Resolution of Experimental Pulmonary Emboli with Heparin and Streptokinase in Different Dosage Regimens

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Abstract

Thrombolytic agents may be useful in acute pulmonary embolism, but their optimal dosage remains uncertain. We have examined the relative efficacy of heparin and different doses of streptokinase, either alone or in combination, in acute experimental pulmonary embolism. A standardized massive embolus of autologous blood clot incorporating canine [125I]-fibrinogen was given to 40 dogs; the degree of resolution after 24 h was quantitated by measuring the radioactivity in the lungs and was compared with detailed postmortem observations.

Authors

J. F. Cade, J. Hirsh, E. Regoeczi, M. Gent, M. R. Buchanan, D. M. Hynes