Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
Top
  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal
  • Top
  • Abstract
  • Version history
  • Article usage
  • Citations to this article

Advertisement

Research Article Free access | 10.1172/JCI106824

Plasma Aldosterone Concentration at Delivery and during the Newborn Period

Inese Z. Beitins, Francis Bayard, Lynne Levitsky, Isadore G. Ances, Avinoam Kowarski, and Claude J. Migeon

Harriet Lane Service of the Children's Medical and Surgical Center, The Johns Hopkins Hospital and University, Baltimore, Maryland 21205

Department of Pediatrics, the University of Maryland 21201

Department of Obstetrics and Gynecology, the University of Maryland 21201

Find articles by Beitins, I. in: PubMed | Google Scholar

Harriet Lane Service of the Children's Medical and Surgical Center, The Johns Hopkins Hospital and University, Baltimore, Maryland 21205

Department of Pediatrics, the University of Maryland 21201

Department of Obstetrics and Gynecology, the University of Maryland 21201

Find articles by Bayard, F. in: PubMed | Google Scholar

Harriet Lane Service of the Children's Medical and Surgical Center, The Johns Hopkins Hospital and University, Baltimore, Maryland 21205

Department of Pediatrics, the University of Maryland 21201

Department of Obstetrics and Gynecology, the University of Maryland 21201

Find articles by Levitsky, L. in: PubMed | Google Scholar

Harriet Lane Service of the Children's Medical and Surgical Center, The Johns Hopkins Hospital and University, Baltimore, Maryland 21205

Department of Pediatrics, the University of Maryland 21201

Department of Obstetrics and Gynecology, the University of Maryland 21201

Find articles by Ances, I. in: PubMed | Google Scholar

Harriet Lane Service of the Children's Medical and Surgical Center, The Johns Hopkins Hospital and University, Baltimore, Maryland 21205

Department of Pediatrics, the University of Maryland 21201

Department of Obstetrics and Gynecology, the University of Maryland 21201

Find articles by Kowarski, A. in: PubMed | Google Scholar

Harriet Lane Service of the Children's Medical and Surgical Center, The Johns Hopkins Hospital and University, Baltimore, Maryland 21205

Department of Pediatrics, the University of Maryland 21201

Department of Obstetrics and Gynecology, the University of Maryland 21201

Find articles by Migeon, C. in: PubMed | Google Scholar

Published February 1, 1972 - More info

Published in Volume 51, Issue 2 on February 1, 1972
J Clin Invest. 1972;51(2):386–394. https://doi.org/10.1172/JCI106824.
© 1972 The American Society for Clinical Investigation
Published February 1, 1972 - Version history
View PDF
Abstract

Aldosterone concentrations in plasma of women on normal sodium intake undergoing cesarean section were 3.7±1.4 ng/100 ml (mean±1 SD). These values were significantly lower (P < 0.001) than those observed in mothers on normal sodium diet, delivered by the vaginal route (14.9±7.0 ng/100 ml). A significant elevation (P < 0.001) of the concentrations was found if the mothers had been on sodium restriction and/or diuretics (44.9±24.2 ng/100 ml). In supine position, adult nonpregnant subjects have aldosterone concentrations in plasma of 1.7±1.4 ng/100 ml on normal sodium intake and of 16.7±8.1 ng/100 ml on low sodium diet.

Simultaneous determinations of aldosterone levels in cord blood showed that cord values were significantly higher than those of the corresponding mother (P < 0.01 by paired t test). However, values in cord blood of infants born to mothers on a normal sodium intake were significantly lower (P < 0.005) than those of infants whose mothers had required low sodium diet and/or diuretics during their pregnancy.

Aldosterone concentrations in plasma of infants 1-72 hr of age and born to mothers on normal sodium intake were 25.9±11.7 ng/100 ml (mean ±1 SD). These values were significantly lower (P < 0.005) than those of infants born to mothers on restricted sodium intake with or without diuretics (80.3±54.4 ng/100 ml). The concentrations at birth were not significantly different from those observed during the first 3 days of life (P > 0.6).

Browse pages

Click on an image below to see the page. View PDF of the complete article

icon of scanned page 386
page 386
icon of scanned page 387
page 387
icon of scanned page 388
page 388
icon of scanned page 389
page 389
icon of scanned page 390
page 390
icon of scanned page 391
page 391
icon of scanned page 392
page 392
icon of scanned page 393
page 393
icon of scanned page 394
page 394
Version history
  • Version 1 (February 1, 1972): No description

Article tools

  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal

Metrics

  • Article usage
  • Citations to this article

Go to

  • Top
  • Abstract
  • Version history
Advertisement
Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts