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Research Article Free access | 10.1172/JCI106824
Harriet Lane Service of the Children's Medical and Surgical Center, The Johns Hopkins Hospital and University, Baltimore, Maryland 21205
Department of Pediatrics, the University of Maryland 21201
Department of Obstetrics and Gynecology, the University of Maryland 21201
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Harriet Lane Service of the Children's Medical and Surgical Center, The Johns Hopkins Hospital and University, Baltimore, Maryland 21205
Department of Pediatrics, the University of Maryland 21201
Department of Obstetrics and Gynecology, the University of Maryland 21201
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Harriet Lane Service of the Children's Medical and Surgical Center, The Johns Hopkins Hospital and University, Baltimore, Maryland 21205
Department of Pediatrics, the University of Maryland 21201
Department of Obstetrics and Gynecology, the University of Maryland 21201
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Harriet Lane Service of the Children's Medical and Surgical Center, The Johns Hopkins Hospital and University, Baltimore, Maryland 21205
Department of Pediatrics, the University of Maryland 21201
Department of Obstetrics and Gynecology, the University of Maryland 21201
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Harriet Lane Service of the Children's Medical and Surgical Center, The Johns Hopkins Hospital and University, Baltimore, Maryland 21205
Department of Pediatrics, the University of Maryland 21201
Department of Obstetrics and Gynecology, the University of Maryland 21201
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Harriet Lane Service of the Children's Medical and Surgical Center, The Johns Hopkins Hospital and University, Baltimore, Maryland 21205
Department of Pediatrics, the University of Maryland 21201
Department of Obstetrics and Gynecology, the University of Maryland 21201
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Published February 1, 1972 - More info
Aldosterone concentrations in plasma of women on normal sodium intake undergoing cesarean section were 3.7±1.4 ng/100 ml (mean±1 SD). These values were significantly lower (P < 0.001) than those observed in mothers on normal sodium diet, delivered by the vaginal route (14.9±7.0 ng/100 ml). A significant elevation (P < 0.001) of the concentrations was found if the mothers had been on sodium restriction and/or diuretics (44.9±24.2 ng/100 ml). In supine position, adult nonpregnant subjects have aldosterone concentrations in plasma of 1.7±1.4 ng/100 ml on normal sodium intake and of 16.7±8.1 ng/100 ml on low sodium diet.
Simultaneous determinations of aldosterone levels in cord blood showed that cord values were significantly higher than those of the corresponding mother (P < 0.01 by paired t test). However, values in cord blood of infants born to mothers on a normal sodium intake were significantly lower (P < 0.005) than those of infants whose mothers had required low sodium diet and/or diuretics during their pregnancy.
Aldosterone concentrations in plasma of infants 1-72 hr of age and born to mothers on normal sodium intake were 25.9±11.7 ng/100 ml (mean ±1 SD). These values were significantly lower (P < 0.005) than those of infants born to mothers on restricted sodium intake with or without diuretics (80.3±54.4 ng/100 ml). The concentrations at birth were not significantly different from those observed during the first 3 days of life (P > 0.6).