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Association of autoantibodies to different nuclear antigens with clinical patterns of rheumatic disease and responsiveness to therapy
Gordon C. Sharp, … , A. D. Kaiser, Halsted R. Holman
Gordon C. Sharp, … , A. D. Kaiser, Halsted R. Holman
Published February 1, 1971
Citation Information: J Clin Invest. 1971;50(2):350-359. https://doi.org/10.1172/JCI106502.
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Research Article

Association of autoantibodies to different nuclear antigens with clinical patterns of rheumatic disease and responsiveness to therapy

Abstract

Using a hemagglutination test which can detect antibodies to (a) native and denatured deoxyribonucleic acid (DNA) and (b) an extractable nuclear antigen (ENA), a comparative study of patterns of autoantibody formation has been done in systemic lupus erythematosus (SLE) and related rheumatic diseases. Antibody to native DNA was present in the serum in 96% of patients with active SLE and disappeared during remissions. Antibody to ENA was found in 86% of those patients with SLE nephritis who responded to treatment but in only 8% of those who did not. The highest titers of antibody to ENA were found in patients having a mixed connective tissue disease syndrome with features of SLE, scleroderma, and myositis. The latter syndrome was notable for the absence of renal disease and for a striking responsiveness to corticosteroid therapy. Hemagglutination testing of 277 sera from normal persons and patients with a wide variety of acute diseases other than SLE revealed the presence of antibody to native DNA in only 1.4% and antibody to ENA in only 0.4%.

Authors

Gordon C. Sharp, William S. Irvin, Robert L. LaRoque, Carmen Velez, Virginia Daly, A. D. Kaiser, Halsted R. Holman

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