
Cardio-vascular reserve index (CVRI) during exercise complies with the pattern assumed by the cardiovascular reserve hypothesis
MJ Segel, BZ Bobrovsky, IE Gabbay, I Ben-Dov, R Reuveny, U Gabbay |
International Journal of Cardiology | 2017 |
Effects of inspiratory muscle training on cardiovascular autonomic control: A systematic review
RM de Abreu, P Rehder-Santos, V Minatel, GL Santos, AM Catai |
Autonomic neuroscience : basic & clinical | 2017 |
Nonlinear effects of respiration on the crosstalk between cardiovascular and cerebrovascular control systems
V Bari, A Marchi, BD Maria, G Rossato, G Nollo, L Faes, A Porta |
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences | 2016 |
Respiratory Training Improves Blood Pressure Regulation in Individuals With Chronic Spinal Cord Injury
SC Aslan, DC Randall, AV Krassioukov, A Phillips, AV Ovechkin |
Archives of Physical Medicine and Rehabilitation | 2016 |
The physiological basis and measurement of heart rate variability in humans
AE Draghici, JA Taylor |
Journal of PHYSIOLOGICAL ANTHROPOLOGY | 2016 |
Model-Derived Markers of Autonomic Cardiovascular Dysfunction in Sleep-Disordered Breathing
MC Khoo, P Chalacheva |
Sleep Medicine Clinics | 2016 |
The effect of α 1 -adrenergic blockade on post-exercise brachial artery flow-mediated dilatation at sea level and high altitude: Post-exercise endothelial function at sea level and high altitude
MM Tymko, JC Tremblay, AB Hansen, CA Howe, CK Willie, M Stembridge, DJ Green, RL Hoiland, P Subedi, JD Anholm, PN Ainslie |
The Journal of Physiology | 2016 |
Carotid baroreflex function at the onset of cycling in men
TC Barbosa, LC Vianna, T Hashimoto, LG Petersen, ND Olesen, H Tsukamoto, H Sørensen, S Ogoh, AC Nóbrega, NH Secher |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2016 |
From a cardio-vascular reserve hypothesis to a proposed measurable index: A pilot empirical validation
U Gabbay, BZ Bobrovsky, I Ben-Dov, R Durst, IE Gabbay, MJ Segel |
Clinical Trials and Regulatory Science in Cardiology | 2015 |
Comprehensive Physiology
SN Cheuvront, RW Kenefick |
Comprehensive Physiology | 2014 |
Acute effects of autoadjusting and fixed continuous positive airway pressure treatments on cardiorespiratory coupling in obese patients with obstructive sleep apnea
V Patruno, E Tobaldini, AM Bianchi, MO Mendez, O Coletti, G Costantino, N Montano |
European Journal of Internal Medicine | 2014 |
Central regulation of heart rate and the appearance of respiratory sinus arrhythmia: New insights from mathematical modeling
A Ben-Tal, SS Shamailov, JF Paton |
Mathematical Biosciences | 2014 |
Conditional symbolic analysis detects nonlinear influences of respiration on cardiovascular control in humans
A Porta, A Marchi, V Bari, K Heusser, J Tank, J Jordan, F Barbic, R Furlan |
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences | 2014 |
The interplay between sympathetic overactivity, hypertension and heart rate variability (Review, invited)
I Harsanji-Drenjancevic, I Grizelj, I Harsanji-Drenjancevic, A Cavka, K Selthofer-Relatic |
Acta Physiologica Hungarica | 2014 |
Drawing breath without the command of effectors: The control of respiration following spinal cord injury
PM Warren, BI Awad, WJ Alilain |
Respiratory Physiology & Neurobiology | 2014 |
The effect of sets and repetitions of the spirometer by flow in cardiorespiratory parameters
B Martinelli, GD Souza, MD Ricci, C Gimenes, MH de Conti, SR Barrile |
Fisioterapia em Movimento | 2014 |
Reprint of “Drawing breath without the command of effectors: The control of respiration following spinal cord injury”
PM Warren, BI Awad, WJ Alilain |
Respiratory Physiology & Neurobiology | 2014 |
Human baroreflex rhythms persist during handgrip and muscle ischaemia
DL Eckberg, WH Cooke, A Diedrich, BD Levine, JA Pawelczyk, JC Buckey, AC Ertl, I Biaggioni, JF Cox, D Robertson, FJ Baisch, CG Blomqvist, TA Kuusela, KU Tahvanainen |
Acta Physiologica | 2013 |
Effects of acute and long-term slow breathing exercise on muscle sympathetic nerve activity in untreated male patients with hypertension:
D Hering, W Kucharska, T Kara, VK Somers, G Parati, K Narkiewicz |
Journal of Hypertension | 2013 |
Time-frequency methods and voluntary ramped-frequency breathing: a powerful combination for exploration of human neurophysiological mechanisms
T Stankovski, WH Cooke, L Rudas, A Stefanovska, DL Eckberg |
Journal of applied physiology | 2013 |
CASE REPORTS OF TRANSIENT AUTONOMIC DYSFUNCTION IN COPD PATIENTS UNDERGOING MAJOR SURGERIES
P S, N S, K Sridharan |
2013 | |
Baroreflex Function after Spinal Cord Injury
AA Phillips, AV Krassioukov, PN Ainslie, DE Warburton |
Journal of Neurotrauma | 2012 |
Forebrain organization representing baroreceptor gating of somatosensory afferents within the cortical autonomic network
R Goswami, MF Frances, CD Steinback, JK Shoemaker |
Journal of neurophysiology | 2012 |
Can baroreflex measurements with spontaneous sequence analysis be improved by also measuring breathing and by standardization of filtering strategies?
