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Citations to this article

Quantitation of immunocompetence in Hodgkin's disease.
G B Faguet
G B Faguet
Published October 1, 1975
Citation Information: J Clin Invest. 1975;56(4):951-957. https://doi.org/10.1172/JCI108175.
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Research Article Article has an altmetric score of 3

Quantitation of immunocompetence in Hodgkin's disease.

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Abstract

In vitro cellular immunocompetence was investigated on 35 patients with Hodgkin's disease by studying their in vitro lymphocyte responsiveness to full range stimulation achieved by a spectrum of phytohemagglutinin concentrations. When compared to the normal lymphocyte profile elicited from 35 control subjects, the Hodgkin's patterns of response enabled the identification of a quantifiable lymphocyte defect present in most patients regardless of their clinical status. Increasing severity of this defect was found with progression of the disease and was most pronounced in patients with skin anergy and absolute lymphopenia. The marked abnormality observed in patients restudied after intensive therapy returned towards normal in patients achieving a long lasting, unmaintained complete remission. The data suggest the early presence of an intrinsic functional lymphocyte defect, increasing severity of which may lead to progressive immunoincompetence, reflected to vitro by imparied lymphocyte responsiveness and in vivo by skin anergy and ultimately lymphopenia.

Authors

G B Faguet

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Total citations by year

Year: 1995 1993 1991 1987 1986 1984 1983 1982 1981 1980 1979 1978 1977 1976 Total
Citations: 1 1 2 2 4 3 3 3 6 6 5 4 5 3 48
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (48)

