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Concise Publication Free access | 10.1172/JCI107123
Dermatology Service, Walter Reed General Hospital, Washington, D. C. 20012
Digestive and Hereditary Diseases Branch, National Institute of Arthritis and Metabolic Diseases, Bethesda, Maryland 20014
Immunology Branch, National Cancer Institute, Bethesda, Maryland 20014
Metabolism Branch, National Cancer Institute, Bethesda, Maryland 20014
Find articles by Katz, S. in: JCI | PubMed | Google Scholar
Dermatology Service, Walter Reed General Hospital, Washington, D. C. 20012
Digestive and Hereditary Diseases Branch, National Institute of Arthritis and Metabolic Diseases, Bethesda, Maryland 20014
Immunology Branch, National Cancer Institute, Bethesda, Maryland 20014
Metabolism Branch, National Cancer Institute, Bethesda, Maryland 20014
Find articles by Falchuk, Z. in: JCI | PubMed | Google Scholar
Dermatology Service, Walter Reed General Hospital, Washington, D. C. 20012
Digestive and Hereditary Diseases Branch, National Institute of Arthritis and Metabolic Diseases, Bethesda, Maryland 20014
Immunology Branch, National Cancer Institute, Bethesda, Maryland 20014
Metabolism Branch, National Cancer Institute, Bethesda, Maryland 20014
Find articles by Dahl, M. in: JCI | PubMed | Google Scholar
Dermatology Service, Walter Reed General Hospital, Washington, D. C. 20012
Digestive and Hereditary Diseases Branch, National Institute of Arthritis and Metabolic Diseases, Bethesda, Maryland 20014
Immunology Branch, National Cancer Institute, Bethesda, Maryland 20014
Metabolism Branch, National Cancer Institute, Bethesda, Maryland 20014
Find articles by Rogentine, G. in: JCI | PubMed | Google Scholar
Dermatology Service, Walter Reed General Hospital, Washington, D. C. 20012
Digestive and Hereditary Diseases Branch, National Institute of Arthritis and Metabolic Diseases, Bethesda, Maryland 20014
Immunology Branch, National Cancer Institute, Bethesda, Maryland 20014
Metabolism Branch, National Cancer Institute, Bethesda, Maryland 20014
Find articles by Strober, W. in: JCI | PubMed | Google Scholar
Published November 1, 1972 - More info
Histocompatibility antigen HL-A8 was found in 58% of 26 patients with dermatitis herpetiformis (DH) compared to 24% of a normal group. This difference in antigen frequency is significant at the P < 0.003 level. In a previous study, the frequency of this same genetic marker was found to be significantly increased in patients with gluten-sensitive enteropathy (GSE) (88% in patients vs. 22% in controls). The finding of an increased incidence of the HL-A8 antigen in both DH and GSE supports the concept that these diseases are related and provides a genetic basis for the association between the two.
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