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Research Article Free access | 10.1172/JCI107234

Sites of Formation of the Serum Proteins Transferrin and Hemopexin

G. J. Thorbecke, H. H. Liem, S. Knight, K. Cox, and U. Muller-Eberhard

Department of Pathology, New York University School of Medicine, New York 10016

Department of Biochemistry, Scripps Clinic and Research Foundation, and Division of Pediatric Hematology, University of California at San Diego, La Jolla, California 92037

Find articles by Thorbecke, G. in: PubMed | Google Scholar

Department of Pathology, New York University School of Medicine, New York 10016

Department of Biochemistry, Scripps Clinic and Research Foundation, and Division of Pediatric Hematology, University of California at San Diego, La Jolla, California 92037

Find articles by Liem, H. in: PubMed | Google Scholar

Department of Pathology, New York University School of Medicine, New York 10016

Department of Biochemistry, Scripps Clinic and Research Foundation, and Division of Pediatric Hematology, University of California at San Diego, La Jolla, California 92037

Find articles by Knight, S. in: PubMed | Google Scholar

Department of Pathology, New York University School of Medicine, New York 10016

Department of Biochemistry, Scripps Clinic and Research Foundation, and Division of Pediatric Hematology, University of California at San Diego, La Jolla, California 92037

Find articles by Cox, K. in: PubMed | Google Scholar

Department of Pathology, New York University School of Medicine, New York 10016

Department of Biochemistry, Scripps Clinic and Research Foundation, and Division of Pediatric Hematology, University of California at San Diego, La Jolla, California 92037

Find articles by Muller-Eberhard, U. in: PubMed | Google Scholar

Published March 1, 1973 - More info

Published in Volume 52, Issue 3 on March 1, 1973
J Clin Invest. 1973;52(3):725–731. https://doi.org/10.1172/JCI107234.
© 1973 The American Society for Clinical Investigation
Published March 1, 1973 - Version history
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Abstract

Sites of synthesis of hemopexin and transferrin were determined by culturing various tissues of rabbits and monkeys in the presence of labeled amino acids. Labeling of the serum proteins was examined by means of autoradiographs of immunoelectrophoretic patterns as well as by precipitation in the test tubes employing immunospecific antisera. Good correlation was seen between the results obtained by the two different methods. The liver was found to be the only site of many tissues studied that synthesized hemopexin. Transferrin production was observed in the liver, submaxillary gland, lactating mammary gland, testis, and ovary.

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