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Research Article Free access | 10.1172/JCI106498

Studies of a hypomorphic variant of human C3

Chester A. Alper and Fred S. Rosen

Blood Grouping Laboratory and the Department of Medicine, Children's Hospital Medical Center, Harvard Medical School, Boston, Massachusetts 02115

Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115

Find articles by Alper, C. in: JCI | PubMed | Google Scholar

Blood Grouping Laboratory and the Department of Medicine, Children's Hospital Medical Center, Harvard Medical School, Boston, Massachusetts 02115

Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115

Find articles by Rosen, F. in: JCI | PubMed | Google Scholar

Published February 1, 1971 - More info

Published in Volume 50, Issue 2 on February 1, 1971
J Clin Invest. 1971;50(2):324–326. https://doi.org/10.1172/JCI106498.
© 1971 The American Society for Clinical Investigation
Published February 1, 1971 - Version history
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Abstract

A hypomorphic electrophoretic variant of C3 with the mobility of C3 F was found in the serum of a healthy man, his mother, and one of his two sons. Serum C3 concentrations were normal in these subjects as were hemolytic complement levels. Metabolic studies with radiolabeled purified C3 FF and C3 SS in the propositus suggested, but did not prove, that the variant C3 F gene was hyposynthetic. The designation C3 f was therefore proposed for this allele.

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