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Usage Information

Evidence for Stimulation of Renal Gluconeogenesis by Catecholamines
Kiyoshi Kurokawa, Shaul G. Massry
Kiyoshi Kurokawa, Shaul G. Massry
Published April 1, 1973
Citation Information: J Clin Invest. 1973;52(4):961-964. https://doi.org/10.1172/JCI107261.
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Concise Publication

Evidence for Stimulation of Renal Gluconeogenesis by Catecholamines

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Abstract

Isoproterenol and norepinephrine (10-4 M) significantly increased cyclic AMP formation and glucose production by the isolated tubules of the renal cortex of the rat. These effects were abolished by propranolol. Theophylline diminished the effects of the catecholamines on gluconeogenesis despite a marked augmentation in cyclic AMP concentration. In the absence of calcium ion in the incubation medium, isoproterenol stimulates cyclic AMP production, but has no effect on gluconeogenesis. It is concluded that catecholamines enhance gluconeogenesis in renal cortical tubules by the stimulation of beta adrenergic receptors. This effect is probably mediated through adenyl cyclase-cyclic AMP system and requires an adequate level of ATP and the presence of calcium ion.

Authors

Kiyoshi Kurokawa, Shaul G. Massry

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Usage data is cumulative from May 2024 through May 2025.

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Text version 119 4
PDF 49 8
Scanned page 159 3
Citation downloads 49 0
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