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Usage Information

Biological Defense Mechanisms THE EFFECT OF BACTERIA AND SERUM ON SUPEROXIDE PRODUCTION BY GRANULOCYTES
John T. Curnutte, Bernard M. Babior
John T. Curnutte, Bernard M. Babior
Published June 1, 1974
Citation Information: J Clin Invest. 1974;53(6):1662-1672. https://doi.org/10.1172/JCI107717.
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Research Article

Biological Defense Mechanisms THE EFFECT OF BACTERIA AND SERUM ON SUPEROXIDE PRODUCTION BY GRANULOCYTES

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Abstract

We previously reported that granulocytes are able to produce superoxide (O2-), a highly reactive compound formed by the one-electron reduction of oxygen. The demonstration of O2- production was based on the observation that the reduction of extra-cellular cytochrome c by granulocytes was greatly diminished by superoxide dismutase, an enzyme catalyzing the conversion of O2- to hydrogen peroxide and oxygen. In the present report, studies concerning the effect of bacteria and serum on O2--dependent cytochrome c reduction by granulocytes are described.

Authors

John T. Curnutte, Bernard M. Babior

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Usage data is cumulative from May 2024 through May 2025.

Usage JCI PMC
Text version 209 1
PDF 65 11
Figure 0 1
Scanned page 417 1
Citation downloads 69 0
Totals 760 14
Total Views 774
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