Citations to this article

Biological Defense Mechanisms. THE PRODUCTION BY LEUKOCYTES OF SUPEROXIDE, A POTENTIAL BACTERICIDAL AGENT
Bernard M. Babior, … , Ruby S. Kipnes, John T. Curnutte
Bernard M. Babior, … , Ruby S. Kipnes, John T. Curnutte
Published March 1, 1973
Citation Information: J Clin Invest. 1973;52(3):741-744. https://doi.org/10.1172/JCI107236.
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Biological Defense Mechanisms. THE PRODUCTION BY LEUKOCYTES OF SUPEROXIDE, A POTENTIAL BACTERICIDAL AGENT

Abstract

As a highly reactive substance produced in biological systems by the one-electron reduction of oxygen, superoxide (O2-) seemed a likely candidate as a bactericidal agent in leukocytes. The reduction of cytochrome c, a process in which O2- may serve as an electron donor, was found to occur when the cytochrome was incubated with leukocytes. O2- was identified as the agent responsible for the leukocyte-mediated reduction of cytochrome c by the demonstration that the reaction was abolished by superoxide dismutase, an enzyme that destroys O2-, but not by boiled dismutase, albumin, or catalase.

Authors

Bernard M. Babior, Ruby S. Kipnes, John T. Curnutte

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