Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Attenuated Vasodilator Responses to K+ in Essential Hypertensive Men
Henry W. Overbeck, … , Motilal B. Pamnani, Tümay Sözen
Henry W. Overbeck, … , Motilal B. Pamnani, Tümay Sözen
Published March 1, 1974
Citation Information: J Clin Invest. 1974;53(3):678-686. https://doi.org/10.1172/JCI107605.
View: Text | PDF
Research Article

Attenuated Vasodilator Responses to K+ in Essential Hypertensive Men

  • Text
  • PDF
Abstract

To study limb vascular responses to K+ in man, paired intrabrachial arterial infusions of isosmolar NaCl (control) and isosmolar KCl (0.077, 0.154, and 0.307 meq K+/min) in isosmolar NaCl were made in 20 normotensive men and 20 men with essential hypertension of mild to moderate severity. Limb blood pressures were monitored, limb blood flow was measured by indicator-dilution, and limb vascular resistance was calculated as mm Hg/ml flow/min/100 cm3 limb volume. Measured concentrations of K+ in limb venous plasma during infusion of 0.307 meq K+/min ranged from 4.8 to 9.0 meq/liter. Changes in limb venous hematocrit, sodium, calcium, magnesium, and osmolality were similar during control and KCl infusions. The infusions did not significantly change systemic blood K+ concentration or blood pressures. Compared to NaCl, KCl decreased limb resistance (P < 0.05) in both normotensives and hypertensives, in a dose-related manner. Resting limb vascular resistances (IR) in hypertensives were greater (P < 0.05) than those in normotensives. Despite a positive correlation (P < 0.05) between IR and magnitude of response to K+, responses in hypertensives to K+ were not greater than those in normotensives. Further, analysis of covariance indicated that responses to 0.307 meq K+/min in hypertensives as a group were, in fact, less (P = 0.02) than those in normotensives. These results indicate that the vasodilator response to K+ may be attenuated in a significant proportion of essential hypertensive men, as it is in renal hypertensive animals. These abnormal responses to K+ in hypertensives may indicate an underlying defect in vascular K+ metabolism.

Authors

Henry W. Overbeck, Randall S. Derifield, Motilal B. Pamnani, Tümay Sözen

×

Total citations by year

Year: 2022 2021 2020 2018 2014 2011 2002 2001 1997 1995 1994 1993 1992 1990 1988 1987 1986 1985 1984 1983 1982 1981 1980 1979 1978 1976 1975 1974 Total
Citations: 2 1 1 1 1 108 1 1 1 1 3 2 2 3 3 5 2 2 1 6 8 6 1 1 1 1 2 1 168
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (168)

