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Citations to this article

Characterization of the inappropriate gonadotropin secretion in polycystic ovary syndrome.
R Rebar, … , G Vandenberg, F Naftolin
R Rebar, … , G Vandenberg, F Naftolin
Published May 1, 1976
Citation Information: J Clin Invest. 1976;57(5):1320-1329. https://doi.org/10.1172/JCI108400.
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Characterization of the inappropriate gonadotropin secretion in polycystic ovary syndrome.

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Abstract

To evaluate gonadotropin release in polycystic ovary syndrome (PCO), one or more of the following hypothalamic-pituitary function tests were performed on 24 patients with the syndrome. These tests included (a) the pulsatile pattern and day-to-day fluctuation of gonadotropin release; (b) effects of exogenous estrogen and antiestrogen (clomiphene) administration on gonadotropin release; and (c) pituitary responsiveness to maximal (150 mug) and submaximal (10 mug) luteinizing hormone-releasing factor (LRF) injections. In 10 of the 14 patients sampled frequently (15 min) for 6 h, luteinizing hormone (LH) levels were elevated above the concentration seen in normal cycling women (except the LH surge). These high LH concentrations appeared to be maintained by and temporally related to the presence of exaggerated pulsatile LH release, either in the form of enhanced amplitude or increased frequency. In all subjects, levels of follicle-stimulating hormone (FSH) were low or low normal, and a pulsatile pattern was not discernible. In four patients, daily sampling revealed marked day-to-day fluctuation of LH but not FSH. That the elevated LH levels were not related to a defect in the negative-feedback effect of estrogen was suggested by the appropriate fall of LH in four patients given an acute intravenous infusion of 17beta-estradiol. This infusion had no effect on FSH levels. In addition, clomiphene elicited rises of both LH and FSH that were comparable to the ones observed in normal women given the same treatment. The clomiphene study also suggested that the positive-feed-back mechanism of estrogen on LH release was intact when the preovulatory rises of 17beta-estradiol induced appropriate LH surges. The elevated LH levels appeared to be related to a heightened pituitary responsiveness to the LRF. This was found in the 11 and 2 patients given maximal (150 mug) and submaximal (10 mug) doses of LRF, respectively. The augmented pituitary sensitivity for LH release correlated with the basal levels of both estrone (P less than 0.025) and 17beta-estradiol (P less than 0.02). The net increase in FSH was significantly greater (P less than 0.001) in the PCO patients than the normal women with maximal doses of LRF. With the smaller dose study none of the injections had a discernible effect on FSH concentrations in either subject. The disparity between LH and FSH secretion could be explained by the preferential inhibitory action of estrogen on FSH release, coupled with a relative insensitivity of FSH release. These data indicate that in these PCO patients the abnormalities of the hypothalamic-pituitary regulation of gonadotropin secretion was not an inherent defect but represented a functional derangement consequent to inappropriate estrogen feedback, which led to a vicious cycle of chronic anovulation and inappropriate gonadotropin secretion.

Authors

R Rebar, H L Judd, S S Yen, J Rakoff, G Vandenberg, F Naftolin

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Seminars in reproductive medicine 2011
Reproductive Hormone Levels and Anthropometry in Postmenopausal Women with Polycystic Ovary Syndrome (PCOS): A 21-Year Follow-Up Study of Women Diagnosed with PCOS around 50 Years Ago and Their Age-Matched Controls
J Schmidt, M Brännström, K Landin-Wilhelmsen, E Dahlgren
The Journal of clinical endocrinology and metabolism 2011
Prenatal Androgenization of Female Mice Programs an Increase in Firing Activity of Gonadotropin-Releasing Hormone (GnRH) Neurons That Is Reversed by Metformin Treatment in Adulthood
AV Roland, SM Moenter
Endocrinology 2010
Use of metformin in the treatment of polycystic ovary syndrome
AD Genazzani, F Ricchieri, C Lanzoni
Women's Health 2010
Rescue of Obesity-Induced Infertility in Female Mice due to a Pituitary-Specific Knockout of the Insulin Receptor (IR)
KJ Brothers, S Wu, SA DiVall, MR Messmer, CR Kahn, RS Miller, S Radovick, FE Wondisford, A Wolfe
Cell Metabolism 2010
Ginecología endocrina: métodos de determinación, exploración dinámica y molecular
S Trabado, J Bouligand, A Guiochon-Mantel, S Brailly-Tabard
EMC - Ginecología-Obstetricia 2010
Gynécologie endocrinienne : méthodes de dosage, exploration dynamique et moléculaire
S Trabado, J Bouligand, A Guiochon-Mantel, S Brailly-Tabard
EMC - Gynécologie 2010
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
Yen & Jaffe's Reproductive Endocrinology
RA Lobo
Yen & Jaffe's Reproductive Endocrinology 2009
Reproducibility of luteinizing hormone hypersecretion in different phases of the menstrual cycle in polycystic ovary syndrome
T Iwasa, T Matsuzaki, M Murakami, F Shimizu, A Kuwahara, T Yasui, M Irahara
Journal of Obstetrics and Gynaecology Research 2009
Yen & Jaffe's Reproductive Endocrinology
SF Thung, ER Norwitz
Yen & Jaffe's Reproductive Endocrinology 2009
Low-frequency electroacupuncture and physical exercise decrease high muscle sympathetic nerve activity in polycystic ovary syndrome
E Stener-Victorin, E Jedel, PO Janson, YB Sverrisdottir
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2009
Acute Effects of Testosterone Infusion on the Serum Luteinizing Hormone Profile in Eumenorrheic and Polycystic Ovary Syndrome Adolescents
MG Ropelato, MC Rudaz, ME Escobar, SV Bengolea, ML Calcagno, JD Veldhuis, M Barontini
The Journal of clinical endocrinology and metabolism 2009
Novartis Foundation Symposia
EJ Campbell
Ciba Foundation Symposium 44 - Research and Medical Practice: Their Interaction 2008
Insulin resistance and polycystic ovary syndrome
A Galluzzo, MC Amato, C Giordano
Nutrition, Metabolism and Cardiovascular Diseases 2008
The evaluation of metabolic parameters and insulin sensitivity for a more robust diagnosis of the polycystic ovary syndrome
MC Amato, A Galluzzo, S Finocchiaro, A Criscimanna, C Giordano
Clinical Endocrinology 2008
The Effects of Clomiphene Citrate Administration in Ovariectomised Rats: An Ultrastructural Study
BG ., MA ., YN ., CI ., MA ., SK .
Journal of Biological Sciences 2008
Neuroendocrine dysfunction in PCOS: a critique of recent reviews
SA Doi
Clinical medicine & research 2008
Ménométrorragies : à qui, pourquoi, sur quels critères proposer une exploration hormonale ?
