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Research Article Free access | 10.1172/JCI106497

Action of neomycin on the intraluminal phase of lipid absorption

Gilbert R. Thompson, James Barrowman, Louis Gutierrez, and R. Hermon Dowling

Department of Medicine, Royal Postgraduate Medical School, London, England

Department of Surgery, Royal Postgraduate Medical School, London, England

Department of Physiology, The London Hospital Medical College, London, England

Find articles by Thompson, G. in: PubMed | Google Scholar

Department of Medicine, Royal Postgraduate Medical School, London, England

Department of Surgery, Royal Postgraduate Medical School, London, England

Department of Physiology, The London Hospital Medical College, London, England

Find articles by Barrowman, J. in: PubMed | Google Scholar

Department of Medicine, Royal Postgraduate Medical School, London, England

Department of Surgery, Royal Postgraduate Medical School, London, England

Department of Physiology, The London Hospital Medical College, London, England

Find articles by Gutierrez, L. in: PubMed | Google Scholar

Department of Medicine, Royal Postgraduate Medical School, London, England

Department of Surgery, Royal Postgraduate Medical School, London, England

Department of Physiology, The London Hospital Medical College, London, England

Find articles by Dowling, R. in: PubMed | Google Scholar

Published February 1, 1971 - More info

Published in Volume 50, Issue 2 on February 1, 1971
J Clin Invest. 1971;50(2):319–323. https://doi.org/10.1172/JCI106497.
© 1971 The American Society for Clinical Investigation
Published February 1, 1971 - Version history
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Abstract

Administration of a single 1 g dose of neomycin sulfate to five healthy subjects simultaneously with a test meal caused a marked increase in the proportion of fatty acid and bile acid in the ultracentrifuged deposit of aspirated intestinal contents. Labeled cholesterol was precipitated in a similar manner in two hypercholesterolemic patients. Neomycin had no effect on the pancreatic lipase concentration or on the pH of intestinal contents. These results confirm that the ability of neomycin to precipitate micellar lipids is due to interaction between the polybasic neomycin molecule and ionized fatty acids and bile acids. This mechanism provides an explanation for both the steatorrhea and hypocholesterolemia induced by this compound.

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