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Concise Publication Free access | 10.1172/JCI107699

Nephron Stop-Flow Pressure Response to Obstruction for 24 Hours in the Rat Kidney

William J. Arendshorst, William F. Finn, and Carl W. Gottschalk

1Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27514

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1Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27514

Find articles by Finn, W. in: PubMed | Google Scholar

1Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27514

Find articles by Gottschalk, C. in: PubMed | Google Scholar

Published May 1, 1974 - More info

Published in Volume 53, Issue 5 on May 1, 1974
J Clin Invest. 1974;53(5):1497–1500. https://doi.org/10.1172/JCI107699.
© 1974 The American Society for Clinical Investigation
Published May 1, 1974 - Version history
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Abstract

Complete ureteral ligation of 24-h duration significantly reduced stop-flow and estimated glomerular capillary pressures in nephrons accessible to micropuncture in obstructed kidneys. In kidneys without ureteral obstruction, a similar response occurred in single tubules blocked for 24 h without affecting nearby unblocked tubules. Thus, the response to tubular obstruction occurs on an individual nephron basis and results from constriction of individual afferent arterioles. The mechanism leading to the response is unknown, but a feedback mechanism operating through the juxtaglomerular apparatus of individual nephrons is an attractive possibility.

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