Kenneth L. Brigham, James D. Snell Jr.
Citation Information: J Clin Invest. 1973;52(8):2041-2052. https://doi.org/10.1172/JCI107388.
Kenneth L. Brigham, James D. Snell Jr.
Published August 1, 1973
Citation Information: J Clin Invest. 1973;52(8):2041-2052. https://doi.org/10.1172/JCI107388.
Abstract
During single pass indicator studies across the lungs [14C]urea remains in the vascular compartment, but its molecular size and solubility suggest it might escape abnormally permeable vessels. To test the hypothesis that [14C]urea might be used to distinguish pulmonary edema due to acutely increased intravascular pressure from that due to vascular damage by alloxan, we studied [51Cr]erythrocytes (r), [125I]albumin (a), [14C]urea (u), and tritiated water as dilution indicators in the pulmonary circulation of anesthetized dogs. In addition, the adequacy of albumin as an intravascular indicator was evaluated.
Authors
Kenneth L. Brigham, James D. Snell Jr.
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