Advertisement

Concise Publication Free access | 10.1172/JCI107065

Hormonal control of the renal conversion of 25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol

Howard Rasmussen, Mitzi Wong, Daniel Bikle, and David B. P. Goodman

1Department of Biochemistry, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104

Find articles by Rasmussen, H. in: JCI | PubMed | Google Scholar

1Department of Biochemistry, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104

Find articles by Wong, M. in: JCI | PubMed | Google Scholar

1Department of Biochemistry, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104

Find articles by Bikle, D. in: JCI | PubMed | Google Scholar

1Department of Biochemistry, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104

Find articles by Goodman, D. in: JCI | PubMed | Google Scholar

Published September 1, 1972 - More info

Published in Volume 51, Issue 9 on September 1, 1972
J Clin Invest. 1972;51(9):2502–2504. https://doi.org/10.1172/JCI107065.
© 1972 The American Society for Clinical Investigation
Published September 1, 1972 - Version history
View PDF
Abstract

Isolated renal tubules from vitamin D-deficient chicks catalyse the in vitro conversion of 25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol. This conversion is stimulated by 5 × 10-10 M bovine parathyroid hormone, or by 10-6 M cyclic AMP. It is inhibited by 10-9 M porcine calcitonin. It is concluded that these hormonal controls of the synthesis of the renal hormone 1,25-dihydroxycholecalciferol are of particular physiological significance in coordinating the activities of the various organs involved in extracellular calcium homeostasis.

Browse pages

Click on an image below to see the page. View PDF of the complete article

Version history
  • Version 1 (September 1, 1972): No description
Advertisement
Advertisement