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Research Article Free access | 10.1172/JCI107214

The Stimulation of 1,25-Dihydroxycholecalciferol Metabolism in Vitamin D-deficient Rats by 1,25-Dihydroxycholecalciferol Treatment

C. A. Frolik and H. F. DeLuca

Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin at Madison, Madison, Wisconsin 53706

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Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin at Madison, Madison, Wisconsin 53706

Find articles by DeLuca, H. in: PubMed | Google Scholar

Published March 1, 1973 - More info

Published in Volume 52, Issue 3 on March 1, 1973
J Clin Invest. 1973;52(3):543–548. https://doi.org/10.1172/JCI107214.
© 1973 The American Society for Clinical Investigation
Published March 1, 1973 - Version history
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Abstract

Daily oral administration of 1,25-dihydroxycholecalciferol to vitamin D-deficient rats increases the rate of disappearance of [3H]1,25-dihydroxycholecalciferol and increases the rate of appearance of metabolites both less polar and more polar than 1,25-dihydroxycholecalciferol in the intestine, bone, liver, kidney, plasma, and muscle. Since 1,25-dihydroxycholecalciferol is believed to be the metabolically active form of vitamin D in the stimulation of intestinal calcium transport and bone calcium mobilization, these results provide an explanation for the fact that daily oral administration of 1,25-dihydroxycholecalciferol is relatively ineffective in the maintenance of serum calcium and in the calcification of bone in rats.

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