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Concise Publication Free access | 10.1172/JCI107262

Formation of Prostaglandins during the Aggregation of Human Blood Platelets

J. B. Smith, Carol Ingerman, J. J. Kocsis, and M. J. Silver

1Cardeza Foundation and Department of Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107

Find articles by Smith, J. in: PubMed | Google Scholar

1Cardeza Foundation and Department of Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107

Find articles by Ingerman, C. in: PubMed | Google Scholar

1Cardeza Foundation and Department of Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107

Find articles by Kocsis, J. in: PubMed | Google Scholar

1Cardeza Foundation and Department of Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107

Find articles by Silver, M. in: PubMed | Google Scholar

Published April 1, 1973 - More info

Published in Volume 52, Issue 4 on April 1, 1973
J Clin Invest. 1973;52(4):965–969. https://doi.org/10.1172/JCI107262.
© 1973 The American Society for Clinical Investigation
Published April 1, 1973 - Version history
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Abstract

Prostaglandins E2 and F2α were formed in response to ADP, L-epinephrine, or collagen by human platelets suspended in plasma containing citrate anticoagulant and stirred at 37°C. The prostaglandins formed by platelets in response to collagen were rapidly released and the amounts formed were proportional to the amount of collagen added. The formation of the prostaglandins was associated with the single wave of aggregation induced by collagen or the second wave of aggregation induced by epinephrine. The above findings are discussed with reference to published studies on the biochemical changes occurring during platelet aggregation. It is suggested that the formation and release of prostaglandins is associated with the secretion of endogenous ADP and 5-hydroxytryptamine.

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