MR Hollow, TH Clutton-Brock, MJ Parkes |
Physiological Measurement | 2011 |
Postnatal development of baroreflex sensitivity in infancy
SR Yiallourou, SA Sands, AM Walker, RS Horne |
The Journal of Physiology | 2010 |
Respiratory Modulation Of Premotor Cardiac Vagal Neurons In The Brainstem
O Dergacheva, KJ Griffioen, RA Neff, D Mendelowitz |
Respiratory Physiology & Neurobiology | 2010 |
Autonomic dysfunction in patients with chronic obstructive pulmonary disease (COPD)
A Gestel, J Steier |
Journal of Thoracic Disease | 2010 |
Carotid baroreflex testing using the neck collar device
VL Cooper, R Hainsworth |
Clinical Autonomic Research | 2009 |
Respiratory modulation of cardiovagal baroreflex sensitivity
YC Tzeng, PY Sin, SJ Lucas, PN Ainslie |
Journal of applied physiology | 2009 |
Point:Counterpoint: Respiratory sinus arrhythmia is due to a central mechanism vs. respiratory sinus arrhythmia is due to the baroreflex mechanism
DL Eckberg |
Journal of applied physiology | 2009 |
Baroreflex Sensitivity: Measurement and Clinical Implications
MT la Rovere, GD Pinna, G Raczak |
Annals of Noninvasive Electrocardiology | 2008 |
Atrial Fibrillation
A Natale, J Jalife |
2008 | |
Baroreflex Sensitivity: Measurement and Clinical Implications
MT Rovere, GD Pinna, G Raczak |
Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc | 2008 |
A Nonlinear Model of Cardiac Autonomic Control in Obstructive Sleep Apnea Syndrome
JA Jo, A Blasi, EM Valladares, R Juarez, A Baydur, MC Khoo |
Annals of Biomedical Engineering | 2007 |
Antihypertensive Drugs and the Sympathetic Nervous System
SD Colle, F Morello, F Rabbia, A Milan, D Naso, E Puglisi, P Mulatero, F Veglio |
Journal of Cardiovascular Pharmacology | 2007 |
Exercise intensity influences cardiac baroreflex function at the onset of isometric exercise in humans
JP Fisher, S Ogoh, CN Young, DM Keller, PJ Fadel |
Journal of applied physiology | 2007 |
Modulations of human autonomic function induced by positive pressure-assisted breathing
M Garet, JC Barthelemy, F Degache, V Pichot, D Duverney, F Roche |
Clinical Physiology and Functional Imaging | 2006 |
Effects of slow, controlled breathing on baroreceptor control of heart rate and blood pressure in healthy men
A Radaelli, R Raco, P Perfetti, A Viola, A Azzellino, MG Signorini, AU Ferrari |
Journal of Hypertension | 2004 |
Contribution of the respiratory rhythm to sinus arrhythmia in normal unanesthetized subjects during positive-pressure mechanical hyperventilation
HE Cooper, TH Clutton-Brock, MJ Parkes |
American journal of physiology. Heart and circulatory physiology | 2004 |
Individual differences in respiratory sinus arrhythmia
SB Lamine, P Calabrese, H Perrault, TP Dinh, A Eberhard, G Benchetrit |
American journal of physiology. Heart and circulatory physiology | 2004 |
Respiratory sinus arrhythmia in freely moving and anesthetized rats
E Bouairi, R Neff, C Evans, A Gold, MC Andresen, D Mendelowitz |
Journal of applied physiology | 2004 |
Stress reduction and blood pressure control in hypertension: a role for transcendental meditation?