S Brailly-Tabard, S Trabado, O Khallouf
Journal de Gynécologie Obstétrique et Biologie de la Reproduction 2008
Developmental Programming: Impact of Prenatal Testosterone Excess on Pre- and Postnatal Gonadotropin Regulation in Sheep1
M Manikkam, RC Thompson, C Herkimer, KB Welch, J Flak, FJ Karsch, V Padmanabhan
Biology of reproduction 2008
Evidence for Insulin Suppression of Baseline Luteinizing Hormone in Women with Polycystic Ovarian Syndrome and Normal Women
MA Lawson, S Jain, S Sun, K Patel, PJ Malcolm, RJ Chang
The Journal of clinical endocrinology and metabolism 2008
Hyperandrogenism and Hyperinsulinism in Children of Women with Polycystic Ovary Syndrome: A Controlled Study
SC Kent, CL Gnatuk, AR Kunselman, LM Demers, PA Lee, RS Legro
The Journal of clinical endocrinology and metabolism 2008
Women’s Health in Clinical Practice
AL Clouse, K Sherif
2008
Polycystic ovary syndrome
RJ Norman, D Dewailly, RS Legro, TE Hickey
The Lancet 2007
Lack of effect of short-term diazoxide administration on luteinizing hormone secretion in women with polycystic ovary syndrome
WS Evans, AE Taylor, DG Boyd, ML Johnson, DW Matt, Y Jimenez, JE Nestler
Fertility and Sterility 2007
The reproductive phenotype in polycystic ovary syndrome
RJ Chang
Nature Clinical Practice Endocrinology & Metabolism 2007
Diagnosis of Polycystic Ovary Syndrome
B Trivax, R Azziz
Clinical Obstetrics and Gynecology 2007
Polycystic Ovary Syndrome
MA Brown, RJ Chang
Ultrasound Quarterly 2007
Clomiphene, Metformin, or Both for Infertility in the Polycystic Ovary Syndrome
RS Legro, HX Barnhart, WD Schlaff, BR Carr, MP Diamond, SA Carson, MP Steinkampf, C Coutifaris, PG McGovern, NA Cataldo, GG Gosman, JE Nestler, LC Giudice, PC Leppert, ER Myers
New England Journal of Medicine 2007
The ESHRE/ASRM consensus on polycystic ovary syndrome (PCOS) – an extended critical analysis
F Geisthövel, T Rabe
Reproductive BioMedicine Online 2007
Luteinizing hormone pulsatility in patients with major ovarian hyperandrogenism
A Bachelot, K Laborde, JL Bresson, G Plu-Bureau, A Raynaud, X Bertagna, A Mogenet, M Mansour, V Lucas-Jouy, JP Gayno, Y Reznik, JM Kuhn, L Billaud, MC Vacher-Lavenu, M Putterman, I Mowszowicz, P Touraine, F Kuttenn
Journal of Endocrinological Investigation 2007
Pharmacokinetic Factors Contribute to the Inverse Relationship between Luteinizing Hormone and Body Mass Index in Polycystic Ovarian Syndrome
SS Srouji, YL Pagán, F DAmato, A Dabela, Y Jimenez, JG Supko, JE Hall
The Journal of clinical endocrinology and metabolism 2007
Androgen Excess Disorders in Women
R Azziz, JE Nestler, D Dewailly
2007
When Puberty is Precocious
OH Pescovitz, EC Walvoord
2007
Diagnosis, epidemiology, and genetics of the polycystic ovary syndrome
MO Goodarzi, R Azziz
Best Practice & Research Clinical Endocrinology & Metabolism 2006
Pituitary?ovarian response to the gonadotrophin-releasing hormone-agonist test in anovulatory patients with polycystic ovary syndrome: predictive role of ovarian stroma
AM Fulghesu, S Angioni, C Belosi, R Apa, L Selvaggi, M Ciampelli, A Iuculano, GB Melis, A Lanzone
Clinical Endocrinology 2006
Polycystic Ovarian Syndrome
KA Khan, S Stas, LR Kurukulasuriya
Journal of the CardioMetabolic Syndrome 2006
Effects of metformin on inappropriate LH release in women with polycystic ovarian syndrome and insulin resistance
A Ulloa-Aguirre, L Portocarrero, T Zariñán, A Olivares, S Carranza-Lira, JD Veldhuis, JC López-Alvarenga
Reproductive BioMedicine Online 2006
Entre el hirsutismo y el síndrome del ovario poliquístico: análisis desde una perspectiva histórica
F Escobar-Jiménez, MM Campos, ML Díaz
Endocrinología y Nutrición 2006
The origins and sequelae of abnormal neuroendocrine function in polycystic ovary syndrome
SK Blank, CR McCartney, JC Marshall
Human Reproduction Update 2006
Effects of Simvastatin and Oral Contraceptive Agent on Polycystic Ovary Syndrome: Prospective, Randomized, Crossover Trial
B Banaszewska, L Pawelczyk, RZ Spaczynski, J Dziura, AJ Duleba
The Journal of clinical endocrinology and metabolism 2006
Inverse Relationship between Luteinizing Hormone and Body Mass Index in Polycystic Ovarian Syndrome: Investigation of Hypothalamic and Pituitary Contributions
YL Pagán, SS Srouji, Y Jimenez, A Emerson, S Gill, JE Hall
The Journal of clinical endocrinology and metabolism 2006
Insulin Resistance in Polycystic Ovarian Disease
V Bhatia
Southern Medical Journal 2005
Ovarian steroids modulate neuroendocrine dysfunction in polycystic ovary syndrome
SA Doi, M Al-Zaid, PA Towers, CJ Scott, KA Al-Shoumer
Journal of Endocrinological Investigation 2005
Skin temperature rise induced by calcitonin gene-related peptide in gonadotropin-releasing hormone analogue-treated female rats and alleviation by Keishi-bukuryo-gan, a Japanese herbal medicine
M Noguchi, Y Ikarashi, M Yuzurihara, Y Kase, K Watanabe, GA Plotnikoff, S Takeda, M Aburada
Life Sciences 2005
Effects of experimental hyperandrogenemia on the female rat reproductive axis: Suppression of progesterone-receptor messenger RNA expression in the brain and blockade of luteinizing hormone surges
EM Foecking, JE Levine
Gender Medicine 2005
Endocrine–metabolic effects of the treatment with pioglitazonein obese patients with polycystic ovary syndrome
HM Garmes, MA Tambascia, DE Zantut-Wittmann
Gynecological Endocrinology 2005
Androgen excess fetal programming of female reproduction: a developmental aetiology for polycystic ovary syndrome?
