Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

The Fibrinolytic Pathway of Human Plasma II. THE GENERATION OF CHEMOTACTIC ACTIVITY BY ACTIVATION OF PLASMINOGEN PROACTIVATOR
Allen P. Kaplan, … , Edward J. Goetzl, K. Frank Austen
Allen P. Kaplan, … , Edward J. Goetzl, K. Frank Austen
Published October 1, 1973
Citation Information: J Clin Invest. 1973;52(10):2591-2595. https://doi.org/10.1172/JCI107451.
View: Text | PDF
Research Article

The Fibrinolytic Pathway of Human Plasma II. THE GENERATION OF CHEMOTACTIC ACTIVITY BY ACTIVATION OF PLASMINOGEN PROACTIVATOR

  • Text
  • PDF
Abstract

The conversion of plasminogen proactivator to plasminogen activator by Hageman factor fragments results in the generation of chemotactic activity for human neutrophils. This chemotactic activity can be distinguished from that generated by Hageman factor activation of prekallikrein and is demonstrable in plasma that is genetically deficient in prekallikrein (Fletcher factor deficiency). Both the plasminogen-activating activity and chemotactic activity produced by the interaction of Hageman factor fragments and plasminogen proactivator to yield plasminogen activator were inhibited by diisopropyl fluorophosphate (DFP) indicating an essential role for the enzymatic site in both these activities. The finding that the plasminogen proactivator tolerated a dose of DFP, which completely inactivated the plasminogen activator, reveals that the active site is protected in the precursor protein.

Authors

Allen P. Kaplan, Edward J. Goetzl, K. Frank Austen

×

Total citations by year

Year: 2012 2011 2004 1995 1994 1992 1991 1990 1988 1986 1985 1984 1983 1982 1981 1980 1979 1978 1977 1976 1975 1974 1968 Total
Citations: 1 2 1 1 2 1 2 2 1 2 1 1 1 3 1 5 4 3 4 8 6 3 1 56
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (56)

