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Research Article Free access | 10.1172/JCI106666

Ligand Kinetics in Hemoglobin Hiroshima

Ronald L. Nagel, Quentin H. Gibson, and Howard B. Hamilton

Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461

Department of Biochemistry and Molecular Biology, Wing Hall, Cornell University, Ithaca, New York 14850

Department of Clinical Laboratories, Atomic Bomb Casualty Commission, * Hiroshima, Japan

*

The Commission is a cooperative research agency of the U.S.A., National Academy of Sciences, National Research Council, and the Japanese National Institutes of Health of the Ministry of Health and Welfare, with funds provided by the U. S. Atomic Energy Commission, the Japanese Institute of Health, and the U.S. Public Health Service.

Received for publication 22 February 1971.

Find articles by Nagel, R. in: PubMed | Google Scholar

Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461

Department of Biochemistry and Molecular Biology, Wing Hall, Cornell University, Ithaca, New York 14850

Department of Clinical Laboratories, Atomic Bomb Casualty Commission, * Hiroshima, Japan

*

The Commission is a cooperative research agency of the U.S.A., National Academy of Sciences, National Research Council, and the Japanese National Institutes of Health of the Ministry of Health and Welfare, with funds provided by the U. S. Atomic Energy Commission, the Japanese Institute of Health, and the U.S. Public Health Service.

Received for publication 22 February 1971.

Find articles by Gibson, Q. in: PubMed | Google Scholar

Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461

Department of Biochemistry and Molecular Biology, Wing Hall, Cornell University, Ithaca, New York 14850

Department of Clinical Laboratories, Atomic Bomb Casualty Commission, * Hiroshima, Japan

*

The Commission is a cooperative research agency of the U.S.A., National Academy of Sciences, National Research Council, and the Japanese National Institutes of Health of the Ministry of Health and Welfare, with funds provided by the U. S. Atomic Energy Commission, the Japanese Institute of Health, and the U.S. Public Health Service.

Received for publication 22 February 1971.

Find articles by Hamilton, H. in: PubMed | Google Scholar

Published August 1, 1971 - More info

Published in Volume 50, Issue 8 on August 1, 1971
J Clin Invest. 1971;50(8):1772–1775. https://doi.org/10.1172/JCI106666.
© 1971 The American Society for Clinical Investigation
Published August 1, 1971 - Version history
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Abstract

Hemoglobin Hiroshima is an electrophoretically fast-moving variant with a fourfold increase in oxygen affinity and a decreased Bohr effect. Based on a decreased rate of dissociation of O2 in the presence of dithionite and an increased rate of binding of CO by the deoxy form, we have concluded that the kinetic basis of the high affinity exhibited by Hb Hiroshima is the concurrence of a faster combination rate and a slower dissociation rate for ligands.

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