Title and authors Publication Year
Infectious complications and immunodeficiency in patients with human T-cell lymphotropic virus I-associated adult T-cell leukemia/lymphoma
JD White, SL Zaknoen, C Kasten-Sportès, LE Top, L Navarro-Roman, DL Nelson, TA Waldmann
Cancer 1995
Characterization of lung squamous cell carcinoma-derived t-cell suppressive factor
I Yoshino, G Kimura, T Yano, M Miyamoto, K Nomoto, K Yamada, Y Kajii, K Onodera, T Ishida, K Sugimachi
Cancer 1993
Characterization and purification of an immunosuppressive factor produced by a small cell lung cancer cell line
T Ikeda, T Masuno, T Ogura, M Watanabe, T Shirasaka, H Hara, Y Tanio, I Kawase, S Kishimoto
Japanese journal of cancer research : Gann 1991
Characterization and Purification of an Immunosuppressive Factor Produced by a Small Cell Lung Cancer Cell Line
Ikeda T, Masuno T, Ogura T, Watanabe M, Shirasaka T, Kara H, Tanio Y, Kawase I, Kishimoto S
Japanese journal of cancer research : Gann 1991
Effect of incidental appendectomy on the development of wound infection in patients undergoing staging laparotomy for Hodgkin's disease
DM Morris, DD Coker, JJ Coleman, PH Wiemik, EG Elias
The American Journal of Surgery 1987
Immunologic Status of Patients in Remission from Hodgkin’s Disease and Disseminated Malignancies
CM Shapiro, E Beckmann, N Christiansen, JD Bitran, M Kozloff, AA Billings, MC Telfer
The American Journal of the Medical Sciences 1987
Five-year survival in Hodgkin's disease. The prospective value of immune status at diagnosis
RE van Rijswijk, AJ de Meijer, JP Sybesma, L Kater
Cancer 1986
Decreased adenosine deaminase (ADA) and 5′nucleotidase (5NT) activity in peripheral blood T cells in hodgkin disease
JL Murray, R Perez-Soler, D Bywaters, EM Hersh
American Journal of Hematology 1986
Decreased membrane “fluidity” of T lymphocytes from untreated patients with Hodgkin's disease
A Aleksijevic, G Cremel, C Mutet, C Giron, P Hubert, A Waksman, A Falkenrodt, F Oberling, S Mayer, JM Lang
Leukemia Research 1986
The Lectins
H Lis, N Sharon
The Lectins 1986
Characterization of multiple immune defects in human malignant lymphoma
RL Whisler, JL Murray, RW Roach, SP Balcerzak
Cancer 1984
New aspects of Hodgkin's disease: Staging for conservative management
RA Rostock
Critical Reviews in Oncology/Hematology 1984
Diseases of the Lymphatic System
DW Molander
1984
Infection among 210 patients with surgically staged Hodgkin's disease
DD Coker, DM Morris, JJ Coleman, SC Schimpff, PH Wiernik, EG Elias
The American Journal of Medicine 1983
Effect of mitogen concentration on glucocorticoid suppression of normal and cystic fibrosis lymphocyte activation
CW Distelhorst, BM Benutto, JM Corry
Cellular Immunology 1983
Basic and Clinical Tumor Immunology
RB Herberman
1983
Diseases associated with immunosuppression
ER Heise
Environmental Health Perspectives 1982
8 T cell disorders in haematological diseases
D Catovsky, DC Linch, PC Beverley
Clinics in Haematology 1982
Influence of non-specific immunologic factors on prognosis in advanced bronchogenic carcinoma
AM Liberati, JG Voelkel, EC Borden, AS Coates, DL Citrin, GT Bryan
Cancer Immunology, Immunotherapy 1982
Coexistence of a primary immunodeficiency disorder and hodgkin's disease: Evidence against a B-Lymphocyte origin for the reed-sternberg cell
AM Bobrove, O Onder, TJ Myers, FR Rickles, WT Pastuszak, RS Martin, DH Hild
Cancer 1981
Lymphoid subpopulations of peripheral blood and spleen in untreated Hodgkin's disease
MR Posner, EL Reinherz, J Breard, LM Nadler, DS Rosenthal, SF Schlossman
Cancer 1981
Immunobiology of primary intracranial tumors
WH Brooks, RB Latta, MS Mahaley, TL Roszman, L Dudka, C Skaggs
Journal of Neurosurgery 1981
Role of adherent suppressor cells in the depression of cell-mediated immunity in Hodgkin's disease and lung carcinoma
Y Thomas, R Huchet, D Grandjon
Annales de l'Institut Pasteur / Immunologie 1981
Influence of Splenectomy upon Immunologic Reactivity of Patients with Hodgkin'S Disease
J Rogan-Grgas, L Milas, E Hauptmann, P Nola, K Kolarić, Z Maričić, B Malenica
TUMORI 1981
Modern Trends in Human Leukemia IV
R Neth, RC Gallo, T Graf, K Mannweiler, K Winkler
1981
Autologous Mixed Lymphocyte Reaction in Patients with Hodgkin's Disease EVIDENCE FOR A T CELL DEFECT
EG Engleman, CJ Benike, RT Hoppe, HS Kaplan, FR Berberich
Journal of Clinical Investigation 1980
Spectrum of immunodeficiencies with Hodgkin's disease
JJ Twomey, AH Laughter, L Rice, R Ford
Journal of Clinical Investigation 1980
Correlation of prognostic factors and blood lymphocyte subtypes in non-Hodgkin's lymphoma
JL Murray, PE Hurtubise, DC Young, SP Balcerzak, AF Lobuglio
Cancer 1980
Hodgkin's disease: Unfolding concepts concerning its nature, management and prognosis
HS Kaplan
Cancer 1980
Animal model of human disease: leukemic lymphoma
RG Olsen, LE Mathes, LC Hebebrand, EA Hoover, WS Nichols
The American Journal of Pathology 1980
Demonstration of inhibitory factors affecting cell-mediated immunity in patients with Hodgkin's disease
MV Moghe, SH Advani, SG Gangal
European Journal of Cancer (1965) 1980
Mechanisms of Lymphocyte Activation THE ROLE OF SUPPRESSOR CELLS IN THE PROLIFERATIVE RESPONSES OF CHRONIC LYMPHATIC LEUKEMIA LYMPHOCYTES
GB Faguet
Journal of Clinical Investigation 1979
Cellular immunity in Hodgkin's disease
SH Advani, H D'silva, BP Gothoskar, KA Dinshaw, CN Nair, R Gopalkrishna, GV Talwalkar, PB Desai
Cancer 1979
Transient impairment of peripheral blood lymphocyte function during PUVA therapy
WL Morison, JA Parrish, KJ Bloch, JI Krugler
British Journal of Dermatology 1979
Inhibitors of T-cell mitogenesis: Effect of mitogen dose
JS Goodwin, RP Messner, RC Williams
Cellular Immunology 1979
The immunopathology of Hodgkin's disease
JC Long
Clinics in Haematology 1979
Relationship between T lymphocyte levels and lymphoproliferative responses to mitogens and alloantigens in lung and breast cancer patients
TR Jerrells, JH Dean, RB Herberman
International Journal of Cancer 1978
Incidental discovery at radical mastectomy of inapparent hodgkin's disease in long term survivors
GA Miller, CI Jarowski, M Coleman, ML Cibull, AF Posteraro, AE Weksler
Cancer 1978
The serum immunoglobulins in lymphoproliferative malignancies
G Rosset, JJ Farquet, A Cruchaud
European Journal of Cancer (1965) 1978
The Immunopathology of Lymphoreticular Neoplasms
JJ Twomey, RA Good
1978
Decreased lymphocyte reactivity to a suboptimal concentration of phytohemagglutinin in sjögren's syndrome
JP Michalski, C Mccombs
Arthritis & Rheumatism 1977
The long term effects of radiation on T and B lymphocytes in the peripheral blood after regional irradiation
RT Hoppe, ZY Fuks, S Strober, HS Kaplan
Cancer 1977
The relative proliferation index as a more sensitive parameter for evaluating lymphoproliferative responses of cancer patients to mitogens and alloantigens
JH Dean, R Connor, RB Herberman, J Silva, JL McCoy, RK Oldham
International Journal of Cancer 1977
Binding of Soluble Immune Complexes in Serum of Patients with Hodgkin's Disease to Tissue Cultures Derived from the Tumor
JC Long, CL Hall, CA Brown, C Stamatos, SA Weitzman, K Carey
New England Journal of Medicine 1977
Mechanisms of lymphocyte activation. Binding kinetics of phytohemagglutinin to human lymphocytes
GB Faguet
The Journal of biological chemistry 1977
Comparison of multiple in vivo and in vitro parameters in untreated patients with Hodgkin's disease
DC Case, JA Hansen, CW Young, B Dupont, CM Pinsky, RA Good
Cancer 1976
Interaction between Serum Factors and T Lymphocytes in Hodgkin's Disease: Use as a Diagnostic Test
Z Fuks, S Strober, HS Kaplan
New England Journal of Medicine 1976
The Reticuloendothelial System in Health and Disease
SM Reichard, MR Escobar, H Friedman
1976

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