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Research Article Free access | 10.1172/JCI107033

Adrenocortical steroidogenesis: the effects of prostaglandins

Takao Saruta and Norman M. Kaplan

Department of Internal Medicine, The University of Texas Southwestern Medical School, Dallas, Texas 75235

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Department of Internal Medicine, The University of Texas Southwestern Medical School, Dallas, Texas 75235

Find articles by Kaplan, N. in: JCI | PubMed | Google Scholar

Published September 1, 1972 - More info

Published in Volume 51, Issue 9 on September 1, 1972
J Clin Invest. 1972;51(9):2246–2251. https://doi.org/10.1172/JCI107033.
© 1972 The American Society for Clinical Investigation
Published September 1, 1972 - Version history
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Abstract

Prostaglandins E1 and E2 significantly stimulated the synthesis of aldosterone, corticosterone, and to a lesser degree, cortisol in the outer slices of beef adrenal tissue. PGA, PGF1a, and PGF2a were ineffective.

PGE1 was found to stimulate steroidogenesis in a manner similar to that of adrenocorticotropin (ACTH) in (a) needing calcium, (b) being inhibited by puromycin but not actinomycin D, (c) increasing the levels of cyclic AMP, and (d) not having an additive effect to exogenous cyclic AMP. PGE1 did not produce an additive effect with either submaximal or maximal amounts of ACTH but did have an additive effect with angiotensin.

These results are in keeping with the hypothesis that PGE1 shares a receptor site on the plasma membrane with ACTH.

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