DH Abbott, DK Barnett, CM Bruns, DA Dumesic
Human Reproduction Update 2005
Spironolactone for Hirsutism in Polycystic Ovary Syndrome
NA Christy, AS Franks, LB Cross
The Annals of pharmacotherapy 2005
Relationship of GnRH-stimulated LH release to episodic LH secretion and baseline endocrine-metabolic measures in women with polycystic ovary syndrome
K Patel, MS Coffler, MH Dahan, PJ Malcom, R Deutsch, RJ Chang
Clinical Endocrinology 2004
Polycystic ovarian syndrome: diagnosis and management
MT Sheehan
Clinical medicine & research 2004
PCOS: a diagnostic challenge
R Azziz
Reproductive BioMedicine Online 2004
Nonhuman Primates Contribute Unique Understanding to Anovulatory Infertility in Women
DH Abbott, SC Foong, DK Bernett, DA Dumesic
ILAR journal / National Research Council, Institute of Laboratory Animal Resources 2004
The pathophysiology of polycystic ovary syndrome: trying to understand PCOS and its endocrinology
A Balen
Best Practice & Research Clinical Obstetrics & Gynaecology 2004
The pathogenesis of infertility and early pregnancy loss in polycystic ovary syndrome
ZM van der Spuy, SJ Dyer
Best Practice & Research Clinical Obstetrics & Gynaecology 2004
Reduction of dehydroepiandrosterone sulfate synthesis in women with polycystic ovary syndrome by human menopausal gonadotropin but not purified urinary follicle stimulating hormone: a comparative pilot study
S Turkmen, T Backstrom, M Idil
Gynecological Endocrinology 2004
A comment on the European Society of Human Reproduction and Embryology/American Society for Reproductive Medicine consensus of the polycystic ovarian syndrome
F Geisthövel
Reproductive BioMedicine Online 2003
The Ovary
BC Vanderhyden, TJ Shaw, K Garson, AM Tonary
The Ovary 2003
The Effect of Herbal Medicine on Nerve Growth Factor in Estradiol Valerate-induced Polycystic Ovaries in Rats
JC Lee, SC Pak, SH Lee, SC Lim, YH Bai, CS Jin, JS Kim, CS Na, CS Bae, KS Oh, BC Choi
The American journal of Chinese medicine 2003
Metformin for the Treatment of Polycystic Ovary Syndrome:
RL Barbieri
Obstetrics & Gynecology 2003
Endocrine and Metabolic Responses to Long-Term Monotherapy with the Antiepileptic Drug Valproate in the Normally Cycling Rhesus Monkey
M Ferin, M Morrell, E Xiao, L Kochan, F Qian, T Wright, M Sauer
The Journal of clinical endocrinology and metabolism 2003
Increased Luteinizing Hormone Secretion in Women with Polycystic Ovary Syndrome Is Unaltered by Prolonged Insulin Infusion
K Patel, MS Coffler, MH Dahan, RY Yoo, MA Lawson, PJ Malcom, RJ Chang
The Journal of clinical endocrinology and metabolism 2003
Gonadotropin secretory dynamics in polycystic ovary syndrome
EM Baker, SA Flora, JE Ferguson, WS Evans
Current Opinion in Endocrinology & Diabetes 2002
Polycystic ovary syndrome [PCOS]: Comprehensive management in primary care
GP Samraj, L Kuritzky
Comprehensive Therapy 2002
Insulin Resistance in the Sisters of Women with Polycystic Ovary Syndrome: Association with Hyperandrogenemia Rather Than Menstrual Irregularity
RS Legro, R Bentley-Lewis, D Driscoll, SC Wang, A Dunaif
The Journal of clinical endocrinology and metabolism 2002
Metformin and Polycystic Ovary Syndrome: A Literature Review
KA Awartani, AP Cheung
Journal of Obstetrics and Gynaecology Canada 2002
Chronic Nitric Oxide Deficiency is Associated with Altered Leutinizing Hormone and Follicle-Stimulating Hormone Release in Ovariectomized Rats 1
MJ Barnes, K Lapanowski, JA Rafols, DM Lawson, JC Dunbar
Experimental biology and medicine (Maywood, N.J.) 2002
Relationships between circulating leptin concentrations and other hormonal parameters in obese and non-obese women with polycystic ovary syndrome: Leptin concentration in women with PCOS
N Kikuchi, K Andoh, H Mizunuma, T Minegishi
Reproductive Medicine and Biology 2002
Advances in the treatment of polycystic ovary syndrome
P Moghetti
Expert Opinion on Investigational Drugs 2001
Definition and causes of infertility
S Brugo-Olmedo, C Chillik, S Kopelman
Reproductive BioMedicine Online 2001
Mechanisms of Hypothalamic-Pituitary-Gonadal Disruption in Polycystic Ovarian Syndrome
M Barontini, MC Garcı́a-Rudaz, JD Veldhuis
Archives of Medical Research 2001
Polycystic Ovary Syndrome And Hyperprolactinemia
N Bracero, HA Zacur
Obstetrics and Gynecology Clinics of North America 2001
Neuromodulation in Polycystic Ovary Syndrome
BN Kalro, TL Loucks, SL Berga
Obstetrics and Gynecology Clinics of North America 2001
Síndrome de ovarios poliquísticos: hiperinsulinemia relacionada con riesgo cardiovascular
LC Tejerizo-López, A Tejerizo-García, MM Sánchez-Sánchez, RM García-Robles, A Leiva, E Morán, F Corredera, JA Pérez-Escanilla, JM Benavente
Clínica e Investigación en Ginecología y Obstetricia 2001
Effects of androstenedione, insulin and luteinizing hormone on steroidogenesis in human granulosa luteal cells
S Greisen, T Ledet, P Ovesen
Human Reproduction 2001
The use of a combined regimen of GnRH agonist plus a low-dose oral contraceptive improves the spontaneous pulsatile LH secretory characteristics in patients with polycycstic ovary disease after discontinuation of treatment
AD Genazzani, C Battaglia, O Gamba, F Petraglia, B Malavasi, AR Genazzani
Journal of Assisted Reproduction and Genetics 2000
O sistema renina-angiotensina em ovário
AP Raposo-Costa, AM Reis
Arquivos brasileiros de endocrinologia e metabologia 2000
The Importance of Diagnosing the Polycystic Ovary Syndrome
RA Lobo, E Carmina
Annals of internal medicine 2000
Normal Ovulatory Women with Polycystic Ovaries Have Hyperandrogenic Pituitary-Ovarian Responses To Gonadotropin-Releasing Hormone-Agonist Testing*
PL Chang, SR Lindheim, C Lowre, M Ferin, F Gonzalez, L Berglund, E Carmina, MV Sauer, RA Lobo
The Journal of clinical endocrinology and metabolism 2000
NEUROENDOCRINE ASPECTS OF POLYCYSTIC OVARY SYNDROME
JC Marshall, CA Eagleson
Endocrinology & Metabolism Clinics of North America 1999
Analysis of gonadotropin pulsatility in hirsute women with normal menstrual cycles and in women with polycystic ovary syndrome
SL Minanni, JA Marcondes, BL Wajchenberg, AM Cavaleiro, MA Fortes, MA Rego, DP Vezozzo, D Robard, D Giannella-Neto
Fertility and Sterility 1999
Polcystic ovary syndrome and implications for the menopause
RJ Norman, E McVeigh
Climacteric 1999
POLYCYSTIC OVARY SYNDROME
RS Legro
Endocrinology & Metabolism Clinics of North America 1999
Effects of the insulin sensitizing drug metformin on ovarian function, follicular growth and ovulation rate in obese women with oligomenorrhoea
IR Pirwany, RW Yates, IT Cameron, R Fleming
Human Reproduction 1999
Clinical, Hormonal, and Radiological Studies at Baseline, During and After Long Term GnRH Analog (Leuprolide) Treatment in Adolescent Hirsute Females with Increased Ovarian Androgen Production Due to Polycystic Ovary Syndrome
YT Chang, MJ Suriano, L Garibaldi, L Riddick, S Pang
Clinical Pediatric Endocrinology 1999
Increased Bioactive Luteinizing Hormone Levels and Bio/Immuno Ratio in Women with Hyperthecosis of the Ovaries: Possible Role of Hyperinsulinemia1
M Nagamani, C Osuampke, ME Kelver
The Journal of clinical endocrinology and metabolism 1999
Peripheral catecholamine alterations in adolescents with polycystic ovary syndrome
C Garcia-Rudaz, I Armando, G Levin, ME Escobar, M Barontini
Clinical Endocrinology 1998
Polycystic ovary syndrome: Current and future treatment paradigms
RS Legro
American Journal of Obstetrics and Gynecology 1998
Insights into hypothalamic-pituitary dysfunction in polycystic ovary syndrome
JE Hall, AE Taylor, FJ Hayes, WF Crowley
Journal of Endocrinological Investigation 1998
New routes in the polycystic ovary syndrome labyrinth: A way out?
P Moghetti, R Castello
Journal of Endocrinological Investigation 1998
Decline in Insulin-Like Growth Factor I Levels after Clomiphene Citrate Does Not Correct Hyperandrogenemia in Polycystic Ovary Syndrome
TM Fiad, TP Smith, SK Cunningham, TJ McKenna
The Journal of clinical endocrinology and metabolism 1998
The Ovarian Renin–Angiotensin System in Reproductive Physiology
Y Yoshimura
Frontiers in Neuroendocrinology 1997
8 Definition and significance of polycystic ovaries
D Dewailly
Baillière's Clinical Obstetrics and Gynaecology 1997
Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis*
A Dunaif
Endocrine reviews 1997
Determinants of Abnormal Gonadotropin Secretion in Clinically Defined Women with Polycystic Ovary Syndrome1
AE Taylor, B McCourt, KA Martin, EJ Anderson, JM Adams, D Schoenfeld, JE Hall
The Journal of clinical endocrinology and metabolism 1997
Relevance of the determination of ovarian volume in adolescent girls with menstrual disorders
LD Herter, JA Magalhäes, PM Spritzer
Journal of Clinical Ultrasound 1996
The role of intraovarian regulators in the aetiology of polycystic ovarian syndrome
G Almahbobi, AO Trounson
Reproductive Medicine Review 1996
Neuroendocrinology of the polycystic ovary syndrome
SG Soule
Baillière's Clinical Endocrinology and Metabolism 1996
Pituitary function is altered during the same cycle in women with polycystic ovary syndrome treated with continuous or cyclic oral contraceptives or a gonadotropin-releasing hormone agonist**Supported in part by educational grants from TAP Pharmaceuticals, Deerfield, Illinois (E.A.R.) and Organon, Inc., West Orange, New Jersey (E.A.R.)