Title and authors Publication Year
Methods in Enzymology
JD Stone, AS Chervin, DH Aggen, DM Kranz
Protein Engineering for Therapeutics Part B 2012
Advances in Immunology
E Pinaud, M Marquet, R Fiancette, S Péron, C Vincent-Fabert, Y Denizot, M Cogné
Advances in Immunology Volume 110 2011
Advances in Cancer Research
M Lemaire, S Deleu, ED Bruyne, EV Valckenborgh, E Menu, K Vanderkerken
Advances in Cancer Research Volume 110 2011
Reviews of Physiology, Biochemistry and Pharmacology
B Gebert, W Fisher, R Haas
Reviews of Physiology, Biochemistry and Pharmacology 2004
Phagocytosis
EJ Brown
BioEssays 1995
Xenobiotics and Inflammation
PF Piguet
Xenobiotics and Inflammation 1994
In Vitro Toxicity Indicators
Y Park, TY Aw, DP Jones
In Vitro Toxicity Indicators 1994
Biochemistry of Inflammation
JT Whicher, SW Evans
1992
Platelet activating factors (AGEPC) from epidermal secretions of the Arabian Gulf catfish, Arius bilineatus, which stimulate wound healing
B Summers, JM Al-Hassan, M Thomson, A Chun, RS Criddle
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1991
Deep Venous Thrombosis and Pulmonary Embolism in Pregnancy
SE Rutherford, JP Phelan
Obstetrics and Gynecology Clinics of North America 1991
Neutrophil Function And Oral Disease
TE van Dyke, GA Hoop
Critical Reviews in Oral Biology & Medicine 1990
Peptide Growth Factors and Their Receptors II
MB Sporn, AB Roberts
1990
The Role of White Blood Cells in Post-Mortem Wounds
TT Ali
Medicine Science and the Law 1988
Potential role of activated macrophages in acetaminophen hepatotoxicity
DL Laskin, AM Pilaro, S Ji
Toxicology and Applied Pharmacology 1986
The role of complement in experimental silicosis
AH Callis, PG Sohnle, GS Mandel, NS Mandel
Environmental Research 1986
Neutrophil function and oral disease
TE Dyke, MJ Levine, RJ Genco
Journal of Oral Pathology and Medicine 1985
Biologically active complement (C5)-derived peptides and their relevance to disease
HD Perez
Critical Reviews in Oncology/Hematology 1984
Relationships among the complement, kinin, coagulation, and fibrinolytic systems
JS Sundsmo, DS Fair
Springer Seminars in Immunopathology 1983
An alkaline proteinase which has inflammatory activity isolated from guinea pig lymphoid cells
T Kambara, T Kawagoe, T Nakamura
Biochimica et Biophysica Acta (BBA) - General Subjects 1982
Unusual intracytoplasmic immunoglobulin inclusions in chronic lymphocytic leukaemia
P Guglielmi, JL Preud'homme, MF Gourdin, F Reyes, MT Daniel
British Journal of Haematology 1982
Dextran-Induced Lowering of Plasminogen Proactivator and Functionally Active High Molecular Weight Kininogen in the Rat
J Berstad, K Briseid
Acta Pharmacologica et Toxicologica 1982
Platelet factor 4 is chemotactic for neutrophils and monocytes
TF Deuel, R M, D Chang, GL Griffin, RL Heinrikson, ET Kaiser
Proceedings of the National Academy of Sciences 1981
Human Alveolar Macrophage-derived Chemotactic Factor for Neutrophils STIMULI AND PARTIAL CHARACTERIZATION
GW Hunninghake, JE Gadek, HM Fales, RG Crystal
Journal of Clinical Investigation 1980
The Influence of Serum on Random Migration and Chemotaxis of Polymorphonuclear Leucocytes: Methodological Evaluation using Sera from Infection-prone Patients and Normals
L Hakansson, P Venge
Scandinavian Journal of Immunology 1980
Effects of human complement component 1 inactivator on neutrophil chemotaxis and chemotactic deactivation
RA Patrick, JC Hollers, DY Liu, BH Giese, CW Smith
Infection and immunity 1980
Host defense against infection — Part 2
RJ Howard
Current Problems in Surgery 1980
Human plasma prekallikrein. Studies of its activation by activated factor XII and of its inactivation by diisopropyl phosphofluoridate
BN Bouma, LA Miles, G Beretta, JH Griffin
Biochemistry 1980
Neutrophil function and host resistance
B Zakhireh, LH Block, RK Root
Infection 1979
Transcutaneous Leukocyte Migration in Vivo: Cellular Kinetics, Platelet and C5a Dependent Activity
BS Goldberg, WL Weston, PF Kohler, MB Harris, JR Humbert
Journal of Investigative Dermatology 1979
Cellular, Molecular, and Clinical Aspects of Allergic Disorders
S Gupta, RA Good
1979
Purification and characterization of human vascular plasminogen activator derived from blood vessel perfusates
BR Binder, J Spragg, KF Austen
The Journal of biological chemistry 1979
Chemotaxis by polymorphonuclear leukocytes
SH Zigmond
The Journal of Cell Biology 1978
Effect of prostaglandin E2 on two different preparations of cyclic 3′,5′-nucleotide phosphodiesterase
D Egg, G Gantner
Pharmacological Research Communications 1978
Phagocytosis: A Review
MN Walters, JM Papadimitriou, WG Spector
Critical Reviews in Toxicology 1978
Acute inflammation. A review
GB Ryan, G Majno
The American Journal of Pathology 1977
Coagulopathies
JH Lewis, JA Spero, U Hasiba
Disease-a-Month 1977
Recent Developments in the Pharmacology of Inflammatory Mediators
IL Bonta
1977
Biological Amplification Systems in Immunology
NK Day, RA Good
1977
ACTIVATION AND CONTROL MECHANISMS OF THE PLASMA KININ-FORMING SYSTEM AND ITS RELATIONSHIP TO COAGULATION AND FIBRINOLYSIS
AP Kaplan
Journal of Investigative Dermatology 1976
Membrane Receptors on Neutrophils
PM Henson
Immunological Investigations 1976
Modulation of human eosinophil polymorphonuclear leukocyte migration and function
EJ Goetzl
The American Journal of Pathology 1976
Serum chemotactic inhibitory activity: heat activation of chemotactic inhibition
DE Epps, RC Williams
Infection and immunity 1976
A phagocytosis-enhancing factor in human plasma
I Gigli, BU Wintroub, EJ Goetzl
Immunology 1976
Prekallikrein and plasminogen proactivator: Absence of plasminogen proactivator in fletcher factor deficient plasma
AM Venneröd, K Laake
Thrombosis Research 1976
Clinical and physiologic studies of two siblings with prekallikrein (Fletcher factor) deficiency
WE Hathaway, KD Wuepper, WL Weston, JR Humbert, RP Rivers, E Genton, CS August, RR Montgomery, MF Mass
The American Journal of Medicine 1976
Kinins: Pharmacodynamics and Biological Roles
F Sicuteri, N Back, GL Haberland
1976
Interaction of leukocyte chemotactic factors with the cell surface. I. Chemotactic factor-induced changes in human granulocyte surface charge
JI Gallin, JR Durocher, AP Kaplan
Journal of Clinical Investigation 1975
Activation and control mechanisms of Hageman factor-dependent pathways of coagulation, fibrinolysis, and kinin generation and their contribution to the inflammatory response
AP Kaplan, KF Austen
Journal of Allergy and Clinical Immunology 1975
LASMA AND CELL-DERIVED INHIBITORS OF HUMAN NEUTROPHIL CHEMOTAXIS
EJ Goetzl
Annals of the New York Academy of Sciences 1975
ABNORMALITIES OF LEUKOCYTE CHEMOTAXIS IN HUMAN DISEASE
R Snyderman, MC Pike, LC Altman
Annals of the New York Academy of Sciences 1975
CHEMOTAXIS AND HAEMOSTASIS
AB Kay, AP Kaplan
British Journal of Haematology 1975
Leucocyte Chemotaxis: Physiological Considerations and Abnormalities
JI Gallin, SM Wolff
Clinics in Haematology 1975
Leukotaxis and leukotactic disorders. A review
PA Ward
The American Journal of Pathology 1974
The hageman factor dependent pathways of human plasma
AP Kaplan
Microvascular Research 1974
Mediators of Inflammation
G Weissmann
Mediators of Inflammation 1974
Immunopharmacology
BB Levine
Immunopharmacology 1968

← Previous 1 2 3 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts