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Citations to this article

The Central Nervous System as a Site of Action for the Coronary Vasoconstrictor Effect of Digoxin
Hasan Garan, … , Thomas W. Smith, Wm. John Powell Jr.
Hasan Garan, … , Thomas W. Smith, Wm. John Powell Jr.
Published December 1, 1974
Citation Information: J Clin Invest. 1974;54(6):1365-1372. https://doi.org/10.1172/JCI107883.
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Research Article

The Central Nervous System as a Site of Action for the Coronary Vasoconstrictor Effect of Digoxin

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Abstract

Digitalis is known to have a vasoconstrictor effect in the coronary circulation. Recent studies have demonstrated that the coronary vasoconstrictor effects of acetylstrophanthidin and digoxin are neurally mediated via alpha adrenergic fibers. In the present study, experiments were done in 20 dogs anesthetized with chloralose and urethane to study the central nervous system as a possible site of action for this vasoconstrictor effect of digoxin. After the intravenous administration of 1.0 mg digoxin, cerebrospinal fluid concentrations of digoxin rose to a peak of 2.3±0.4 (SEM) ng/ml at 15 min, temporally corresponding to the peak in coronary vascular resistance change of +20.0±2.5% of control in the paced canine heart. Submicrogram digoxin injections into the lateral cerebral ventricle produced a significant increase in coronary vascular resistance, the latter injection producing a peak increase in coronary vascular resistance of 12.4±1.2% of control. Cross-perfusion experiments, where the isolated head of the operative dog was perfused from a donor dog receiving digoxin, thus keeping digoxin levels in the remainder of the operative dog very low, showed a similar degree of coronary vasoconstriction. Thus, the central nervous system appears to be an important site of action for the early coronary vasoconstrictor effect of digoxin.

Authors

Hasan Garan, Thomas W. Smith, Wm. John Powell Jr.

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Total citations by year

Year: 2017 2010 2001 1996 1995 1992 1991 1990 1989 1988 1986 1985 1984 1983 1982 1981 1980 1979 1978 1977 1976 1975 1962 Total
Citations: 1 1 3 2 1 4 1 3 4 4 3 2 5 1 3 3 2 3 5 6 3 1 1 62
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (62)