EA Ruchhoft, KE Elkind-Hirsch, R Malinak
Fertility and Sterility 1996
Hypogonadotropic patients with ultrasonographically detected polycystic ovaries: endocrine response to pulsatile gonadotropin-releasing hormone
M Schachter, AH Balen, A Patel, HS Jacobs
Gynecological Endocrinology 1996
Clinical features and hormonal characteristics in a case of ovarian arrhenoblastoma
P Tita, A Spina, G Briguglia, A Magro, D Gallo, C Finocchiaro, G Padova, V Pezzino
Journal of Endocrinological Investigation 1996
Gonadotropin levels in women with polycystic ovary syndrome: Their relationship to body weight and insulin levels
G Tropeano, IP Vuolo, A Lucisano, I Liberale, A Barini, P Carfagna, G Caroli, E Menini, S dellAcqua
Journal of Endocrinological Investigation 1996
Estrogenic and antiestrogenic properties of clomiphene citrate in laboratory mice
A Kumar, PL Pakrasi
Journal of Biosciences 1995
Hypersecretion of luteinizing hormone in the polycystic ovary syndrome and a novel hormone 'gonadotrophin surge attenuating factor'
AH Balen
Journal of the Royal Society of Medicine 1995
The luteinizing hormone surge—the final stage in ovulation induction: modern aspects of ovulation triggering
EE Wallach, Z Shoham, M Schachter, E Loumaye, A Weissman, M MacNamee, V Insler
Fertility and Sterility 1995
Polycystic ovary syndrome — long-term metabolic consequences
E Dahlgren, PO Janson
International Journal of Gynecology & Obstetrics 1994
Reduced fertility and neuroendocrine dysfunction in women with epilepsy
C Nappi, R Meo, CD Carlo, A Estraneo, L Bilo
Gynecological Endocrinology 1994
Benefits of continuous physiological pulsatile gonadotropin-releasing hormone therapy in women with polycystic ovarian syndrome*†*Supported in part by Robert Wood Johnson Pharmaceuticals, New Brunswick, New Jersey.†Presented at the Society For Gynecologic Investigation, San Antonio, Texas, March 18 to 21, 1992
L Corenthal, SV Hagen, D Larkins, J Ibrahim, N Santoro
Fertility and Sterility 1994
Gynäkologische Endokrinologie und Fortpflanzungsmedizin
B Runnebaum, T Rabe
1994
Hypersecretion of luteinising hormone: a significant cause of infertility and miscarriage
AH Balen, SL Tan, HS Jacobs
BJOG: An International Journal of Obstetrics and Gynaecology 1993
Serum FSH bioactivity and response to acute gonadotrophin releasing hormone (GnRH) agonist stimulation in patients with polycystic ovary syndrome (PCOS) as compared to control groups
C Méchain, I Cédrin, C Pandian, A Lemay
Clinical Endocrinology 1993
Pulsatile Secretion of Serum Gonadotropins in Hirsute Women with and without Polycystic Ovarian Syndrome
SL Minanni, BL Wajchenberg, JA Marcondes, AM Cavaleiro-Luna, MA Fortes, MA Rego, BB Mendonca, DP Vezozzo, D Rodbard, D Giannella-Neto
Annals of the New York Academy of Sciences 1993
Interrelationship between Ultrasonography and Biology in the Diagnosis of Polycystic Ovarian Syndrome
D Dewailly, A Duhamel, Y Robert, Y Ardaens, R Beuscart, L Lemaitre, P Fossati
Annals of the New York Academy of Sciences 1993
New Approaches to the Study of the Neuroendocrine Abnormalities of Women with the Polycystic Ovarian Syndrome
JE Hall, AE Taylor, KA Martin, WF Crowley
Annals of the New York Academy of Sciences 1993
Can Women with Gonadotropin Levels Diagnostic of Polycystic Ovarian Syndrome Benefit from Therapy with Dopamine Agonists?
RF Harrison, M Synnott, R O'moore, M O'moore
Annals of the New York Academy of Sciences 1993
Gonadotropins in Polycystic Ovarian Syndrome
BC Fauser, FH Jong
Annals of the New York Academy of Sciences 1993
The Ovarian Renin-Angiotensin System in Polycystic Ovarian Syndrome
A Palumbo, ML Carcangiu, L Roa, J Pepperell, G Pourmotabbed, F Naftolin
Annals of the New York Academy of Sciences 1993
Pure FSH alone induces ovulation and subsequent pregnancy in the mouse resulting in fetal development
VC Rice, K Zusmanis, H Malter, D Mitchell-Leef
Life Sciences 1993
Treatment of polycystic ovarian disease during adolescence with ethinylestradiol/cyproterone acetate versus a d-tr-6-lhrh analog
G Creatsas, E Hassan, E Deligeoroglou, G Tolis, D Aravantinos
International Journal of Gynecology & Obstetrics 1993
Immunohistochemical localization of renin and angiotensin in the ovary: comparison between normal women and patients with histologically proven polycystic ovarian disease**Supported by grant HD 22970 from the National Institutes of Health, Bethesda, Maryland, and by the 1990 to 1991 Mead-Johnson Fellowship (A.P.),
A Palumbo, G Pourmotabbed, ML Carcangiu, P Andrade-Gordon, L Roa, A DeCherney, F Naftolin
Fertility and Sterility 1993
The concomitant release of androstenedione with Cortisol and luteinizing hormone pulsatile releases distinguishes adrenal from ovarian hyperandrogenism
AD Genazzani, F Petraglia, F Pianazzi, C Volpogni, AR Genazzani
Gynecological Endocrinology 1993
Altered luteinizing hormone pulse frequency in early follicular phase of the menstrual cycle with luteal phase defect patients in women**Supported in part by National Institutes of Health General Clinical Research Center grant RR-00051, Bethesda, Maryland
BY Suh, G Betz
Fertility and Sterility 1993
Effects of ovarian surgery on the dopaminergic and opioidergic control of gonadotropin and prolactin secretion in women with polycystic ovarian disease
A Szilágyi, R Hole, J Keckstein, WG Rossmanith
Gynecological Endocrinology 1993
Polycystic Ovarian Disease as a Neuroendocrine Disorder of the Female Reproductive Axis
JE Hall
Endocrinology and metabolism clinics of North America 1993
17β-Oestradiol, androstenedione and inhibin levels in fluid from individual follicles of normal and polycystic ovaries, and in ovaries from androgen treated female to male transsexuals
TD Pache, WC Hop, FH Jong, RA Leerentveld, H Geldorp, TM Kamp, LJ Gooren, BC Fauser
Clinical Endocrinology 1992
Which hormone tests for the diagnosis of polycystic ovary syndrome?
S Robinson, DA Rodin, A Deacon, MJ Wheeler, RN Clayton
BJOG: An International Journal of Obstetrics and Gynaecology 1992
Polycystic ovarian syndrome and associated hirsutism in the adolescent
HD McClamrock, EY Adashi
Adolescent and Pediatric Gynecology 1992
Assessment of clinical hyperandrogenism in adolescent girls
SF Siegel, DN Finegold, PJ Murray, PA Lee
Adolescent and Pediatric Gynecology 1992
Vaginal progesterone administration in physiological doses normalizes raised luteinizing hormone levels in patients with polycystic ovarian syndrome
HM Buckler, M Bangah, DL Healy, HG Burger
Gynecological Endocrinology 1992
Women with polycystic ovary syndrome wedge resected in 1956 to 1965: a long-term follow-up focusing on natural history and circulating hormones**Supported by grants from the Faculty of Medicine, University of Göteborg, The Göteborg Medical Society and the Research and Development Foundation, Bohuslandstinget, Göteborg, Sweden
E Dahlgren, S Johansson, G Lindstedt, F Knutsson, A Odén, PO Janson, LÅ Mattson, N Crona, PA Lundberg
Fertility and Sterility 1992
Body weight, hyperinsulinemia, and gonadotropin levels in the polycystic ovarian syndrome: evidence of two distinct populations
PO Dale, T Tanbo, S Vaaler, T Åbyholm
Fertility and Sterility 1992
Serum androgen and gonadotropin levels decline after progestogen-induced withdrawal bleeding in oligomenorrheic women with or without polycystic ovaries**Supported by grants from the Paulo Foundation, Helsinki, Finland, and the Foundation of the University of Turku, Turku, Finland
L Anttila, P Koskinen, HL Kaihola, R Erkkola, K Irjala, K Ruutiainen
Fertility and Sterility 1992
Puberty and polycystic ovarian syndrome: the insulin/insulin-like growth factor I hypothesis
EE Wallach, F Nobels, D Dewailly
Fertility and Sterility 1992
Biologic Rhythms in Clinical and Laboratory Medicine
Y Touitou, E Haus
1992
Modes of Action of GnRH and GnRH Analogs
WF Crowley, PM Conn
1992
The diagnosis of polycystic ovaries in women with oligo-amenorrhoea: predictive power of endocrine tests
R Fox, E Corrigan, PA Thomas, MG Hull
Clinical Endocrinology 1991
Gonadotrophin Surge Attenuating Factor: a missing link in the control of LH secretion?
AH Bolen, HS Jacobs
Clinical Endocrinology 1991
The impact of ovarian laser surgery on the gonadotrophin secretion in women with polycystic ovarian disease
WG Rossmanith, J Keckstein, K Spatzler, C Lauritzen
Clinical Endocrinology 1991
Interactions between Insulin and Insulin-like Growth Factor I in the Pathogenesis of Polycystic Ovarian Disease
W Urdl, G Desoye, B Schmon, HM Hofmann, G Ralph
Annals of the New York Academy of Sciences 1991
Transvaginal sonography and abnormal ovarian appearance in menstrual cycle disturbances
TD Pache, WC Hop, JW Wladimiroff, J Schipper, BC Fauser
Ultrasound in Medicine & Biology 1991
Introduction to Clinical Reproductive Endocrinology
GC Lachelin
Introduction to Clinical Reproductive Endocrinology 1991
Proceedings of the 1990 Laurentian Hormone Conference
AE Boyd, L Aguilar-Bryan, J Bryan, DL Kunze, L Moss, DA Nelson, AS Rajan, H Raef, H Xiang, GC Yaney
Proceedings of the 1990 Laurentian Hormone Conference 1991
Three types of polycystic ovarian syndrome in relation to androgenic function**Supported in part by grant no. 01570927 for Scientific Research from the Ministry of Education, Tokyo, Japan
I Takai, S Taii, K Takakura, T Mori
Fertility and Sterility 1991
Is the inappropriate gonadotropin secretion of patients with polycystic ovary syndrome similar to that of patients with adult-onset congenital adrenal hyperplasia?
JH Levin, E Carmina, RA Lobo
Fertility and Sterility 1991
Abnormal pattern of luteinizing hormone pulsatility in women with epilepsy
L Bilo, R Meo, R Valentino, GA Buscaino, S Striano, C Nappi
Fertility and Sterility 1991
Clinical features and circulating gonadotropin, insulin, and androgen interactions in women with polycystic ovarian disease*
L Anttila, YQ Ding, K Ruutiainen, R Erkkola, K Irjala, I Huhtaniemi
Fertility and Sterility 1991
Adjusting the dose to the individual response of the patient during the induction of ovulation with pulsatile gonadotropin-releasing hormone
V Mais, GB Melis, F Strigini, D Antinori, A Ruggiero, P Fioretti
Fertility and Sterility 1991
Response of gonadotropins to pituitary stimulation with luteinizing hormone releasing hormone is a more specific than sensitive parameter for the polycystic ovary syndrome
T Steck, H Wernze, PJ Albert
Gynecological Endocrinology 1991
Gießener Gynäkologische Fortbildung 1991
W Künzel, M Kirschbaum
1991
Changes in circulating hormone levels after ovarian wedge resection in patients with polycystic ovary syndrome
A Szilágyi, W Rossmanith, T Csermely, I Csaba
Archives of Gynecology and Obstetrics 1990
Plasma Catecholamine Metabolites and Polycystic Ovary Syndrome
K Yoshino, K Takahashi, A Nishigaki, Y Eda, M Kitao
Asia-Oceania Journal of Obstetrics and Gynaecology 1990
Polycystic ovary syndrome: Abnormalities and management with pulsatile gonadotropin-releasing hormone and gonadotropin-releasing hormone analogs
M Filicori, C Flamigni, E Campaniello, MC Meriggiola, L Michelacci, A Valdiserri, P Ferrari
American Journal of Obstetrics and Gynecology 1990
Serum 5-androstene-3β,17β-DIOL sulphate and 5α-androstane-3α,17β-DIOL sulphate in hirsute females with polycystic ovarian disease
J Montalto, JW Funder, AB Yong, HE Davies, JF Connelly
Journal of Steroid Biochemistry 1990
The effect of metoclopramide on ovarian responsiveness to gonadotropin administration in patients with severe polycystic ovarian syndrome
A Lissak, M Dirnfeld, Y Sorokin, L Kahana, H Abramovici, Y Koch
Fertility and Sterility 1990
Are estrogen assays essential for monitoring gonadotropin stimulant therapy?
