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Research Article Free access | 10.1172/JCI107041

Effects of carbon tetrachloride on albumin synthesis

Marcus A. Rothschild, Murray Oratz, and Sidney S. Schreiber

Radioisotope Service, New York Veterans Administration Hospital, New York 10010

Department of Medicine, New York University School of Medicine, New York 10010

Department of Biochemistry, New York University College of Dentistry, New York 10010

Find articles by Rothschild, M. in: JCI | PubMed | Google Scholar

Radioisotope Service, New York Veterans Administration Hospital, New York 10010

Department of Medicine, New York University School of Medicine, New York 10010

Department of Biochemistry, New York University College of Dentistry, New York 10010

Find articles by Oratz, M. in: JCI | PubMed | Google Scholar

Radioisotope Service, New York Veterans Administration Hospital, New York 10010

Department of Medicine, New York University School of Medicine, New York 10010

Department of Biochemistry, New York University College of Dentistry, New York 10010

Find articles by Schreiber, S. in: JCI | PubMed | Google Scholar

Published September 1, 1972 - More info

Published in Volume 51, Issue 9 on September 1, 1972
J Clin Invest. 1972;51(9):2310–2314. https://doi.org/10.1172/JCI107041.
© 1972 The American Society for Clinical Investigation
Published September 1, 1972 - Version history
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Abstract

The effects of CCl4 on albumin synthesis were studied employing the isolated perfused liver. Carbonate-14C was used to measure newly synthesized albumin. 2.5 ml of CCl4 was administered by stomach tube 2 hr before perfusion. Albumin synthesis decreased from 36 to 5 mg following the ingestion of CCl4. Preperfusing the livers for 1 hr before measuring albumin synthesis resulted in an increase to 12 mg, and the addition of tryptophan to a final concentration of 10 mM resulted in a further increase to 19 mg. Cortisone did not protect against the toxic effects of CCl4 when administered to the donor rabbits. Fasting resulted in an increased sensitivity to CCl4 and an antioxidant was not effective in protecting against the toxic manifestations of CCl4.

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