Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
Top
  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal
  • Top
  • Abstract
  • Version history
  • Article usage
  • Citations to this article

Advertisement

Research Article Free access | 10.1172/JCI107796

Effect of Atropine on Gastrin and Gastric Acid Response to Peptone Meal

Stanislaw J. Konturek, Jerzy Biernat, Jan Oleksy, Jens F. Rehfeld, and Flemming Stadil

Institute of Physiology, Medical Academy, Kraków, Poland

District Hospital, Karków, Poland

Department of Clinical Chemistry, Bispebjerg Hospital, Copenhagen, Denmark

Find articles by Konturek, S. in: PubMed | Google Scholar

Institute of Physiology, Medical Academy, Kraków, Poland

District Hospital, Karków, Poland

Department of Clinical Chemistry, Bispebjerg Hospital, Copenhagen, Denmark

Find articles by Biernat, J. in: PubMed | Google Scholar

Institute of Physiology, Medical Academy, Kraków, Poland

District Hospital, Karków, Poland

Department of Clinical Chemistry, Bispebjerg Hospital, Copenhagen, Denmark

Find articles by Oleksy, J. in: PubMed | Google Scholar

Institute of Physiology, Medical Academy, Kraków, Poland

District Hospital, Karków, Poland

Department of Clinical Chemistry, Bispebjerg Hospital, Copenhagen, Denmark

Find articles by Rehfeld, J. in: PubMed | Google Scholar

Institute of Physiology, Medical Academy, Kraków, Poland

District Hospital, Karków, Poland

Department of Clinical Chemistry, Bispebjerg Hospital, Copenhagen, Denmark

Find articles by Stadil, F. in: PubMed | Google Scholar

Published September 1, 1974 - More info

Published in Volume 54, Issue 3 on September 1, 1974
J Clin Invest. 1974;54(3):593–597. https://doi.org/10.1172/JCI107796.
© 1974 The American Society for Clinical Investigation
Published September 1, 1974 - Version history
View PDF
Abstract

The action of intravenous atropine on meal-and pentagastrin-induced gastric acid secretion was studied in six duodenal ulcer patients.

A test meal of 10% peptone solution adjusted to pH 5.0 was maintained in the stomach at at distention presure of 15 cm H2O, and a modification of the intragastric titration method of Fordtran and Walsh was used to measure gastric acid output by monitoring the rate at which a solution of 0.5 M sodium bicarbonate had to be added to keep the pH of the gastric content constant at the initial (pH 5.0) value. Serum gastrin concentrations were measured simultaneously by radioimmunoassy. The dose of 25 μg/kg-h atropine inhibited meal-induced acid secretion by about 70% and that evoked by pentagastrin by about 30%. The serum gastrin response to the test meal was not significantly altered by atropine.

We conclude that atropine is a very strong inhibitor of meal-induced gastric acid secretion and does not significantly change serum gastrin response to feeding in duodenal ulcer patients when postprandial gastric acidity (pH 5.0) and intragastric pressure (15 cm H2O) are kept constant.

Browse pages

Click on an image below to see the page. View PDF of the complete article

icon of scanned page 593
page 593
icon of scanned page 594
page 594
icon of scanned page 595
page 595
icon of scanned page 596
page 596
icon of scanned page 597
page 597
Version history
  • Version 1 (September 1, 1974): No description

Article tools

  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal

Metrics

  • Article usage
  • Citations to this article

Go to

  • Top
  • Abstract
  • Version history
Advertisement
Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts