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Research Article Free access | 10.1172/JCI107873

Effect of Acute and Chronic Calcium Administration on Plasma Renin

Theodore A. Kotchen, Kimball I. Mauli, Robert Luke, Douglas Rees, and Walter Flamenbaum

Department of Medicine, University of Kentucky School of Medicine, Lexington, Kentucky 40506

Department of Surgery, University of Kentucky School of Medicine, Lexington, Kentucky 40506

Department of Nephrology, Walter Reed Army Institute of Research, Washington, District of Columbia 20012

Find articles by Kotchen, T. in: PubMed | Google Scholar

Department of Medicine, University of Kentucky School of Medicine, Lexington, Kentucky 40506

Department of Surgery, University of Kentucky School of Medicine, Lexington, Kentucky 40506

Department of Nephrology, Walter Reed Army Institute of Research, Washington, District of Columbia 20012

Find articles by Mauli, K. in: PubMed | Google Scholar

Department of Medicine, University of Kentucky School of Medicine, Lexington, Kentucky 40506

Department of Surgery, University of Kentucky School of Medicine, Lexington, Kentucky 40506

Department of Nephrology, Walter Reed Army Institute of Research, Washington, District of Columbia 20012

Find articles by Luke, R. in: PubMed | Google Scholar

Department of Medicine, University of Kentucky School of Medicine, Lexington, Kentucky 40506

Department of Surgery, University of Kentucky School of Medicine, Lexington, Kentucky 40506

Department of Nephrology, Walter Reed Army Institute of Research, Washington, District of Columbia 20012

Find articles by Rees, D. in: PubMed | Google Scholar

Department of Medicine, University of Kentucky School of Medicine, Lexington, Kentucky 40506

Department of Surgery, University of Kentucky School of Medicine, Lexington, Kentucky 40506

Department of Nephrology, Walter Reed Army Institute of Research, Washington, District of Columbia 20012

Find articles by Flamenbaum, W. in: PubMed | Google Scholar

Published December 1, 1974 - More info

Published in Volume 54, Issue 6 on December 1, 1974
J Clin Invest. 1974;54(6):1279–1286. https://doi.org/10.1172/JCI107873.
© 1974 The American Society for Clinical Investigation
Published December 1, 1974 - Version history
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Abstract

To evaluate the effect of Ca++ on renin release, plasma renin activity (PRA) was measured after acute and chronic Ca++ administration. 1% CaCl2 was infused into one renal artery of 10 anesthetized dogs (0.3 mg/kg/min). The excreted fraction of filtered calcium (EFca++) and EFNa+ from the infused kidney were elevated (P < 0.04) during three successive 15-min infusion periods. Serum calcium concentration was significantly elevated (P < 0.001). Creatinine clearance, systemic arterial pressure, and renal blood flow did not change (P > 0.10). Compared to control (45 ng/ml/h±5.2 SE), renal venous PRA was suppressed (P < 0.0001) after infusion of Ca++ for 15, 30, and 45 min (20 ng/ml/h±4.6, 16 ng/ml/h±4.0, and 13 ng/ml/h±2.7, respectively). 15 and 30-min after infusion, PRA did not differ from control (P > 0.20). Chronic Ca++ loading was achieved in Sprague-Dawley rats by replacing drinking water with 1% CaCl2 for 17 days. At sacrifice, serum Ca++, Na+, and K+ of controls (n = 12) did not differ (P > 0.60) from Ca++-loaded rats (n = 12). Ca++ excretion (467 μeq/24 h±51) was elevated (P < 0.001) compared to controls (85 μeq/24 h±12). PRA (8.6 ng/ml/h±1.4) and renal renin content of Ca++-loaded rats did not differ from controls (P > 0.80). However, after 8 days of sodium deprivation, both PRA and renal renin content of calcium-loaded animals were significantly lower than the respective values in pair-fed controls (P < 0.005). During the period of sodium deprivation, calcium-drinking animals were in greater negative sodium balance than controls (P < 0.005). The data are consistent with the hypothesis that acute and chronic calcium administration inhibit renin secretion.

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