Citations to this article

The Effect of Calcium and Other Salts upon the Release of Glucagon-Like Immunoreactivity from the Gut
Ingolf Böttger, … , Gerald R. Faloona, Roger H. Unger
Ingolf Böttger, … , Gerald R. Faloona, Roger H. Unger
Published April 1, 1972
Citation Information: J Clin Invest. 1972;51(4):831-836. https://doi.org/10.1172/JCI106878.
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Research Article

The Effect of Calcium and Other Salts upon the Release of Glucagon-Like Immunoreactivity from the Gut

Abstract

It has been suggested that glucagon-like immunoreactivity (GLI) of gastrointestinal tissues might, like pancreatic glucagon, have calcium-lowering activity. Studies were designed, therefore, to determine if calcium absorption was associated with GLI release from the gut. The intraduodenal administration of 4.5 mmoles of calcium chloride per kg of body weight to conscious dogs was associated with a prompt rise in plasma GLI from a base line of 2.2 ng/ml (SEM ±0.2) to a peak of 4.3 ng/ml (SEM ±0.3) at 45 and 60 min, in association with a rise of plasma calcium from 8.6 to 10.4 mg/100 ml. Neither pancreatic glucagon, insulin, nor glucose changed. Smaller calcium loads had progressively diminishing effects on GLI release. Calcium lactate also appeared to stimulate effectively GLI release. Both magnesium chloride and sodium chloride given intraduodenally were associated with a significant though modest increase in GLI.

Authors

Ingolf Böttger, Gerald R. Faloona, Roger H. Unger

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Total citations by year

Year: 1980 1979 1977 1976 1975 1974 1973 Total
Citations: 1 1 1 3 5 4 5 20
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Citations to this article (20)

Title and authors Publication Year
Augmentation of Insulin Secretion by a Non-Nutrient Drink
NJ Goldberg, TD Wingert, SR Levin, RI Adachi 		Gastroenterology 1980
Contemporary Metabolism
N Freinkel 		1979
Calcium, glucose and glucagon release
J Iversen, K Hermansen 		Diabetologia 1977
The role of calcium in glucagon release, interactions between glucose and calcium
V Leclercq-Meyer, J Marchand, WJ Malaisse 		Diabetologia 1976
Pancreatic, Gallbladder, and Gastric Responses to Intraduodenal Calcium Perfusion in Man
KH Holtermuller, , JT Mccall, VL M.D. 		Gastroenterology 1976
The Enteroglucagon Response to Intrajejunal Infusion of Glucose, Triglycerides, and Sodium Chloride, and Its Relation to Jejunal Inhibition of Gastric Acid Secretion in Man
JJ Holst, J Christiansen, C Kühl 		Scandinavian Journal of Gastroenterology 1976
Identification of glucagon in the gastrointestinal tract
H Sasaki, B Rubalcava, D Baetens, E Blazquez, CB Srikant, L Orci, RH Unger 		Journal of Clinical Investigation 1975
Diabetes mellitus · A
E Cerasi, P Dieterle, H Ege, A Englhardt, H Frerichs, W Gepts, A Hasselblatt, HR Henrichs, L Herberg, JJ Hoet, H Hungerland, K Jahnke, RJ Jarrett, G Jörgensen, KH Jørgensen, H Kasemir, H Keen, L Kerp, V Leclercq-Meyer, H Liebermeister, G Löffler, R Luft, WJ Malaisse, J Markussen, M Möllering, H Schadewaldt, J Schlichtkrull, K Schöffling, U Schwedes, PC Scriba, F Sundby, KH Usadel, L Weiss, H Zimmermann, K Oberdisse 		1975
The effect of somatostatin on the response of GLI to the intraduodenal administration of glucose, protein, and fat
H Sakurai, RE Dobbs, RH Unger 		Diabetologia 1975
Characterization of Circulating Immunoreactive Glucagon in Response to Intraduodenal Administration of Fat in Dogs
A Ohneda, A Yanbe, Y Maruhama, S Ishii, Y Kai, R Abe, S Yamagata 		Gastroenterology 1975
Studies on Pentagastrin-Induced Hypocalcaemia in Lactating Cows
J Luthman, J Persson, SO Jacobsson 		Acta veterinaria Scandinavica 1975
EARLY NEONATAL HYPOCALCÆMIA
L Bergman 		The Lancet 1974
LITHIUM AND HALOPERIDOL IN MOVEMENT DISORDERS
JA McCaul, GM Stern 		The Lancet 1974
Candidate Hormones of the Gut
MI Grossman 		Gastroenterology 1974
The Neuroendocrine Design of the Gut
GM Makhlouf 		Gastroenterology 1974
The Effects of Triglyceride Absorption upon Glucagon, Insulin, and Gut Glucagon-Like Immunoreactivity
I Böttger, R Dobbs, GR Faloona, RH Unger 		Journal of Clinical Investigation 1973
Neunundsiebzigster Kongress
K Miehlke 		1973
Increased serum immunoreactive insulin in rabbits fed a protein- and mineral-rich diet
LG Heding, H Andersen 		Diabetologia 1973
Calcium and Gastric Secretion
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Glucagon as a Hypocalcemic and Hypophosphatemic Agent in the Rat
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