P Hardiman, M Thomas, V Osgood, V Vlassopoulou, J Ginsburg
Gynecological Endocrinology 1990
Polycystic ovarian disease: A challenge and controversy
V Insler, B Lunenfeld
Gynecological Endocrinology 1990
Current concepts of β-endorphin physiology in female reproductive dysfunction
EE Wallach, DB Seifer, RL Collins
Fertility and Sterility 1990
Dysregulation of cytochrome P450c17α as the cause of polycystic ovarian syndrome**Supported in part by grants HD-06308 and Rr-00055 from the United States Public Health Service, Bethesda, Maryland
RL Rosenfield, RB Barnes, JF Cara, AW Lucky
Fertility and Sterility 1990
The effect of laparoscopic treatment of polycystic ovarian disease by CO2-laser or Nd:YAG laser
G Keckstein, W Rossmanith, K Spatzier, V Schneider, K Brchers, R Steiner
Surgical Endoscopy 1990
POLYCYSTIC OVARY SYNDROME: A CHANGING PERSPECTIVE
S Franks
Clinical Endocrinology 1989
OPIOIDERGIC REGULATION OF LH PULSATILITY IN WOMEN WITH POLYCYSTIC OVARY SYNDROME
SL Berga, AS Yen
Clinical Endocrinology 1989
7 Laparoscopic treatment of polycystic ovarian syndrome
J Keckstein
Baillière's Clinical Obstetrics and Gynaecology 1989
In vivo and in vitro effects of androgens on rat ovarian granulosa cells
E Anderson
American Journal of Obstetrics and Gynecology 1989
Importance of echographic and endocrine monitoring for the assessment of ovulation by follicle stimulating hormone in polycystic ovarian disease
A Caruso, A Lanzone, AM Fulghesu, R Apa, C Guida, S Mancuso
International Journal of Gynecology & Obstetrics 1989
Pathophysiology of polycystic ovary syndrome
P Mauvais-Jarvis, C Bricaire
Journal of Steroid Biochemistry 1989
Pituitary-Ovarian Responses to Nafarelin Testing in the Polycystic Ovary Syndrome
RB Barnes, RL Rosenfield, S Burstein, DA Ehrmann
New England Journal of Medicine 1989
Androgens amplify β-adrenergic and FSH stimulation of granulosa cells
SL Young, MH Melner
Steroids 1989
Endocrine dynamics during pulsatile GnRH administration in patients with hypothalamic amenorrhea and polycystic ovarian disease
WG Rossmanith, U Wirth, R Benz, AS Wolf
Gynecological Endocrinology 1989
Induction of ovulation with clomiphene citrate in women with polycystic ovary syndrome: the difference between responders and nonresponders*
DW Polson, DS Kiddy, HD Mason, S Franks
Fertility and Sterility 1989
GnRH-agonist therapy in women with the polycystic ovarian syndrome: Effects on ovarian volume and on gonadotropin and sex steroid levels
PO Dale, T Tanbo, E Haug, T Arbyholm
Gynecological Endocrinology 1989
Induction of ovulation with subcutaneous pulsatile gonadotropin-releasing hormone: correlation with body weight and other parameters
AK Thomas, J Mander, J Hale, J Walstab, MS Forrest
Fertility and Sterility 1989
Effects of gonadotropin-releasing hormone (GnRH) agonist on pituitary and ovarian responses to pulsatile GnRH therapy in polycystic ovarian disease*†
ES Surrey, D Ziegler, JK Lu, RJ Chang, HL Judd
Fertility and Sterility 1989
The luteinizing hormone surge: timing and characteristics in the plasma and urine after clomiphene citrate treatment*†
BR Hecht, FS Khan-Dawood, MY Dawood
Fertility and Sterility 1989
Ovulation induction with pulsatile luteinizing hormone-releasing hormone in women with clomiphene citrate-resistant polycystic ovary-like disease: endocrine results*
CW Burger, PG Hompes, TJ Korsen, J Schoemaker
Fertility and Sterility 1989
A pharmacodynamic comparison of human urinary follicle-stimulating hormone and human menopausal gonadotropin in normal women and polycystic ovary syndrome**Supported in part by grant MO1-RR-43 from the General Clinical Research Centers Program of the Division of Research Resources, National Institutes of Health, Bethesda, Maryland, and by a grant from Serono Laboratories, Inc., Norwell, Massachusetts
RE Anderson, JM Cragun, RJ Chang, FZ Stanczyk, RA Lobo
Fertility and Sterility 1989
Influence of the Host on Tumor Development
RB Herberman
1989
Polycystic ovarian disease: Endocrinological parameters with specific reference to growth hormone and somatomedin-C
W Urdl
Archives of Gynecology and Obstetrics 1988
EVIDENCE FOR A HYPOTHALAMIC ALTERATION OF CATECHOLAMINE METABOLISM IN POLYCYSTIC OVARY SYNDROME
R Paradisi, G Grossi, S Venturoli, M Capelli, E Porcu, R Fabbri, R Pasquali, C Flamigni
Clinical Endocrinology 1988
EPISODIC PULSATILE SECRETION OF FSH, LH, PROLACTIN, OESTRADIOL, OESTRONE, AND LH CIRCADIAN VARIATIONS IN POLYCYSTIC OVARY SYNDROME
S Venturoli, E Porcu, R Fabbri, O Magrini, L Gammi, R Paradisi, M Forcacci, R Bolzani, C Flamigni
Clinical Endocrinology 1988
Reproductive Endocrine Disorders in Women with Primary Generalized Epilepsy
L Bilo, R Meo, C Nappi, L Annunziato, S Striano, AM Colao, B Merola, GA Buscaino
Epilepsia 1988
ADVANCES IN REPRODUCTIVE MEDICINE: AUSTRALIAN CONTRIBUTIONS
HG Burger, HM Buckler, HW Baker, DL Healy, GT Kovacs
Australian and New Zealand Journal of Medicine 1988
Polycystic ovaries in childhood
CG Brook, HS Jacobs, R Stanhope
British medical journal (Clinical research ed.) 1988
Pulsatile secretion of luteinizing hormone in adolescents with hyperandrogenism
D Apter, R Siegberg, T Laatikainen
Adolescent and Pediatric Gynecology 1988
Pathogenesis and Treatment of Polycystic Ovary Syndrome
TJ McKenna
New England Journal of Medicine 1988
The theory and practice of ovulation induction with gonadotropin-releasing hormone
RL Reid, R Fretts, DA van Vugt
American Journal of Obstetrics and Gynecology 1988
Case 22-1988: A 13-Year-Old Girl with Secondary Amenorrhea, Obesity, Acanthosis Nigricans, and Hirsutism
RC Cabot, RE Scully, EJ Mark, WF McNeely, BU McNeely, A Dunaif, RE Scully
New England Journal of Medicine 1988
The role of hyperinsulinemia in the pathogenesis of ovarian hyperandrogenism
EE Wallach, RL Barbieri, S Smith, KJ Ryan
Fertility and Sterility 1988
The source(s) of estrogen production in hirsute women with polycystic ovarian disease as determined by simultaneous adrenal and ovarian venous catheterization
BL Wajchenberg, SS Achando, MM Mathor, CE Czeresnia, DG Neto, MA Kirschner
Fertility and Sterility 1988
Secretory dynamics of bioactive and immunoreactive prolactin in polycystic ovary syndrome**Supported in part by the National institute of Health grants HD-17519 and GCRC RR-43
RE Anderson, Z Ben-Rafael, GL Flickinger, F Meloni, RB Barnes, GF Rosen, RA Lobo
Fertility and Sterility 1988
Evaluation of the Infertile Couple
RS Swerdloff, C Wang, FR Kandeel
Endocrinology and metabolism clinics of North America 1988
The Role of Neurotransmitters and Opioids in Polycystic Ovarian Syndrome
RA Lobo
Endocrinology and metabolism clinics of North America 1988
Polycystic Ovarian Disease: Animal Models
DK Mahajan
Endocrinology and metabolism clinics of North America 1988
Hypothalamic-Pituitary Dysfunction in Polycystic Ovarian Disease
EY Adashi
Endocrinology and metabolism clinics of North America 1988
