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Concise Publication Free access | 10.1172/JCI107699
1Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27514
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1Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27514
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1Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27514
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Published May 1, 1974 - More info
Complete ureteral ligation of 24-h duration significantly reduced stop-flow and estimated glomerular capillary pressures in nephrons accessible to micropuncture in obstructed kidneys. In kidneys without ureteral obstruction, a similar response occurred in single tubules blocked for 24 h without affecting nearby unblocked tubules. Thus, the response to tubular obstruction occurs on an individual nephron basis and results from constriction of individual afferent arterioles. The mechanism leading to the response is unknown, but a feedback mechanism operating through the juxtaglomerular apparatus of individual nephrons is an attractive possibility.
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