Depression of proximal tubular sodium reabsorption in the dog in response to renal beta adrenergic stimulation by isoproterenol

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Abstract

Water diuresis was produced in anesthetized hypophysectomized, cortisone-treated dogs by infusion of 2.5% dextrose. Alpha adrenergic blockade of the left kidney produced by infusion of phenoxybenzamine in the left renal artery was associated with a significantly (P < 0.05) greater rate of urine flow (V) and free water excretion (CH2O) in the left kidney than in the right despite similar glomerular filtration rates (GFR) (17 ± 1.3 ml/min, left; 18 ±0.9 ml/min, right). Sodium excretion (UNaV) was similar in the two kidneys (3 and 5 μEq/min).

Authors

John R. Gill Jr., Alfred G. T. Casper