Usage Information

Effect of prostaglandin E1 on certain renal actions of parathyroid hormone
Nama P. Beck, … , James B. Field, Bernard B. Davis
Nama P. Beck, … , James B. Field, Bernard B. Davis
Published September 1, 1972
Citation Information: J Clin Invest. 1972;51(9):2352-2358. https://doi.org/10.1172/JCI107047.
View: Text | PDF
Research Article

Effect of prostaglandin E1 on certain renal actions of parathyroid hormone

Abstract

Parathyroid hormone increased basal adenyl cyclase activity and that increase was inhibited by prostaglandin E1 (PGE1). Tissue cyclic 3′,5′-adenosine monophosphate (cyclic AMP) concentrations were increased by parathyroid hormone and that increase was likewise inhibited by PGE1. Both parathyroid hormone and dibutyryl cyclic AMP increased 32P incorporation into renal cortical phospholipids. PGE1 diminished the effect of parathyroid hormone but not dibutyryl cyclic AMP to influence that parameter. PGE1 likewise modulated the effect of parathyroid hormone but not dibutyryl cyclic AMP to decrease fractional phosphate reabsorption by the renal tubule. It is suggested that PGE1 inhibits the effect of parathyroid hormone by decreasing its effect on adenyl cyclase. Such interaction may be important in modulating the intracellular action of parathyroid hormone on kidney cortex.

Authors

Nama P. Beck, Frederick R. DeRubertis, Michael F. Michelis, Robert D. Fusco, James B. Field, Bernard B. Davis

×

Usage data is cumulative from January 2024 through January 2025.

Usage JCI PMC
Text version 72 0
PDF 41 19
Scanned page 184 3
Citation downloads 36 0
Totals 333 22
Total Views 355
(Click and drag on plot area to zoom in. Click legend items above to toggle)

Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

Advertisement