Glucose Utilization and Production by the Dog Kidney In Vivo in Metabolic Acidosis and Alkalosis

J. Costello; J. M. Scott; P. Wilson; E. Bourke

doi:10.1172/JCI107222

Published March 1, 1973 - More info

View PDF

Abstract

Using D-[1-¹⁴C]glucose as a tracer, renal glucose utilization and production was measured in chronic metabolic acidosis and alkalosis in dog kidney in vivo. In six experiments in acidosis, mean total renal glucose production was 4.447±1.655 SE μmol/min and glucose utilization was 4.187±0.576 SE μmol/min. In five alkalotic experiments it was found that mean total glucose production was 12.227±2.026 SE μmol/min and glucose utilization was 18.186±2.054 SE μmol/min. Renal glucose utilization and production are therefore significantly higher in alkalosis than in acidosis in vivo. Since glucose production is maximal under conditions when glutamine extraction is minimal (i.e. alkalosis), it is apparent that in alkalosis glutamine is not a major precursor of glucose.

Glucose Utilization and Production by the Dog Kidney In Vivo in Metabolic Acidosis and Alkalosis

J. Costello, J. M. Scott, P. Wilson, and E. Bourke

Article tools

Metrics

Go to

Glucose Utilization and Production by the Dog Kidney In Vivo in Metabolic Acidosis and Alkalosis

J. Costello, J. M. Scott, P. Wilson, and E. Bourke

Article tools

Metrics

Go to

Sign up for email alerts