Title and authors Publication Year
Acute Heart Failure
W Krüger
Acute Heart Failure 2017
The Gastrointestinal Circulation
PR Kvietys
Colloquium Series on Integrated Systems Physiology: From Molecule to Function 2010
Ouabain-Induced Coronary Vasoconstriction In Cats Is Not Neurally Mediated
BA Nair, YZ Murad, MJ Brody, DD Gutterman
Clinical and Experimental Pharmacology and Physiology 2001
Local and systemic effects of Na+/K+ ATPase inhibition
PH Joubert, M Grossmann
European Journal of Clinical Investigation 2001
Endocardial stimulation of efferent parasympathetic nerves to the atrioventricular node in humans: optimal stimulation sites and the effects of digoxin
K J Quan, G F Van Hare, L A Biblo, J A Mackall, M D Carlson
Journal of Interventional Cardiac Electrophysiology 2001
Digoxin reduces cardiac sympathetic activity in severe congestive heart failure
GE Newton, JH Tong, AM Schofield, AD Baines, JS Floras, JD Parker
Journal of the American College of Cardiology 1996
Effect of digitalis on conduction dysfunction in Pelizaeus-Merzbacher disease
A Nezu, S Kimura, H Osaka, T Kobayashi, N Ohtsuki
Journal of the Neurological Sciences 1996
Advances in Drug Research
CL Crespi
Advances in Drug Research 1995
Digitalis and heart failure: Does digitalis really produce beneficial effects through a positive inotropic action?
R Bolognesi, D Tsialtas, C Manca
Cardiovascular Drugs and Therapy 1992
The Heart in Hypertension
ED Frohlich, C Apstein, AV Chobanian, RB Devereux, HP Dustan, V Dzau, F Fauad-Tarazi, MJ Horan, M Marcus, B Massie, MA Pfeffer, RN Re, EJ Roccella, D Savage, C Shub
New England Journal of Medicine 1992
Acute hemodynamic effects of digoxin alone or in combination with other vasoactive agents in patients with congestive heart failure
JE Tisdale, M Gheorghiade
The American Journal of Cardiology 1992
The rational pharmacology of digoxin
PM Heerdt, ME Heerdt
Journal of Clinical Anesthesia 1992
Contrasting effects of digitalis and dobutamine on baroreflex sympathetic control in normal humans
HP Schobel, RM Oren, PJ Roach, AL Mark, DW Ferguson
Circulation 1991
Acute myocardial uptake of digoxin in humans: Correlation with hemodynamic and electrocardiographic effects
AC Powell, JD Horowitz, Y Hasin, ML Syrjanen, S Horomidis, WJ Louis
Journal of the American College of Cardiology 1990
RELATIONSHIP BETWEEN SYSTEMIC AND CORONARY VASCULAR RESPONSES TO DIGOXIN AND CONCURRENT DRUG THERAPY WITH VERAPAMIL/?-ADRENOCEPTOR ANTAGONISTS IN HUMANS
AC Powell, JD Horowitz, Y Hasin, WJ Louis
Clinical and Experimental Pharmacology and Physiology 1990
Effect of digitals on clinical symptoms and conduction variables in patients with multiple sclerosis
R Kaji, L Happel, AJ Sumner
Annals of Neurology 1990
Anaesthetic management for mitral valve replacement
P Chari, SK Malhotra, JS Gujral
Indian Journal of Thoracic and Cardiovascular Surgery 1989
Effect of digitalis on central demyelinative conduction block in vivo
R Kaji, AJ Sumner
Annals of Neurology 1989
Digitalis and Non-ACE Inhibitor Vasodilators in Heart Failure
K Chatterjee
Cardiology Clinics 1989
Sympathoinhibitory responses to digitalis glycosides in heart failure patients. Direct evidence from sympathetic neural recordings
DW Ferguson, WJ Berg, JS Sanders, PJ Roach, JS Kempf, MG Kienzle
Circulation 1989
Digitalis Glycosides: A Discussion of the Similarities and Differences in Actions and Existing Controversies
CM Lathers, LJ Lipka, H Klions
Journal of Basic and Clinical Physiology and Pharmacology 1988
EFFECTS OF THROMBOXANE SYNTHETASE INHIBITOR (UK 38,485) AND THROMBOXANE RECEPTOR ANTAGONIST (ICI 185,282) ON DIGOXIN-INDUCED ARRHYTHMIAS IN ANAESTHETIZED GUINEA-PIGS
I Kanzik, AT Demiryürek, H Zengil, N Abacio?lu, H Dörtlemez
Clinical and Experimental Pharmacology and Physiology 1988
Neurogenic histaminergic vasodilation in canine skeletal muscle: mediation by alpha 2-adrenoceptor stimulation
B Camazine, RP Shannon, JL Guerrero, RM Graham, WJ Powell
Circulation research 1988
Vasoconstriction induced by ouabain in the canine coronary artery: Contribution of adrenergic and nonadrenergic responses
JP Cooke, JT Shepherd, PM Vanhoutte
Cardiovascular Drugs and Therapy 1988
Possible contribution of digitalis-induced coronary constriction to toxicity
RD Tanz
American Heart Journal 1986
Drug Information Analysis Service
LL Hart, J Lopez
1986
Cardiac Glycosides 1785–1985
E Erdmann, K Greef, JC Skou
1986
Extracardiac and coronary vascular effects of digitalis
JC Longhurst, J Ross
Journal of the American College of Cardiology 1985
Digitalis: Neurally Mediated Arrhythmogenic and Coronary Vasoconstrictor Properties
JC Somberg
The Journal of Clinical Pharmacology 1985
Centrally-Induced Vasopressor Responses to Ouabain are Augmented in Spontaneously Hypertensive Rats
H Takahashi, I Iyoda, K Takeda, H Okajima, S Sasaki, M Yoshimura, M Nakagawa, H Ijichi
Clinical and Experimental Hypertension 1984
Part III Digitalis glycosides: Mechanisms and manifestations of toxicity
TW Smith, EM Antman, PL Friedman, CM Blatt, JD Marsh
Progress in Cardiovascular Diseases 1984
