Advertisement

Concise Publication Free access | 10.1172/JCI107815

Evaluation of Leukocyte Chemotaxis In Vitro in Thermally Injured Patients

Glenn D. Warden, Arthur D. Mason Jr., and Basil A. Pruitt Jr.

United States Army Institute of Surgical Research, Brooke Army Medical Center, Fort Sam Houston, Texas 78234

Find articles by Warden, G. in: JCI | PubMed | Google Scholar

United States Army Institute of Surgical Research, Brooke Army Medical Center, Fort Sam Houston, Texas 78234

Find articles by Mason, A. in: JCI | PubMed | Google Scholar

United States Army Institute of Surgical Research, Brooke Army Medical Center, Fort Sam Houston, Texas 78234

Find articles by Pruitt, B. in: JCI | PubMed | Google Scholar

Published October 1, 1974 - More info

Published in Volume 54, Issue 4 on October 1, 1974
J Clin Invest. 1974;54(4):1001–1004. https://doi.org/10.1172/JCI107815.
© 1974 The American Society for Clinical Investigation
Published October 1, 1974 - Version history
View PDF
Abstract

Leukocyte chemotaxis in vitro was studied by a modification of the Boyden technic in 46 thermally injured patients. All patients demonstrated a decrease in leukocyte migration through a Nuclepore filter toward a standard casein-serum chemotactic agent. Leukocyte chemotaxis was inversely correlated with burn size during the first 72 h after injury. After 72 h, leukocyte chemotaxis directly correlated with clinical status and was highly predictive for ultimate mortality. Since mortality was largely due to infection, these findings suggest that suppression of leukocyte chemotaxis may explain the susceptibility to opportunistic infection in thermally injured patients.

Browse pages

Click on an image below to see the page. View PDF of the complete article

Version history
  • Version 1 (October 1, 1974): No description
Advertisement
Advertisement