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Research Article Free access | 10.1172/JCI107820

Preferential Binding of βS Globin Chains Associated with Stroma in Sickle Cell Disorders

Arthur Bank, Gregory Mears, Robert Weiss, Joyce V. O'Donnell, and Clayton Natta

Department of Medicine, Columbia University, College of Physicians and Surgeons, New York 10032

Department of Human Genetics and Development, Columbia University, College of Physicians and Surgeons, New York 10032

Medical Services, Presbyterian Hospital, New York 10032

Sickle Cell Center, Harlem Hospital, New York 10030

Find articles by Bank, A. in: PubMed | Google Scholar

Department of Medicine, Columbia University, College of Physicians and Surgeons, New York 10032

Department of Human Genetics and Development, Columbia University, College of Physicians and Surgeons, New York 10032

Medical Services, Presbyterian Hospital, New York 10032

Sickle Cell Center, Harlem Hospital, New York 10030

Find articles by Mears, G. in: PubMed | Google Scholar

Department of Medicine, Columbia University, College of Physicians and Surgeons, New York 10032

Department of Human Genetics and Development, Columbia University, College of Physicians and Surgeons, New York 10032

Medical Services, Presbyterian Hospital, New York 10032

Sickle Cell Center, Harlem Hospital, New York 10030

Find articles by Weiss, R. in: PubMed | Google Scholar

Department of Medicine, Columbia University, College of Physicians and Surgeons, New York 10032

Department of Human Genetics and Development, Columbia University, College of Physicians and Surgeons, New York 10032

Medical Services, Presbyterian Hospital, New York 10032

Sickle Cell Center, Harlem Hospital, New York 10030

Find articles by O'Donnell, J. in: PubMed | Google Scholar

Department of Medicine, Columbia University, College of Physicians and Surgeons, New York 10032

Department of Human Genetics and Development, Columbia University, College of Physicians and Surgeons, New York 10032

Medical Services, Presbyterian Hospital, New York 10032

Sickle Cell Center, Harlem Hospital, New York 10030

Find articles by Natta, C. in: PubMed | Google Scholar

Published October 1, 1974 - More info

Published in Volume 54, Issue 4 on October 1, 1974
J Clin Invest. 1974;54(4):805–809. https://doi.org/10.1172/JCI107820.
© 1974 The American Society for Clinical Investigation
Published October 1, 1974 - Version history
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Abstract

Sickle cell anemia (SS) is associated with abnormalities of the red cell membrane and decreased red cell deformability. The present study assesses globin chain binding to stroma in SS, sickle cell trait (AS), and nonsickling (AA) cells. The results indicate that there is preferential binding of newly synthesized βS globin to red cell stroma in SS cells and preferential binding of βS to stroma compared to βA in AS cells. These studies show that βS globin binding to stroma accompanies the membrane abnormalities in SS and AS patients.

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