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Research Article Free access | 10.1172/JCI107155

Mode of Action of Chemotherapy In Vivo on Human Acute Leukemia. I. DAUNOMYCIN

Pierre A. Stryckmans, Joseph Manaster, Françoise Lachapelle, and Mireille Socqouet

Service de Médecine Interne et d'Investigation Clinique de l'Institut Jules Bordet, Centre des Tumeurs de l'Université Libre de Bruxelles, Brussels, Belgium

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Service de Médecine Interne et d'Investigation Clinique de l'Institut Jules Bordet, Centre des Tumeurs de l'Université Libre de Bruxelles, Brussels, Belgium

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Service de Médecine Interne et d'Investigation Clinique de l'Institut Jules Bordet, Centre des Tumeurs de l'Université Libre de Bruxelles, Brussels, Belgium

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Service de Médecine Interne et d'Investigation Clinique de l'Institut Jules Bordet, Centre des Tumeurs de l'Université Libre de Bruxelles, Brussels, Belgium

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Published January 1, 1973 - More info

Published in Volume 52, Issue 1 on January 1, 1973
J Clin Invest. 1973;52(1):126–133. https://doi.org/10.1172/JCI107155.
© 1973 The American Society for Clinical Investigation
Published January 1, 1973 - Version history
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Abstract

The leukocytes of 16 adult patients with acute myeloblastic leukemia were studied by autoradiographic methods to elucidate the mode of action of daunomycin.

It was shown that daunomycin, at clinically useful doses, exhibits a cytolytic effect on all leukemic blasts whatever their cell-cycle phase. This cytolytic action affects, however, preferentially S-phase cells.

It was shown also that blasts of patients less sensitive to daunomycin or receiving a lesser dose of the drug are temporarily blocked in G2 phase (delayed mitosis) or in G2 phase (prolonged generation time).

Finally daunomycin appeared to hamper the passage of G2-blocked blasts from the bone marrow to the blood, while G2-phase cells crossed freely.

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Version history
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