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Research Article Free access | 10.1172/JCI107554

Hemoglobin San Diego (β109 (G11) Val→Met) CRYSTAL STRUCTURE OF THE DEOXY FORM

N. Leigh Anderson

Medical Research Council (MRC) Laboratory of Molecular Biology, Cambridge, England

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Published January 1, 1974 - More info

Published in Volume 53, Issue 1 on January 1, 1974
J Clin Invest. 1974;53(1):329–333. https://doi.org/10.1172/JCI107554.
© 1974 The American Society for Clinical Investigation
Published January 1, 1974 - Version history
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Abstract

The three-dimensional structure of deoxyhemoglobin San Diego has been solved to 3.5 Å resolution using mixed crystals of the variant hemoglobin and hemoglobin A. The site of the amino acid replacement can be clearly located in the difference electron density map and is consistent with the chemical result (β109 Val→Met) discussed in the preceding paper. The abnormally high oxygen affinity and impaired cooperativity appear to result from perturbations of the α1β1-subunit interface.

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