The conversion of plasminogen proactivator to plasminogen activator by Hageman factor fragments results in the generation of chemotactic activity for human neutrophils. This chemotactic activity can be distinguished from that generated by Hageman factor activation of prekallikrein and is demonstrable in plasma that is genetically deficient in prekallikrein (Fletcher factor deficiency). Both the plasminogen-activating activity and chemotactic activity produced by the interaction of Hageman factor fragments and plasminogen proactivator to yield plasminogen activator were inhibited by diisopropyl fluorophosphate (DFP) indicating an essential role for the enzymatic site in both these activities. The finding that the plasminogen proactivator tolerated a dose of DFP, which completely inactivated the plasminogen activator, reveals that the active site is protected in the precursor protein.
Allen P. Kaplan, Edward J. Goetzl, K. Frank Austen
Title and authors | Publication | Year |
---|---|---|
Methods in Enzymology
JD Stone, AS Chervin, DH Aggen, DM Kranz |
Protein Engineering for Therapeutics Part B | 2012 |
Advances in Immunology
E Pinaud, M Marquet, R Fiancette, S Péron, C Vincent-Fabert, Y Denizot, M Cogné |
Advances in Immunology Volume 110 | 2011 |
Advances in Cancer Research
M Lemaire, S Deleu, ED Bruyne, EV Valckenborgh, E Menu, K Vanderkerken |
Advances in Cancer Research Volume 110 | 2011 |
Reviews of Physiology, Biochemistry and Pharmacology
B Gebert, W Fisher, R Haas |
Reviews of Physiology, Biochemistry and Pharmacology | 2004 |
Phagocytosis
EJ Brown |
BioEssays | 1995 |
Xenobiotics and Inflammation
PF Piguet |
Xenobiotics and Inflammation | 1994 |
In Vitro Toxicity Indicators
Y Park, TY Aw, DP Jones |
In Vitro Toxicity Indicators | 1994 |
Biochemistry of Inflammation
JT Whicher, SW Evans |
1992 | |
Platelet activating factors (AGEPC) from epidermal secretions of the Arabian Gulf catfish, Arius bilineatus, which stimulate wound healing
B Summers, JM Al-Hassan, M Thomson, A Chun, RS Criddle |
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 1991 |
Deep Venous Thrombosis and Pulmonary Embolism in Pregnancy
SE Rutherford, JP Phelan |
Obstetrics and Gynecology Clinics of North America | 1991 |
Neutrophil Function And Oral Disease
TE van Dyke, GA Hoop |
Critical Reviews in Oral Biology & Medicine | 1990 |
Peptide Growth Factors and Their Receptors II
MB Sporn, AB Roberts |
1990 | |
The Role of White Blood Cells in Post-Mortem Wounds
TT Ali |
Medicine Science and the Law | 1988 |
Potential role of activated macrophages in acetaminophen hepatotoxicity
DL Laskin, AM Pilaro, S Ji |
Toxicology and Applied Pharmacology | 1986 |
The role of complement in experimental silicosis
AH Callis, PG Sohnle, GS Mandel, NS Mandel |
Environmental Research | 1986 |
Neutrophil function and oral disease
TE Dyke, MJ Levine, RJ Genco |
Journal of Oral Pathology and Medicine | 1985 |
Biologically active complement (C5)-derived peptides and their relevance to disease
HD Perez |
Critical Reviews in Oncology/Hematology | 1984 |
Relationships among the complement, kinin, coagulation, and fibrinolytic systems
JS Sundsmo, DS Fair |
Springer Seminars in Immunopathology | 1983 |
An alkaline proteinase which has inflammatory activity isolated from guinea pig lymphoid cells
T Kambara, T Kawagoe, T Nakamura |
Biochimica et Biophysica Acta (BBA) - General Subjects | 1982 |
Unusual intracytoplasmic immunoglobulin inclusions in chronic lymphocytic leukaemia
P Guglielmi, JL Preud'homme, MF Gourdin, F Reyes, MT Daniel |
British Journal of Haematology | 1982 |
Dextran-Induced Lowering of Plasminogen Proactivator and Functionally Active High Molecular Weight Kininogen in the Rat
J Berstad, K Briseid |
Acta Pharmacologica et Toxicologica | 1982 |
Platelet factor 4 is chemotactic for neutrophils and monocytes
TF Deuel, R M, D Chang, GL Griffin, RL Heinrikson, ET Kaiser |
Proceedings of the National Academy of Sciences | 1981 |
Human Alveolar Macrophage-derived Chemotactic Factor for Neutrophils STIMULI AND PARTIAL CHARACTERIZATION
GW Hunninghake, JE Gadek, HM Fales, RG Crystal |
Journal of Clinical Investigation | 1980 |
The Influence of Serum on Random Migration and Chemotaxis of Polymorphonuclear Leucocytes: Methodological Evaluation using Sera from Infection-prone Patients and Normals
