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Research Article Free access | 10.1172/JCI107820
Department of Medicine, Columbia University, College of Physicians and Surgeons, New York 10032
Department of Human Genetics and Development, Columbia University, College of Physicians and Surgeons, New York 10032
Medical Services, Presbyterian Hospital, New York 10032
Sickle Cell Center, Harlem Hospital, New York 10030
Find articles by Bank, A. in: JCI | PubMed | Google Scholar
Department of Medicine, Columbia University, College of Physicians and Surgeons, New York 10032
Department of Human Genetics and Development, Columbia University, College of Physicians and Surgeons, New York 10032
Medical Services, Presbyterian Hospital, New York 10032
Sickle Cell Center, Harlem Hospital, New York 10030
Find articles by Mears, G. in: JCI | PubMed | Google Scholar
Department of Medicine, Columbia University, College of Physicians and Surgeons, New York 10032
Department of Human Genetics and Development, Columbia University, College of Physicians and Surgeons, New York 10032
Medical Services, Presbyterian Hospital, New York 10032
Sickle Cell Center, Harlem Hospital, New York 10030
Find articles by Weiss, R. in: JCI | PubMed | Google Scholar
Department of Medicine, Columbia University, College of Physicians and Surgeons, New York 10032
Department of Human Genetics and Development, Columbia University, College of Physicians and Surgeons, New York 10032
Medical Services, Presbyterian Hospital, New York 10032
Sickle Cell Center, Harlem Hospital, New York 10030
Find articles by O'Donnell, J. in: JCI | PubMed | Google Scholar
Department of Medicine, Columbia University, College of Physicians and Surgeons, New York 10032
Department of Human Genetics and Development, Columbia University, College of Physicians and Surgeons, New York 10032
Medical Services, Presbyterian Hospital, New York 10032
Sickle Cell Center, Harlem Hospital, New York 10030
Find articles by Natta, C. in: JCI | PubMed | Google Scholar
Published October 1, 1974 - More info
Sickle cell anemia (SS) is associated with abnormalities of the red cell membrane and decreased red cell deformability. The present study assesses globin chain binding to stroma in SS, sickle cell trait (AS), and nonsickling (AA) cells. The results indicate that there is preferential binding of newly synthesized βS globin to red cell stroma in SS cells and preferential binding of βS to stroma compared to βA in AS cells. These studies show that βS globin binding to stroma accompanies the membrane abnormalities in SS and AS patients.