Title and authors Publication Year
State of Knowledge on Molecular Adaptations to Exercise in Humans: Historical Perspectives and Future Directions
Lavin KM, Coen PM, Baptista LC, Bell MB, Drummer D, Harper SA, Lixandrão ME, McAdam JS, O\u2019Bryan SM, Ramos S, Roberts LM, Vega RB, Goodpaster BH, Bamman MM, Buford TW
Comprehensive Physiology 2022
Physiological Systems in Promoting Frailty
Perazza LR, Brown-Borg HM, Thompson LV
Comprehensive Physiology 2022
Multi-omic Approaches to Identify Genetic Factors in Metabolic Syndrome
Clark KC, Kwitek AE
Comprehensive Physiology 2021
Glucagon-like Peptide-1: Actions and Influence on Pancreatic Hormone Function
Davis EM, Sandoval DA
Comprehensive Physiology 2020
Endothelium-Dependent Hyperpolarization (EDH) in Hypertension: The Role of Endothelial Ion Channels.
Goto K, Ohtsubo T, Kitazono T
International journal of molecular sciences 2018
Comprehensive Physiology
SN Cheuvront, RW Kenefick
Comprehensive Physiology 2014
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Eicosapentaenoic Acid Improves Endothelial Function in Hypertriglyceridemic Subjects Despite Increased Lipid Oxidizability
T Okumura, Y Fujioka, S Morimoto, S Tsuboi, M Masai, T Tsujino, M Ohyanagi, T Iwasaki
The American Journal of the Medical Sciences 2002
Characterization of endothelium-derived hyperpolarizing factor in the human forearm microcirculation
JP Halcox, S Narayanan, L Cramer-Joyce, R Mincemoyer, AA Quyyumi
American journal of physiology. Heart and circulatory physiology 2001
Hypokalemia and Potassium Excretion in Stroke Patients
SE Gariballa, TG Robinson, MD Fotherby
Journal of the American Geriatrics Society 1997
Measuring Forearm Blood Flow and Interpreting the Responses to Drugs and Mediators
N Benjamin, A Calver, J Collier, B Robinson, P Vallance, D Webb
Hypertension 1995
Digoxin-like inhibitors of active sodium transport and blood pressure: The current status
RG Woolfson, L Poston, HE de Wardener
Kidney International 1994
Insulin blunts sympathetic vasoconstriction through the alpha 2-adrenergic pathway in humans
G Lembo, G Iaccarino, V Rendina, M Volpe, B Trimarco
Hypertension 1994
Ion Channels and Ion Pumps
PP Foà, MF Walsh
1994
The role of diet in the genesis and treatment of hypertension
PP Stein, HR Black
Medical Clinics of North America 1993
Salt loads attenuate potassium-induced vasodilation of forearm vasculature in humans
T Fujita, Y Ito
Hypertension 1993
Contractions induced by potassium-free solution and potassium relaxation in vascular smooth muscle of hypertensive and normotensive rats
P Arvola, I Pörsti, P Vuorinen, A Pekki, H Vapaatalo
British Journal of Pharmacology 1992
High calcium diet augments vascular potassium relaxation in hypertensive rats
I Pörsti, P Arvola, H Wuorela, H Vapaatalo
Hypertension 1992
Attenuated vasodilator responses to Mg2+ in young patients with borderline hypertension
T Fujita, Y Ito, K Ando, H Noda, E Ogata
Circulation 1990
Impaired potassium-induced dilation in hypertensive rat cerebral arteries does not reflect altered Na+,K(+)-ATPase dilation
JG McCarron, W Halpern
Circulation research 1990
Efficacy of potassium and magnesium in essential hypertension: a double-blind, placebo controlled, crossover study
PS Patki, J Singh, SV Gokhale, PM Bulakh, DS Shrotri, B Patwardhan
BMJ : British Medical Journal 1990
The Anti-Hypertensive Effect of Potassium Loading in Experimental Hypertension: A Comparison of Sheep with Other Species
EH Mills, JP Coghlan, DA Denton, CD Spence, JA Whitworth, BA Scoggins
Clinical and Experimental Hypertension 1988
Effect of indapamide on phosphate metabolism and vascular reactivity
GE Plante, MC Lafreniere, PT Tam, P Sirois
The American Journal of Medicine 1988
Purification and Characterization of Specific Endogenous Ouabainlike Substance from Bovine Adrenal
T Inagami, M Tamura
The American Journal of the Medical Sciences 1988
Decreased Na+K+ATPase Activity in the Aortic Endothelium and Smooth Muscle of the Spontaneously Hypertensive Rats
S Manjeet, MK Sim
Clinical and Experimental Hypertension 1987
Cations in essential hypertension
MH Maxwell, AU Waks
The American Journal of Cardiology 1987
Reduced electrogenic sodium-potassium pump in arterioles during renovascular hypertension
JH Lombard, WL Joyner, WJ Stekiel
Hypertension 1987
The vascular Na+-K+ pump in experimental hypertension
HW Overbeck
Hypertension 1987
Arterial and Venous Systems in Essential Hypertension
ME Safar, GM London, AC Simon, YA Weiss
1987
Hypertension and diabetes in obesity: A review and new ideas on the contributing role of ions
RS El-Mallakh
Medical Hypotheses 1986
