Citations to this article

Surface immunoglobulin on activated human peripheral blood thymus-derived cells.
T L Whiteside, B S Rabin
T L Whiteside, B S Rabin
Published March 1, 1976
Citation Information: J Clin Invest. 1976;57(3):762-771. https://doi.org/10.1172/JCI108335.
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Research Article

Surface immunoglobulin on activated human peripheral blood thymus-derived cells.

Abstract

Human peripheral blood lymphocytes grown in vitro were stimulated with nonspecific mitogens and in mixed lymphocyte culture. The presence of IgM and thymus (T) surface markers on large and small lymphocytes was investigated by immunofluorescence and correlated with spontaneous rosette formation. All stimulated large lymphocytes formed spontaneous rosettes and all except pokeweed mitogen (PWM)-stimulated large lymphocytes had IgM and T markers. IgG, IgA, and light chain determinants were only detected on PWM-induced large lymphocytes. Thus, surface markers expressed on activated human lymphocytes may differ for different mitogens. IgM was always present on large cells which had the T markers, and it cannot be used to identify a lymphocyte as a bone marrow-derived (B) cell. Due to the overlap of surface markers, the classification into B and thymus-derived (T) cells ought to be restricted to functional phenomena of antibody-production or cell-mediated immunity.

Authors

T L Whiteside, B S Rabin

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Total citations by year

Year: 2020 1986 1984 1983 1982 1981 1980 1979 1978 1977 1976 Total
Citations: 1 1 1 1 2 1 6 1 6 10 3 33
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Citations to this article (33)

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