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Research Article Free access | 10.1172/JCI106831

Peripheral Aromatic L-Amino Acids Decarboxylase Inhibitor in Parkinsonism. I. EFFECT ON O-METHYLATED METABOLITES OF L-DOPA-2-14C

F. S. Messiha, T. H. Hsu, and J. R. Bianchine

1Maryland Psychiatric Research Center, Pharmacology Unit, Department of Health and Mental Hygiene, Johns Hopkins University, School of Medicine and Baltimore City Hospitals, Baltimore, Maryland 21228

Find articles by Messiha, F. in: PubMed | Google Scholar

1Maryland Psychiatric Research Center, Pharmacology Unit, Department of Health and Mental Hygiene, Johns Hopkins University, School of Medicine and Baltimore City Hospitals, Baltimore, Maryland 21228

Find articles by Hsu, T. in: PubMed | Google Scholar

1Maryland Psychiatric Research Center, Pharmacology Unit, Department of Health and Mental Hygiene, Johns Hopkins University, School of Medicine and Baltimore City Hospitals, Baltimore, Maryland 21228

Find articles by Bianchine, J. in: PubMed | Google Scholar

Published February 1, 1972 - More info

Published in Volume 51, Issue 2 on February 1, 1972
J Clin Invest. 1972;51(2):452–455. https://doi.org/10.1172/JCI106831.
© 1972 The American Society for Clinical Investigation
Published February 1, 1972 - Version history
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Abstract

The effects of MK-486, an inhibitor of peripheral aromatic L-amino acids decarboxylase, on the urinary metabolites derived from orally administered L-Dopa-2-14C were studied in three Parkinsonian patients. Treatment with MK-486 before L-Dopa-2-14C markedly reduced radioactivity found in catecholamines fraction by 70-80% during 48 hr, but increased 3-O-methyldopa fraction by threefold, as compared with a nonpretreated base line value. Pretreatment with MK-486 for a period of 1 wk resulted in less inhibition of O-methylated amine and acid metabolite fractions than that measured after a single dose of the inhibitor.

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