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Usage Information

Enhanced Effects of Prostaglandin E1 and Dibutyryl Cyclic AMP upon Human Lymphocytes in the Presence of Cortisol
John Mendelsohn, … , Michael M. Multer, Robert F. Boone
John Mendelsohn, … , Michael M. Multer, Robert F. Boone
Published September 1, 1973
Citation Information: J Clin Invest. 1973;52(9):2129-2137. https://doi.org/10.1172/JCI107397.
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Research Article

Enhanced Effects of Prostaglandin E1 and Dibutyryl Cyclic AMP upon Human Lymphocytes in the Presence of Cortisol

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Abstract

The combined effects of cortisol and agents acting through a cyclic AMP-mediated mechanism have been studied in cultures of highly purified human peripheral lymphocytes. Incubation with prostaglandin E1 (PGE1), dibutyryl cyclic AMP, or cortisol results in a concentration-dependent inhibition of [3H]-thymidine incorporation by both unstimulated and phytohemagglutinin (PHA)-stimulated lymphocytes, and PHA-induced morphologic transformation is prevented. When cortisol and PGE1 (or dibutyryl cyclic AMP) are added together to lymphocyte cultures, enhanced inhibitory effects are observed.

Authors

John Mendelsohn, Michael M. Multer, Robert F. Boone

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Usage data is cumulative from May 2024 through May 2025.

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