Vascular responses to ouabain and norepinephrine in low and normal renin hypertension
R Pedrinelli, S Taddei, L Graziadei, A Salvetti
Hypertension 1986
Hemodynamic, renal, and hormonal responses to changes in dietary potassium in normotensive and hypertensive man: Long-term antihypertensive effect of potassium supplementation in essential hypertension
A Overlack, KO Stumpe, B Moch, A Ollig, R Kleinmann, HM Müller, R Kolloch, F Krück
Klinische Wochenschrift 1985
Hemodynamic, renal, and hormonal responses to changes in dietary potassium in normotensive and hypertensive man: Long-term antihypertensive effect of potassium supplementation in essential hypertension
A Overlack, KO Stumpe, B Moch, A Ollig, R Kleinmann, , R Kolloch, F Krück
Klinische Wochenschrift 1985
Hemodynamic and endocrine changes associated with potassium supplementation in sodium-loaded hypertensives
T Fujita, K Ando
Hypertension 1984
Natriuretic and antihypertensive effects of potassium in DOCA-salt hypertensive rats
T Fujita, Y Sato
Kidney International 1983
Na+-K+-ATPase in rat vascular smooth muscle cell grown in vitro
A Aviv, H Higashino, D Hensten, JW Bauman, BW Lubit, BM Searle
American journal of physiology. Cell physiology 1983
Role of dietary potassium in the treatment of hypertension
J Treasure, D Ploth
Hypertension 1983
Effect of anteroventral third ventricle lesions on vascular sodium-pump activity in two-kidney Goldblatt hypertension
E Songu-Mize, SL Bealer, RW Caldwell
Hypertension 1983
Decrease in Na+,K+-ATPase activity and [3H]ouabain binding sites in sarcolemma prepared from hearts of spontaneously hypertensive rats
SW Lee, A Schwartz, RJ Adams, Y Yamori, K Whitmer, LK Lane, ET Wallick
Hypertension 1983
Topics in Pathophysiology of Hypertension
H Villarreal, MP Sambhi
1983
MODERATE POTASSIUM SUPPLEMENTATION IN ESSENTIAL HYPERTENSION
GA Macgregor, ND Markandu, SJ Smith, RA Banks, GA Sagnella
The Lancet 1982
THE NATRIURETIC HORMONE AND ESSENTIAL HYPERTENSION
HE Wardener, GA Macgregor
The Lancet 1982
Hemodynamic effects of alterations in potassium
MS Paller, SL Linas
Hypertension 1982
Sodium pump activity in arteries of rats with Goldblatt hypertension
HW Overbeck, DE Grissette
Hypertension 1982
Function of the sodium pump in arterial smooth muscle in experimental hypertension: role of pressure
HW Overbeck, DR Bell, DE Grissette, TA Brock
Hypertension 1982
Effect of AV3V lesions on development of DOCA-salt hypertension and vascular Na+-pump activity
E Songu-Mize, SL Bealer, RW Caldwell
Hypertension 1982
Potassium relaxation of vascular smooth muscle from DOCA hypertensive pigs
RC Webb
Hypertension 1982
Increased circulating levels of an endogenous digoxin-like factor in hypertensive monkeys
KA Gruber, LL Rudel, BC Bullock
Hypertension 1982
Sodium excess or potassium lack as a cause of hypertension: a discussion paper
CJ Bulpitt
Journal of the Royal Society of Medicine 1981
Recent advances in the pathogenesis of hypertension: Consideration of structural, functional, and metabolic vascular abnormalities resulting in elevated arterial resistance
RC Webb, DF Bohr
American Heart Journal 1981
The natriuretic hormone and hypertension
HE Wardener, GA MacGregor
Journal of Chronic Diseases 1981
Effect of potassium chloride on the blood pressure in two-kidney, one clip Goldblatt hypertensive rats
H Suzuki, K Kondo, T Saruta
Hypertension 1981
Sodium pump activity in arteries of Dahl salt-sensitive rats
HW Overbeck, DD Ku, JP Rapp
Hypertension 1981
Sodium and potassium in essential hypertension
AF Lever, C Beretta-Piccoli, JJ Brown, DL Davies, R Fraser, JI Robertson
BMJ : British Medical Journal 1981
NMR observation of altered sodium interaction with human erythrocyte membranes of essential hypertensives
DW Urry, TL Trapane, SK Andrews, MM Long, HW Overbeck, S Oparil
Biochemical and Biophysical Research Communications 1980
Commentary. The sodium pump in cardiovascular muscle in hypertension: whose hypothesis?
H W Overbeck
Clinical and Experimental Hypertension 1979
The Sodium-Potassium Pump in Volume Expanded Hypertension
F Haddy, M Pamnani, D Clough
Clinical and Experimental Hypertension 1978
The role of humoral agents in volume expanded hypertension
FJ Haddy, HW Overbeck
Life Sciences 1976
Cyclic nucleotides in disease; On the biochemical etiology of hypertension
MS Amer
Life Sciences 1975
Potassium and blood vessels
FJ Haddy
Life Sciences 1975
A proposed cybernetic system for sodium and potassium homeostasis: Coordination of aldosterone and intrarenal physical factors
JE Sealey, JH Laragh
Kidney International 1974

← Previous 1 2 … 5 6 7 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts