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Article has an altmetric score of 10

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Research Article Free access | 10.1172/JCI106358

The influence of the site of infection on the immune response to group A streptococci

Edward L. Kaplan, Bascom F. Anthony, S. Stephen Chapman, Elia M. Ayoub, and Lewis W. Wannamaker

Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota 55455

Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455

Find articles by Kaplan, E. in: PubMed | Google Scholar

Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota 55455

Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455

Find articles by Anthony, B. in: PubMed | Google Scholar

Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota 55455

Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455

Find articles by Chapman, S. in: PubMed | Google Scholar

Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota 55455

Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455

Find articles by Ayoub, E. in: PubMed | Google Scholar

Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota 55455

Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455

Find articles by Wannamaker, L. in: PubMed | Google Scholar

Published July 1, 1970 - More info

Published in Volume 49, Issue 7 on July 1, 1970
J Clin Invest. 1970;49(7):1405–1414. https://doi.org/10.1172/JCI106358.
© 1970 The American Society for Clinical Investigation
Published July 1, 1970 - Version history
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Abstract

The immune response after streptococcal infection of the skin and of the upper respiratory tract (URT) was studied prospectively in a group of normal children, ages 3-6 yr. The children were examined and cultures for group A streptococci were obtained weekly from the throat, nose, and skin lesions (when present). Paired sera were collected at the beginning and end of the study, and the changes in antibody titers were measured for three different streptococcal antigens: streptolysin O, deoxyribonuclease B (DNAse B), and nicotinamide adenine dinucleotidase (NADase).

The findings suggest that in contrast to infection of the URT antibody response to streptolysin O is relatively feeble after streptococcal infection which is limited to the skin. The response to NADase is also poor after cutaneous infection. Antibody responses to DNAse B are generally good regardless of the site of the infection. These and other studies indicate that anti-DNAse B is the antibody of choice in studying streptococcal infection of the skin and its complications.

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Referenced in 1 policy sources
Posted by 2 X users
Referenced in 1 patents
Referenced in 1 clinical guideline sources
35 readers on Mendeley
See more details