Evaluation and Therapy of Polycystic Ovarian Syndrome
R Loy, MM Seibel
Endocrinology and metabolism clinics of North America 1988
The Adrenal Gland
CR Kannan
1988
EFFECT OF BROMOCRIPTINE ON LH PULSATILITY IN THE POLYCYSTIC OVARY SYNDROME
AJ Chapman, MD Wilson, M Obhrai, RS Sawers, SS Lynch, JP Royston, RN Clayton
Clinical Endocrinology 1987
Plasma Prolactin and Dehydroepiandrosterone Sulfate Levels in Polycystic Ovarian Disease
JY Lee, BK Yoon, SY Moon, JG Kim, YS Chang
Asia-Oceania Journal of Obstetrics and Gynaecology 1987
Polycystic ovary syndrome: an enigma awaiting solution
M Schwartz, PR Gindoff, R Jewelewicz
Bulletin of the New York Academy of Medicine 1987
The consequences of hyperandrogenism in young women
DR London
Journal of the Royal Society of Medicine 1987
Ovulation induction with pulsatile human menopausal gonadotropin (HMG) administration
S Friedler, YZ Diamant
European Journal of Obstetrics & Gynecology and Reproductive Biology 1987
Plasma β-endorphin, β-lipotropin and corticotropin in polycystic ovarian disease
T Laatikainen, K Salminen, T Virtanen, D Apter
European Journal of Obstetrics & Gynecology and Reproductive Biology 1987
Hormones
AW Norman, G Litwack
Hormone Research 1987
Androgen and insulin response to an oral glucose challenge in hyperandrogenic women**Presented at the forty-second annual meeting of The American Fertility Society, and the eighteenth annual meeting of the Canadian Fertility and Andrology Society, September 27 to October 2, 1986, Toronto, Ontario, Canada
S Smith, VA Ravnikar, RL Barbieri
Fertility and Sterility 1987
The evolution of polycystic ovaries in a girl with hypogonadotropic hypogonadism before puberty and during puberty induced with pulsatile gonadotropin-releasing hormone
R Stanhope, J Adams, JP Pringle, HS Jacobs, CG Brook
Fertility and Sterility 1987
Pulsatile intravenous gonadotropin-releasing hormone for ovulation-induction in infertile women. II. Analysis of follicular and luteal phase responses**Presented in part at the Seventh International Congress of Endocrinology, Abstract 897, Quebec City, Quebec, Canada, July 1 to 7, 1984
RP Jansen, DJ Handelsman, LM Boylan, A Conway, RP Shearman, IS Fraser, JC Anderson
Fertility and Sterility 1987
Gonadotropin-releasing hormone-induced changes in testosterone secretion in normal women**Supported by the National Institutes of Health grants R01 HD 18967-02 (M.R.S.), P50 HD 12629-07 (W.J.B.), RO1 HD 12625-08 (R.A.S.), Clinical Research Center grant RR-37, and by the Veterans Administration
MR Soules, DK Clifton, RA Steiner, NL Cohen, WJ Bremner
Fertility and Sterility 1987
Induction of ovulation by intermittent intravenous purified follicle-stimulating hormone in polycystic ovarian disease
A Lanzone, AM Fulghesu, M Conte, R Apa, A Caruso, S Mancuso
Fertility and Sterility 1987
Regulation of Ovarian and Testicular Function
VB Mahesh, DS Dhindsa, E Anderson, SP Kalra
1987
Menstrual Disorders in the Adolescent Age Group
J Kustin, RW Rebar
Primary care 1987
Polycystic Ovarian Disease
PR Gindoff, R Jewelewicz
Obstetrics and Gynecology Clinics of North America 1987
Endocrine evaluation of forty female-to-male transsexuals: Increased frequency of polycystic ovarian disease in female transsexualism
W Futterweit, RA Weiss, RM Fagerstrom
Archives of Sexual Behavior 1986
STUDIES OF PROLACTIN SECRETION IN POLYCYSTIC OVARY SYNDROME
AP Murdoch, W Dunlop, P Kendall-Taylor
Clinical Endocrinology 1986
DOES TESTOSTERONE AFFECT THE NORMAL MENSTRUAL CYCLE?
P Dewis, M Newman, WA Ratcliffe, DC Anderson
Clinical Endocrinology 1986
Effects of obesity on gonadotropin secretion in patients with polycystic ovarian disease
R Paradisi, S Venturoli, R Pasquali, M Capelli, E Porcu, R Fabbri, C Flamigni
Journal of Endocrinological Investigation 1986
Gonadotropin-Releasing Hormone: Role of Pulsatile Secretion in the Regulation of Reproduction
JS Flier, LH Underhill, JC Marshall, RP Kelch
New England Journal of Medicine 1986
Hirsutism in Young Adolescent Girls
J Kustin, RW Rebar
Pediatric Annals 1986
Dynamic testing in reproductive endocrinology
EE Wallach, WD Schlaff
Fertility and Sterility 1986
The effects of long-term androgen treatment on the ovary
H Amirikia, RT Savoy-Moore, AS Sundareson, KS Moghissi
Fertility and Sterility 1986
Prevalence of and markers for the attenuated form of congenital adrenal hyperplasia and hyperprolactinemia masquerading as polycystic ovarian disease*
F Benjamin, S Deutsch, H Saperstein, VL Seltzer
Fertility and Sterility 1986
Gynecologic Endocrinology
JJ Gold, JB Josimovich
1986
Clomiphene citrate can mimic the augmentative (positive) but not the depressing (negative) effect of estradiol on the LHRH-stimulated release of LH and FSH by the pituitary gland of the long-term ovariectomized rat
GA Schuiling, N Pols-Valkhof, TR Koiter
Experientia 1985
Hormonal response to electrocautery of the ovary in patients with polycystic ovarian disease
A Aakvaag, H Gjonnaess
BJOG: An International Journal of Obstetrics and Gynaecology 1985
The dynamic interaction between steroids and gonadotropins in the mammalian ovulatory cycle
VB Mahesh
Neuroscience & Biobehavioral Reviews 1985
Polycystic ovarian disease
E Schriock, MC Martin, RB Jaffe
The Western journal of medicine 1985
5 The investigation of female gonadal dysfunction
DV Morris, J Adams, HS Jacobs
Clinics in Endocrinology and Metabolism 1985
Prolactin pulsatility in polycystic ovarian disease
T Laatikainen, A Tulenheimo
Journal of Endocrinological Investigation 1985
The effect of acute exercise on pulsatile release of luteinizing hormone in women runners
DC Cumming, MM Vickovic, SR Wall, MR Fluker, AN Belcastro
American Journal of Obstetrics and Gynecology 1985
Hormonal parameters and conception rate during five different types of treatment of polycystic ovarian syndrome
L Rönnberg, P Ylöstalo, A Ruokonen
International Journal of Gynecology & Obstetrics 1985
Acute ovarian responses to a long-acting agonist of gonadotropin-releasing hormone in ovulatory women and women with polycystic ovarian disease**Supported in part by United States Public Health Service grants CA-23093, AG-01512, RR-5354, RR-865, and HD-13527
J DeFazio, DR Meldrum, JK Lu, WW Vale, JE Rivier, HL Judd, RJ Chang
Fertility and Sterility 1985
Ovulation induction with gonadotropin-releasing hormone
EE Wallach, HA Zacur
Fertility and Sterility 1985
Ovulation induction with pulsatile gonadotropin-releasing hormone administration in patients with polycystic ovarian syndrome**Supported in part by General Clinical Research Centers Program, Division of Research Resources, National Institutes of Health grant RR 30.††Supported in part by a grant from Ayerst Laboratories, New York, New York
SJ Ory, SN London, L Tyrey, CB Hammond
Fertility and Sterility 1985
Medroxiprogesterona en el manejo de S.O.A
GG T., EH C., RE N.