G Parati, A Steptoe |
Journal of Hypertension | 2004 |
Neural Mechanisms of Cardiovascular Regulation
NJ Dun, BH Machado, PM Pilowsky |
2004 | |
Modulation of baroreflex function by altering inspiratory impedance: Potential mechanisms and clinical implications
MW Chapleau |
Clinical Autonomic Research | 2004 |
Relationship between breath-synchronous arterial pressure and heart rate variations during orthostatic stress
P Sundblad, D Linnarsson |
Clinical Physiology and Functional Imaging | 2003 |
Topical Review. The human respiratory gate
DL Eckberg |
The Journal of Physiology | 2003 |
The human respiratory gate
DL Eckberg |
The Journal of Physiology | 2003 |
Carotid baroreflex function during and following voluntary apnea in humans
NM Swift, MJ Cutler, PJ Fadel, WL Wasmund, S Ogoh, DM Keller, PB Raven, ML Smith |
American journal of physiology. Heart and circulatory physiology | 2003 |
Directionality of coupling of physiological subsystems: age-related changes of cardiorespiratory interaction during different sleep stages in babies
R Mrowka, L Cimponeriu, A Patzak, MG Rosenblum |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2003 |
CO 2 -dependent components of sinus arrhythmia from the start of breath holding in humans
HE Cooper, MJ Parkes, TH Clutton-Brock |
American journal of physiology. Heart and circulatory physiology | 2003 |
Arterial baroreflex function and cardiovascular variability: interactions and implications
PA Lanfranchi, VK Somers |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2002 |
Influence of respiratory motor neurone activity on human autonomic and haemodynamic rhythms
AS Gonschorek, LL Lu, JR Halliwill, LA Beightol, JA Taylor, JA Painter, H Warzel, DL Eckberg |
Clinical Physiology | 2001 |
Effects of noradrenaline on human vagal baroreflexes
KE Airaksinen, HV Huikuri, L Hubti, TA Kuusela, KU Tahvanainen, M Tulppo, T Mäkikallio, DL Eckberg |
Annals of Medicine | 2001 |
Physiological basis for human autonomic rhythms
DL Eckberg |
Annals of Medicine | 2000 |
Cardiorespiratory interactions during resistive load breathing
P Calabrese, H Perrault, TP Dinh, A Eberhard, G Benchetrit |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2000 |
Human responses to upright tilt: a window on central autonomic integration
WH Cooke, JB Hoag, AA Crossman, TA Kuusela, KU Tahvanainen, DL Eckberg |
The Journal of Physiology | 1999 |
Baroreflex and non-baroreflex modulation of vagal cardiac control after myocardial infarction
G Grassi, G Seravalle, C Giannattasio, A Saino, C Turri, G Mancia |
The American Journal of Cardiology | 1999 |
Neuromonitoring
M Stöhr, W Wagner, K Pfadenhauer, K Scheglmann |
1999 | |
Chemo- and baroresponses differ in African-Americans and Caucasians in sleep
I Crisostomo, A Zayyad, DW Carley, J Abubaker, E Önal, EJ Stepanski, M Lopata, RC Basner |
Journal of applied physiology | 1998 |
Heart rate variability: Origins, methods, and interpretive caveats
GG Berntson, JT Bigger, DL Eckberg, P Grossman, PG Kaufmann, M Malik, HN Nagaraja, SW Porges, JP Saul, PH Stone, MW der Molen |
Psychophysiology | 1997 |
Modelling the Dynamics of Biological Systems
E Mosekilde, OG Mouritsen |
1995 | |
Respiratory modulation in the activity of sympathetic neurones
HJ Häbler, W Jänig, M Michaelis |
Progress in Neurobiology | 1994 |
Testing arterial baroreflex function in acutely unwell patients
ID Anderson, RA Little |
Clinical Physiology | 1992 |
Frequency-Specific Amplification of Heart Rate Rhythms Using Oscillatory Tilt
EA Byrne, SW Porges |
Psychophysiology | 1992 |
Temporal Variations of the Cardiovascular System
