Citations to this article

Reversal of Digoxin Toxicity with Specific Antibodies
Donald H. Schmidt, Vincent P. Butler Jr.
Donald H. Schmidt, Vincent P. Butler Jr.
Published August 1, 1971
Citation Information: J Clin Invest. 1971;50(8):1738-1744. https://doi.org/10.1172/JCI106663.
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Reversal of Digoxin Toxicity with Specific Antibodies

Abstract

To determine whether digoxin-specific antibodies can reverse established digoxin toxicity in the dog, digoxin intoxication was produced by the intramuscular administration of digoxin, 0.09 mg/kg, on each of 3 consecutive days. All animals developed toxic arrhythmias (atrioventricular block, ventricular premature contractions and/or ventricular tachycardia). In control animals not receiving antidigoxin antibodies, the arrhythmias persisted throughout a 6 hr study period. Seven of the nine control dogs were dead within 24 hr and one moribund animal was sacrificed at that time; the last animal died within 48 hr.

Authors

Donald H. Schmidt, Vincent P. Butler Jr.

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Citations to this article (80)

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