1985
Ovulatory Disorders in Women with Polycystic Ovary Syndrome
S Franks, J Adams, H Mason, DA Polson
1985
CYCLE INITIATION IN AMENORRHOEA; THE EFFECT OF PROGESTERONE AND OESTROGEN ADMINISTRATION ON THE PULSATILE RELEASE OF GONADOTROPHINS
MA Sheikh, BG Molloy, C Chapman, RE Oakey, KW Hancock, MR Glass
Clinical Endocrinology 1984
THE ACUTE EFFECTS OF A DOPAMINE ANTAGONIST (DOMPERIDONE) ON LUTEINISING HORMONE, FOLLICULE STIMULATING HORMONE, PROLACTIN AND THYROTROPHIN SECRETION IN POLYCYSTIC OVARIAN SYNDROME: DIFFERENTIAL EFFECT OF OVULATION
AP Murdoch, W Dunlop, P Kendall-Taylor, MJ Watson
Clinical Endocrinology 1984
EVIDENCE FOR DECREASED ENDOGENOUS DOPAMINE AND OPIOID INHIBITORY INFLUENCES ON LH SECRETION IN POLYCYSTIC OVARY SYNDROME
DC Cumming, RL Reid, ME Quigley, RW Rebar, SS Yen
Clinical Endocrinology 1984
Endogenous opioid peptides and the menstrual cycle
M Ferin
Trends in Neurosciences 1984
Pathological mechanisms in polycystic ovary syndrome: modulation of LH pulsatility by progesterone
BG Molloy, MA el Sheikh, C Chapman, RE Oakey, KW Hancock, MR Glass
BJOG: An International Journal of Obstetrics and Gynaecology 1984
Endocrine Disorders
LH Rees
Endocrine Disorders 1984
Hormonal characteristics of women with clinical features of the polycystic ovary syndrome
MJ Heineman, CM Thomas, WH Doesburg, R Rolland
European Journal of Obstetrics & Gynecology and Reproductive Biology 1984
The effects of superovulatory doses of clomiphene citrate on spontaneous luteinizing hormone peaks in regularly ovulating women
IH Thorneycroft, M Bustillo, JA Simon, JE Buster
American Journal of Obstetrics and Gynecology 1984
Evidence for altered catecholamine metabolism in polycystic ovary syndrome
D Shoupe, RA Lobo
American Journal of Obstetrics and Gynecology 1984
Induction of Ovulation and Fertility in Amenorrheic Women by Pulsatile Low-Dose Gonadotropin-Releasing Hormone
DM Hurley, R Brian, K Outch, J Stockdale, A Fry, C Hackman, I Clarke, HG Burger
New England Journal of Medicine 1984
Pituitary and ovarian responses to LHRH stimulation in women with clinical features of the polycystic ovary syndrome
MJ Heineman, CM Thomas, WH Doesburg, R Rolland
European Journal of Obstetrics & Gynecology and Reproductive Biology 1984
The control of bioactive luteinizing hormone secretion in women with polycystic ovary syndrome
RA Lobo, D Shoupe, SP Chang, J Campeau
American Journal of Obstetrics and Gynecology 1984
Polycystic ovarian disease: current concepts of pathophysiology and therapy
EE Wallach, PJ Coney
Fertility and Sterility 1984
Clomiphene citrate in an in vitro fertilization program: hormonal comparisons between 50- and 150-mg daily dosages**Supported in part by University of Texas Biomedical Research Support grant 2 S07 RR 05745-09
MM Quigley, AS Berkowitz, SA Gilbert, DP Wolf
Fertility and Sterility 1984
S.O.A ¿Una manifestación clínico-patológica de diferentes estados hiperandrogénicos?
GG T., EH C., RM N., ER V.
1984
Progress in Brain Research
DE van Epps, L Saland, C Taylor, RC Williams
Progress in brain research 1983
Obesity, serum steroid levels, and pulsatile gonadotropin secretion in polycystic ovarian disease
T Laatikainen, A Tulenheimo, B Andersson, J Kärkkäinen
European Journal of Obstetrics & Gynecology and Reproductive Biology 1983
Polycystic-Ovary Syndrome — What Is It?
JL Vaitukaitis
New England Journal of Medicine 1983
Evidence for adrenal and/or ovarian dysfunction as a possible etiology of idiopathic hirsutism
A Bouallouche, JL Brerault, J Fiet, J Julien, C Vermeulen, G Cathelineau
American Journal of Obstetrics and Gynecology 1983
Psychological stress and increases in urinary norepinephrine metabolites, platelet serotonin, and adrenal androgens in women with polycystic ovary syndrome
RA Lobo, LR Granger, WL Paul, U Goebelsmann, DR Mishell
American Journal of Obstetrics and Gynecology 1983
Elevated bioactive luteinizing hormone in women with the polycystic ovary syndrome**Supported in part by grants from the Ford Foundation (690-0650A) and the National Institute of Child Health and Development (HD-00401)
RA Løbo, OA Kletzky, JD Campeau, GS diZerega
Fertility and Sterility 1983
Adolescent Gynecology
AM Bongiovanni
1983
Case 25-1982: Amenorrhea, Virilization, and Hyperpigmentation in a 15-Year-Old Girl
RC Cabot, RE Scully, EJ Mark, BU McNeely
New England Journal of Medicine 1982
Effect of androgen excess on inappropriate gonadotropin secretion as found in the polycystic ovary syndrome
RA Lobo, U Goebelsmann
American Journal of Obstetrics and Gynecology 1982
The agonistic-antagonistic properties of clomiphene: A review
JH Clark, BM Markaverich
Pharmacology & Therapeutics 1981
Polycystic Ovarian Disease — Current Concepts
JS Biggs
The Australian and New Zealand Journal of Obstetrics and Gynaecology 1981
Characteerization of basal estrogen and androgen levels and gonadotropin release patterns in the obese adolescent female
ED Kaufman, J Mosman, M Sutton, MB Harris, CW Carmichael, SS Yen
The Journal of Pediatrics 1981
Induction of ovulation by combined clomiphene citrate and dexamethasone treatment in clomiphene citrate nonresponders
YZ Diamant, S Evron
European Journal of Obstetrics & Gynecology and Reproductive Biology 1981
Evaluation of Hirsutism and Hyperandrogenemia
EE Wallach, GB Maroulis
Fertility and Sterility 1981
Hirsutism: Implications, etiology, and management
R Hatch, RL Rosenfield, MH Kim, D Tredway
American Journal of Obstetrics and Gynecology 1981
Polycystic Ovaries
M Katz
1981
REVIEW ARTICLE: THE POLYCYSTIC OVARY SYNDROME
SS Yen
Clinical Endocrinology 1980
Is Diagnostic Gonadotrophs Stimulation Useful?
RL Wu, RP Shearman, IS Fraser
The Australian and New Zealand Journal of Obstetrics and Gynaecology 1980
Oligomenorrhea in adolescent girls
SJ Emans, E Grace, DP Goldstein
The Journal of Pediatrics 1980
Case 10-1980: A 29-Year-Old Woman with Amenorrhea and Hirsutism
RC Cabot, RE Scully, JJ Galdabini, BU McNeely, C Longcope, SJ Robboy
New England Journal of Medicine 1980
Role of Prolactin in the Polycystic Ovary Syndrome
E Pozo, P Falaschi
Scottish Medical Journal 1980
Síndrome de ovario anarogénico
GG T., AL Zuluaga
1980
Estrogen-Androgen Balance in Hirsutism
CH Wu
Fertility and Sterility 1979
Peripheral steroid-gonadotropin interactions and diagnostic significance of double-stimulation tests with luteinizing hormone-releasing hormone in polycystic ovarian disease
L Moltz, A Römmler, U Schwartz, F Bidlingmaier, J Hammerstein
American Journal of Obstetrics and Gynecology 1979
SERUM PROLACTIN AND GONADOTROPHIN LEVELS BEFORE AND AFTER LUTEINIZING HORMONE-RELEASING HORMONE IN THE INVESTIGATION OF AMENORRHOEA
T Bergh, SJ Nillius, L Wide
BJOG: An International Journal of Obstetrics and Gynaecology 1978
Gynecologic problems of adolescent girls
DR Hollingsworth, AK Kreutner
Current Problems in Pediatrics 1978
Pituitary response to bolus and continuous intravenous infusion of luteinizing hormone-releasing factor in normal women and women with polycystic ovarian syndrome
RH Mortimer, M Lev-Gur, R Freeman, N Fleischer
American Journal of Obstetrics and Gynecology 1978
The Year in Endocrinology 1977
SH Ingbar
1978
Clinical Neuroendocrinology
CR Edwards
Clinical Neuroendocrinology 1977
Hypothalamic Peptide Hormones and Pituitary Regulation
JC Porter
1977
Obesity and Diabetes
M Smith, R Levine
Medical Clinics of North America 1964

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