L Hakansson, P Venge |
Scandinavian Journal of Immunology | 1980 |
Effects of human complement component 1 inactivator on neutrophil chemotaxis and chemotactic deactivation
RA Patrick, JC Hollers, DY Liu, BH Giese, CW Smith |
Infection and immunity | 1980 |
Host defense against infection — Part 2
RJ Howard |
Current Problems in Surgery | 1980 |
Human plasma prekallikrein. Studies of its activation by activated factor XII and of its inactivation by diisopropyl phosphofluoridate
BN Bouma, LA Miles, G Beretta, JH Griffin |
Biochemistry | 1980 |
Neutrophil function and host resistance
B Zakhireh, LH Block, RK Root |
Infection | 1979 |
Transcutaneous Leukocyte Migration in Vivo: Cellular Kinetics, Platelet and C5a Dependent Activity
BS Goldberg, WL Weston, PF Kohler, MB Harris, JR Humbert |
Journal of Investigative Dermatology | 1979 |
Cellular, Molecular, and Clinical Aspects of Allergic Disorders
S Gupta, RA Good |
1979 | |
Purification and characterization of human vascular plasminogen activator derived from blood vessel perfusates
BR Binder, J Spragg, KF Austen |
The Journal of biological chemistry | 1979 |
Chemotaxis by polymorphonuclear leukocytes
SH Zigmond |
The Journal of Cell Biology | 1978 |
Effect of prostaglandin E2 on two different preparations of cyclic 3′,5′-nucleotide phosphodiesterase
D Egg, G Gantner |
Pharmacological Research Communications | 1978 |
Phagocytosis: A Review
MN Walters, JM Papadimitriou, WG Spector |
Critical Reviews in Toxicology | 1978 |
Acute inflammation. A review
GB Ryan, G Majno |
The American Journal of Pathology | 1977 |
Coagulopathies
JH Lewis, JA Spero, U Hasiba |
Disease-a-Month | 1977 |
Recent Developments in the Pharmacology of Inflammatory Mediators
IL Bonta |
1977 | |
Biological Amplification Systems in Immunology
NK Day, RA Good |
1977 | |
ACTIVATION AND CONTROL MECHANISMS OF THE PLASMA KININ-FORMING SYSTEM AND ITS RELATIONSHIP TO COAGULATION AND FIBRINOLYSIS
AP Kaplan |
Journal of Investigative Dermatology | 1976 |
Membrane Receptors on Neutrophils
PM Henson |
Immunological Investigations | 1976 |
Modulation of human eosinophil polymorphonuclear leukocyte migration and function
EJ Goetzl |
The American Journal of Pathology | 1976 |
Serum chemotactic inhibitory activity: heat activation of chemotactic inhibition
DE Epps, RC Williams |
Infection and immunity | 1976 |
A phagocytosis-enhancing factor in human plasma
I Gigli, BU Wintroub, EJ Goetzl |
Immunology | 1976 |
Prekallikrein and plasminogen proactivator: Absence of plasminogen proactivator in fletcher factor deficient plasma
AM Venneröd, K Laake |
Thrombosis Research | 1976 |
Clinical and physiologic studies of two siblings with prekallikrein (Fletcher factor) deficiency
WE Hathaway, KD Wuepper, WL Weston, JR Humbert, RP Rivers, E Genton, CS August, RR Montgomery, MF Mass |
The American Journal of Medicine | 1976 |
Kinins: Pharmacodynamics and Biological Roles
F Sicuteri, N Back, GL Haberland |
1976 | |
Interaction of leukocyte chemotactic factors with the cell surface. I. Chemotactic factor-induced changes in human granulocyte surface charge
JI Gallin, JR Durocher, AP Kaplan |
Journal of Clinical Investigation | 1975 |
Activation and control mechanisms of Hageman factor-dependent pathways of coagulation, fibrinolysis, and kinin generation and their contribution to the inflammatory response
AP Kaplan, KF Austen |
Journal of Allergy and Clinical Immunology | 1975 |
LASMA AND CELL-DERIVED INHIBITORS OF HUMAN NEUTROPHIL CHEMOTAXIS
EJ Goetzl |
Annals of the New York Academy of Sciences | 1975 |
ABNORMALITIES OF LEUKOCYTE CHEMOTAXIS IN HUMAN DISEASE
R Snyderman, MC Pike, LC Altman |
Annals of the New York Academy of Sciences | 1975 |
CHEMOTAXIS AND HAEMOSTASIS
AB Kay, AP Kaplan |
British Journal of Haematology | 1975 |
Leucocyte Chemotaxis: Physiological Considerations and Abnormalities
JI Gallin, SM Wolff |
Clinics in Haematology | 1975 |
Leukotaxis and leukotactic disorders. A review
PA Ward |
The American Journal of Pathology | 1974 |
The hageman factor dependent pathways of human plasma
AP Kaplan |
Microvascular Research | 1974 |
Mediators of Inflammation
G Weissmann |
Mediators of Inflammation | 1974 |
Immunopharmacology
BB Levine |
Immunopharmacology | 1968 |