Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
Top
  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal
  • Top
  • Abstract
  • Version history
  • Article usage
  • Citations to this article (147)

Advertisement

Research Article Free access | 10.1172/JCI106442

Effects of glucagon on adenosine 3′,5′-monophosphate and guanosine 3′,5′-monophosphate in human plasma and urine

Arthur E. Broadus, Neil I. Kaminsky, Robert C. Northcutt, Joel G. Hardman, Earl W. Sutherland, and Grant W. Liddle

Department of Physiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37203

Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37203

Find articles by Broadus, A. in: PubMed | Google Scholar

Department of Physiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37203

Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37203

Find articles by Kaminsky, N. in: PubMed | Google Scholar

Department of Physiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37203

Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37203

Find articles by Northcutt, R. in: PubMed | Google Scholar

Department of Physiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37203

Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37203

Find articles by Hardman, J. in: PubMed | Google Scholar

Department of Physiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37203

Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37203

Find articles by Sutherland, E. in: PubMed | Google Scholar

Department of Physiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37203

Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37203

Find articles by Liddle, G. in: PubMed | Google Scholar

Published December 1, 1970 - More info

Published in Volume 49, Issue 12 on December 1, 1970
J Clin Invest. 1970;49(12):2237–2245. https://doi.org/10.1172/JCI106442.
© 1970 The American Society for Clinical Investigation
Published December 1, 1970 - Version history
View PDF
Abstract

Glucagon, infused intravenously into fasting, well-hydrated, normal men in doses of 25-200 ng/kg per min, induced up to 30-fold increases in both plasma and urinary cyclic AMP. Cyclic GMP levels were unaffected by glucagon. Simultaneous cyclic AMP and inulin clearance studies demonstrated that the glucagon-induced increase in urinary cyclic AMP was entirely due to glomerular filtration of the elevated plasma levels of the nucleotide.

The cyclic AMP response to glucagon was not mediated by parathyroid hormone or epinephrine, and trypsintreated glucagon was completely inactive.

The perfused rat liver released cyclic AMP into the perfusate in response to glucagon, indicating that the liver is a possible source of the cyclic AMP entering the extracellular fluids in response to glucagon in vivo.

Images.

Browse pages

Click on an image below to see the page. View PDF of the complete article

icon of scanned page 2237
page 2237
icon of scanned page 2238
page 2238
icon of scanned page 2239
page 2239
icon of scanned page 2240
page 2240
icon of scanned page 2241
page 2241
icon of scanned page 2242
page 2242
icon of scanned page 2243
page 2243
icon of scanned page 2244
page 2244
icon of scanned page 2245
page 2245
Version history
  • Version 1 (December 1, 1970): No description

Article tools

  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal

Metrics

  • Article usage
  • Citations to this article (147)

Go to

  • Top
  • Abstract
  • Version history
Advertisement
Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts