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Concise Publication Free access | 10.1172/JCI107123

HL-A8: a genetic link between dermatitis herpetiformis and gluten-sensitive enteropathy

Stephen I. Katz, Z. Myron Falchuk, Mark V. Dahl, G. Nicholas Rogentine, and Warren Strober

Dermatology Service, Walter Reed General Hospital, Washington, D. C. 20012

Digestive and Hereditary Diseases Branch, National Institute of Arthritis and Metabolic Diseases, Bethesda, Maryland 20014

Immunology Branch, National Cancer Institute, Bethesda, Maryland 20014

Metabolism Branch, National Cancer Institute, Bethesda, Maryland 20014

Find articles by Katz, S. in: PubMed | Google Scholar

Dermatology Service, Walter Reed General Hospital, Washington, D. C. 20012

Digestive and Hereditary Diseases Branch, National Institute of Arthritis and Metabolic Diseases, Bethesda, Maryland 20014

Immunology Branch, National Cancer Institute, Bethesda, Maryland 20014

Metabolism Branch, National Cancer Institute, Bethesda, Maryland 20014

Find articles by Falchuk, Z. in: PubMed | Google Scholar

Dermatology Service, Walter Reed General Hospital, Washington, D. C. 20012

Digestive and Hereditary Diseases Branch, National Institute of Arthritis and Metabolic Diseases, Bethesda, Maryland 20014

Immunology Branch, National Cancer Institute, Bethesda, Maryland 20014

Metabolism Branch, National Cancer Institute, Bethesda, Maryland 20014

Find articles by Dahl, M. in: PubMed | Google Scholar

Dermatology Service, Walter Reed General Hospital, Washington, D. C. 20012

Digestive and Hereditary Diseases Branch, National Institute of Arthritis and Metabolic Diseases, Bethesda, Maryland 20014

Immunology Branch, National Cancer Institute, Bethesda, Maryland 20014

Metabolism Branch, National Cancer Institute, Bethesda, Maryland 20014

Find articles by Rogentine, G. in: PubMed | Google Scholar

Dermatology Service, Walter Reed General Hospital, Washington, D. C. 20012

Digestive and Hereditary Diseases Branch, National Institute of Arthritis and Metabolic Diseases, Bethesda, Maryland 20014

Immunology Branch, National Cancer Institute, Bethesda, Maryland 20014

Metabolism Branch, National Cancer Institute, Bethesda, Maryland 20014

Find articles by Strober, W. in: PubMed | Google Scholar

Published November 1, 1972 - More info

Published in Volume 51, Issue 11 on November 1, 1972
J Clin Invest. 1972;51(11):2977–2980. https://doi.org/10.1172/JCI107123.
© 1972 The American Society for Clinical Investigation
Published November 1, 1972 - Version history
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Abstract

Histocompatibility antigen HL-A8 was found in 58% of 26 patients with dermatitis herpetiformis (DH) compared to 24% of a normal group. This difference in antigen frequency is significant at the P < 0.003 level. In a previous study, the frequency of this same genetic marker was found to be significantly increased in patients with gluten-sensitive enteropathy (GSE) (88% in patients vs. 22% in controls). The finding of an increased incidence of the HL-A8 antigen in both DH and GSE supports the concept that these diseases are related and provides a genetic basis for the association between the two.

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