HL-A antigens and disease: <i>Acute lymphocytic leukemia</i>

G. Nicholas Rogentine; R. A. Yankee; J. J. Gart; J. Nam; R. J. Trapani

doi:10.1172/JCI107055

^{Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014}

^{Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014}

^{Biometry Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014}

^{Microbiological Associates, Inc., Bethesda, Maryland 20014}

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^{Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014}

^{Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014}

^{Biometry Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014}

^{Microbiological Associates, Inc., Bethesda, Maryland 20014}

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^{Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014}

^{Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014}

^{Biometry Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014}

^{Microbiological Associates, Inc., Bethesda, Maryland 20014}

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^{Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014}

^{Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014}

^{Biometry Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014}

^{Microbiological Associates, Inc., Bethesda, Maryland 20014}

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^{Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014}

^{Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014}

^{Biometry Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014}

^{Microbiological Associates, Inc., Bethesda, Maryland 20014}

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Published in Volume 51, Issue 9 on September 1, 1972
J Clin Invest. 1972;51(9):2420–2428. https://doi.org/10.1172/JCI107055.
© 1972 The American Society for Clinical Investigation

Published September 1, 1972 - Version history

50 Caucasian children with acute lymphocytic leukemia (ALL) and 219 members of their families have been genotyped for 15 antigens of the HL-A system. The antigen and gene frequencies for HL-A2 were significantly higher in the patient population than in a 200 member normal Caucasian panel. No other antigen frequencies were significantly elevated. All antigens typed for were found in the patients. No antigen gain or loss was detected in the leukemic cells.