TF Schmidt, BT Engel, G Blümchen |
1992 | |
Use of the photoplethysmographic technique to analyze the valsalva maneuver in normal man
EE Benarroch, TL Opfer-Gehrking, PA Low |
Muscle & Nerve | 1991 |
Baroreceptor Reflexes
PB Persson, HR Kirchheim |
1991 | |
Cardiorespiratory and Motor Coordination
HP Koepchen, T Huopaniemi |
1991 | |
Advances in Ergometry
N Bachl, TE Graham, H Löllgen |
1991 | |
Blood Pressure Measurements
W Meyer-Sabellek, R Gotzen, M Anlauf, L Steinfeld |
1990 | |
Etude de l'activité baroréflexe lors de l'endartériectomie carotidienne sous anesthésie générale
G Godet, JM Bernard, M Bertrand, S Mouren, E Kieffer, P Viars |
Annales Françaises d’Anesthésie et de Réanimation | 1989 |
High frequency jet ventilation (HFJV) has no better haemodynamic tolerance than controlled mechanical ventilation (CMV) in cardiogenic shock
G Crimi, G Conti, M Bufi, M Antonelli, RA Blasi, C Mattia, R Romano, A Gasparetto |
Intensive Care Medicine | 1988 |
Baroreflex modulation of sympathetic activity and sympathetic neurotransmitters in humans
DL Eckberg, RF Rea, OK Andersson, T Hedner, J Pernow, JM Lundberg, BG Wallin |
Acta Physiologica Scandinavica | 1988 |
Indirekte 24-Stunden Blutdruckmessung
W Meyer-Sabellek, R Gotzen |
1988 | |
High frequency jet ventilation (HFJV) has no better haemodynamic tolerance than controlled mechanical ventilation (CMV) in cardiogenic shock
G Crimi, G Conti, M Bufi, M Antonelli, RA de Blasi, C Mattia, R Romano, A Gasparetto |
Intensive Care Medicine | 1988 |
Temporal Disorder in Human Oscillatory Systems
L Rensing, U an der Heiden, MC Mackey |
1987 | |
Effect of posture on arterial baroreflex control of heart rate in humans
MH Harrison, D Rittenhouse, JE Greenleaf |
European Journal of Applied Physiology and Occupational Physiology | 1986 |
Cardiorespiratory and Cardiosomatic Psychophysiology
P Grossman, KH Janssen, D Vaitl |
1986 | |
Respiratory modulation of muscle sympathetic and vagal cardiac outflow in man
DL Eckberg, C Nerhed, BG Wallin |
The Journal of Physiology | 1985 |
Respiration, Stress, and Cardiovascular Function
P Grossman |
Psychophysiology | 1983 |
Muscarinic cholinergic receptors modulate vagal cardiac responses in man
M Raczkowska, DL Eckberg, TJ Ebert |
Journal of the Autonomic Nervous System | 1983 |
Heart rate and breathing pattern: Interactions and sex differences
P Sbert |
European Journal of Applied Physiology and Occupational Physiology | 1983 |
Control of Respiration
DJ Pallot |
1983 | |
The Cardiac Cycle Time Effect: Influence of Respiration Phase and Information Processing Requirements
MG Coles, AM Pellegrini, GV Wilson |
Psychophysiology | 1982 |
Autonome Innervation des Herzens
B Brisse, F Bender |
1982 | |
Excitation and inhibition of cardiac vagal motoneurones by electrical stimulation of the carotid sinus nerve
DI McCloskey, EK Potter |
The Journal of Physiology | 1981 |
Cardiovascular Physiology Neural Control Mechanisms
RJ Traystman, GH Gurtner, MC Rogers, MD Jones, RC Koehler |
Cardiovascular Physiology Neural Control Mechanisms | 1981 |
Carotid baroreflex heart rate control during the active and the assisted breathing cycle in man
A Melcher |
Acta Physiologica Scandinavica | 1980 |
Phase relationship between normal human respiration and baroreflex responsiveness
DL Eckberg, YT Kifle, VL Roberts |
The Journal of Physiology | 1980 |
Nonlinearities of the human carotid baroreceptor-cardiac reflex
DL Eckberg |
Circulation research | 1980 |
Arterial pressure and pulse interval responses to repetitive carotid baroreceptor stimuli in man
AL Baskerville, DL Eckberg, MA Thompson |
The Journal of Physiology | 1979 |