The formation of abnormal bile and cholesterol gallstones from dietary cholesterol in the prairie dog

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Abstract

To study the pathogenesis of cholesterol gallstones, we fed 24 adult male prairie dogs a high cholesterol, egg yolk diet. 13 control animals received a cholesterol-free diet. All animals fed the egg yolk diet formed multiple gallstones in 2-6 months' time. These stones contained cholesterol, 77±14% by dry weight. No stones ocurred in the control group.

Authors

D. E. Brenneman, William E. Connor, E. L. Forker, Larry DenBesten