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Citations to this article

The Glycosaminoglycans of Normal and Arthritic Cartilage
Henry J. Mankin, Louis Lippiello
Henry J. Mankin, Louis Lippiello
Published August 1, 1971
Citation Information: J Clin Invest. 1971;50(8):1712-1719. https://doi.org/10.1172/JCI106660.
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The Glycosaminoglycans of Normal and Arthritic Cartilage

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Abstract

The cartilages from the hip joints of 13 normal and 15 osteoarthritic humans were analyzed for glycosaminoglycan content and distribution. The GAGs were separated by elution with CPC on a short cellulose column by the technique of Svejcar and Robertson after digestion of the tissue with pronase and papain. The eluates were identified by a variety of methods including determination of molar ratios, N-acetyl-hexosamine determinations after hyaluronidase treatment and thin-layer chromatography of unhydrolyzed and hydrolyzed GAGs.

Authors

Henry J. Mankin, Louis Lippiello

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The Glycoconjugates 1977
Chemical composition and swelling of normal and osteoarthrotic femoral head cartilage. I. Chemical composition
M Venn, A Maroudas
Annals of the rheumatic diseases 1977
Biochemical changes in progressive osteoarthrosis
MB Sweet, EJ Thonar, AR Immelman, L Solomon
Annals of the rheumatic diseases 1977
Heberden Oration, 1976. Molecular approach to the understanding of osteoarthrosis
H Muir
Annals of the rheumatic diseases 1977
Effect of intra-articular corticosteroid injections on primate cartilage.
Gibson T, Burry HC, Poswillo D, Glass J
Annals of the rheumatic diseases 1977
Topographical distribution of sulphated glycosaminoglycans in human temporomandibular joint disks. A histochemical study of an autopsy material
S Kopp
Journal of Oral Pathology and Medicine 1976
Organization of ground substance proteoglycans in normal and osteoarthritic knee cartilage
KD Brandt, M Palmoski
Arthritis & Rheumatism 1976
Aggregation of cartilage proteoglycans. Ii. Evidence for the presence of a hyaluronate-binding region on proteoglycans from osteoarthritic cartilage
KD Brandt, MJ Palmoski, E Perricone
Arthritis & Rheumatism 1976
Hyaluronate-binding by proteoglycans. comparison of mildly and severely osteoarthritic regions of human femoral cartilage
M Palmoski, K Brandt
Clinica Chimica Acta 1976
Immunobiology of cartilage
JH Herman, BA Carpenter
Seminars in Arthritis and Rheumatism 1975
Content and Composition of Glycosaminoglycans in Human Knee Joint Cartilage: Variation with Site and Age in Adults
A Bjelle
Connective Tissue Research 1975
Calf articular cartilage in organ culture in a chemically defined medium
RK Lemperg, A Bergenholtz, TW Smith
In Vitro 1975
Hypoxia in fibroblast cultures
PD Kittlick, G Neupert
Experimentelle Pathologie 1975
Calf articular cartilage in organ culture in a chemically defined medium: 2. Concentrations of glycosaminoglycans and [35S]-sulfate incorporation at different oxygen tensions
RK Lemperg, A Bergenholtz, TW Smith
In Vitro 1975
Sulfate Metabolism in Human Chondrocyte Cultures
ER Schwartz, PR Kirkpatrick, RC Thompson
Journal of Clinical Investigation 1974
Glycosaminoglycans of human dentine
IL Jones, AG Leaver
Calcified Tissue Research 1974
Variations in Content and Composition of Glycosaminoglycans Within the Articular Cartilage of the Lower Femoral Epiphysis of An Adult: A Pilot Study
AO Bjelle
Scandinavian Journal of Rheumatology 1974
The glycosaminoglycans of bovine articular cartilage
R Lemperg, SE Larsson, SO Hjertquist
Calcified Tissue Research 1974
Aryl sulfatase activities in normal and pathologic human articular cartilage
ER Schwartz, RC Ogle, RC Thompson
Arthritis & Rheumatism 1974
Enhanced extractability of articular cartilage protoglycans in osteoarthrosis
KD Brandt
Biochemical Journal 1974
The Reaction of Articular Cartilage to Injury and Osteoarthritis
HJ Mankin
New England Journal of Medicine 1974
The glycosaminoglycans of bovine articular cartilage: I. Concentration and distribution in different layers in relation to age
R Lemperg, SE Larsson, SO Hjertquist
Calcified Tissue Research 1974
Biochemistry of articular cartilage. Nature of proteoglycans and collagen of articular cartilage and their role in ageing and in osteoarthrosis
CA McDevitt
Annals of the rheumatic diseases 1973
Distribution of acidic glycosaminoglycans in rabbit growth plate cartilage
RB Greer, S Skinner, A Zarins, HJ Mankin
Calcified Tissue Research 1972
Glycosaminoglycan contents of normal and degenerative articular cartilage from dogs
G Lust, W Pronsky
Clinica Chimica Acta 1972
Protides of the Biological Fluids
PA Small, RH Waldman
Protides of the Biological Fluids 1969

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