Part II Digitalis glycosides: Mechanisms and manifestations of toxicity
TW Smith, EM Antman, PL Friedman, CM Blatt, JD Marsh
Progress in Cardiovascular Diseases 1984
Part I Digitalis glycosides: Mechanisms and manifestations of toxicity
TW Smith, EM Antman, PL Friedman, CM Blatt, JD Marsh
Progress in Cardiovascular Diseases 1984
Koronarerkrankungen
H Roskamm, E Bassenge, HJ Becker, G Breithardt, P Bubenheimer, L Buchholz, CD Claussen, C Droste, H Eichstädt, WA Fach, R Felix, A Frey, L Görnandt, H Gohlke, C Gohlke-Bärwolf, M Gottwik, AR Gruentzig, P Harnasch, K Huesmann, T Ischinger, M Kaltenbach, D Kalusche, M Keck, D Köhler, W Langosch, G Lohmöller, H Lydtin, BV Mai, DG Mathey, W Morgenstern, E Nüssel, O Pachinger, J Petersen, R Poche, H Reindell, B Ritter, L Samek, W Schaper, R Scheidt, M Schmuziger, W Schneider, K Schnellbacher, KP Schüren, L Seipel, M Siebes, H Sochor, E Steinmann, M Stolte, P Stürzenhofecker, P Tollenaere, H Weidemann, A Weisswange, B Wille
1984
The Physiology and Pharmacology of the Microcirculation
RJ Traystman
The Physiology and Pharmacology of the Microcirculation 1983
Effect of ouabain on total vascular capacity in the dog
MR Goldman, SW Wolk, DL Rutlen, WJ Powell
Journal of Clinical Investigation 1982
Digitalis
KO Haustein
Pharmacology & Therapeutics 1982
The hypothalamus and digitalis cardiotoxicity
K Otsuka, H Kaba, H Saito, K Seto, T Yanaga
American Heart Journal 1982
Endogenous ligands and modulators of the digitalis receptors: Some candidates
RS Kim, FS LaBella
Pharmacology & Therapeutics 1981
Use of Digoxin Radioimmunoassay in Forensic Investigations of Tissue Distribution
P Sedgwick, VR Spiehler, RH Cravey
Clinical Toxicology 1981
Localization of the neurally mediated coronary vasoconstrictor properties of digitalis in the cat
JC Somberg, JE Kuhlman, TW Smith
Circulation research 1981
Digitalis cardiotoxicity revisited
CM Lathers, J Roberts
Life Sciences 1980
Digoxin-quinidine interaction
JE Doherty, KD Straub, ML Murphy, ND Soyza, JK Bissett, JJ Kane
The American Journal of Cardiology 1980
The role of the liver in the adrenergic regulation of blood flow from the splanchnic to the central circulation
DL Rutlen, EW Supple, WJ Powell
The Yale journal of biology and medicine 1979
Acetylstrophanthidin-induced reflex inhibition of canine renal sympathetic nerve activity mediated by cardiac receptors with vagal afferents
MD Thames
Circulation research 1979
Localization of the Neurally Mediated Arrhythmogenic Properties of Digitalis
JC Somberg, TW Smith
Science 1979
Effects of ouabain on coronary and systemic vascular resistance and myocardial oxygen consumption in patients without heart failure
H Demots, SH Rahimtoola, JH McAnulty, GA Porter
The American Journal of Cardiology 1978
Effect of digoxin on coronary blood flow and myocardial oxygen consumption in patients with chronic coronary artery disease
V Kötter, KP Schüren, R Schröder
The American Journal of Cardiology 1978
Cerebrospinal Fluid Digoxin Concentrations in Humans
JM Gayes, DJ Greenblatt, BL Lloyd, JS Harmatz, TW Smith
The Journal of Clinical Pharmacology 1978
Autonomic nervous system actions of cardiac glycosides
RA Gillis, CJ Helke, KJ Kellar, JA Quest
Biochemical Pharmacology 1978
Inotropic and toxic effects of a polar cardiac glycoside derivative in the dog
GH Mudge, BL Lloyd, DJ Greenblatt, TW Smith
Circulation research 1978
Neurogenic coronary vasoconstrictor effects of digitalis during acute global ischemia in dogs
KB Sagar, EC Hanson, WJ Powell
Journal of Clinical Investigation 1977
Accumulation of radioactive cardiac glycosides by various brain regions in relation to the dysrhythmogenic effect
S Dutta, BH Marks, EP Schoener
British Journal of Pharmacology 1977
ACCUMULATION OF RADIOACTIVE CARDIAC GLYCOSIDES BY VARIOUS BRAIN REGIONS IN RELATION TO THE DYSRHYTHMOGENIC EFFECT
S Dutta, B Marks, E Schoener
British Journal of Pharmacology 1977
The effect of ouabain on nutritional circulation and regional myocardial blood flow
GJ Gross, DC Warltier, HF Hardman, P Somani
American Heart Journal 1977
Effects of digitalis on resting and isometric exercise myocardial perfusion in patients with coronary artery disease and left ventricular dysfunction
R Vogel, D Kirch, M LeFree, J Frischknecht, P Steele
Circulation 1977
Konzentrationen von Digoxin und Beta-Methyldigoxin im Liquor und Plasma
G Bodem, U Boldt, H Ochs
Klinische Wochenschrift 1977
Reflex Increase in Coronary Vascular Resistance in Patients with Ischemic Heart Disease
GH Mudge, W Grossman, RM Mills, M Lesch, E Braunwald
New England Journal of Medicine 1976
Digitalis: Clinical implications of new facts about an old drug
DJ Greenblatt, TW Smith
Postgraduate Medicine 1976
Penetration of digoxin into cerebrospinal fluid
GD Schott, DW Holt, AM Hayler
Postgraduate medical journal 1976
Anesthesia for open-heart surgery: Its contribution to the care of the critically ill
MB Laver
Bulletin of the New York Academy of Medicine 1975
Cardiac Glycosides
DG Friend
New England Journal of Medicine 1962

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