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Research Article Free access | 10.1172/JCI106678

Specific removal of in vivo antibody by extracorporeal circulation over an immunoadsorbent in gel

Isaac Schenkein, Jean-Claude Bystryn, and Jonathan W. Uhr

1Irvington House Institute and the Department of Medicine, New York University Medical Center, New York 10016

Find articles by Schenkein, I. in: PubMed | Google Scholar

1Irvington House Institute and the Department of Medicine, New York University Medical Center, New York 10016

Find articles by Bystryn, J. in: PubMed | Google Scholar

1Irvington House Institute and the Department of Medicine, New York University Medical Center, New York 10016

Find articles by Uhr, J. in: PubMed | Google Scholar

Published September 1, 1971 - More info

Published in Volume 50, Issue 9 on September 1, 1971
J Clin Invest. 1971;50(9):1864–1868. https://doi.org/10.1172/JCI106678.
© 1971 The American Society for Clinical Investigation
Published September 1, 1971 - Version history
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Abstract

A method is described for preparation of a solid immunoadsorbent suspended in an agar gel. The immunoadsorbent in gel retains its specificity. Rabbits were injected with antibody or antigen, and an extracorporeal circulation was established through columns or funnels coated with such immunoadsorbents. It was shown that either antibody or antigen can be specifically and rapidly removed, and that no measurable amounts of antigen from the immunoadsorbent were released into the animals.

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